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Database: UniProt
Entry: CODY_STRZJ
LinkDB: CODY_STRZJ
Original site: CODY_STRZJ 
ID   CODY_STRZJ              Reviewed;         262 AA.
AC   C1CFG6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=Global transcriptional regulator CodY {ECO:0000255|HAMAP-Rule:MF_00621};
GN   Name=codY {ECO:0000255|HAMAP-Rule:MF_00621}; OrderedLocusNames=SPJ_1490;
OS   Streptococcus pneumoniae (strain JJA).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=488222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JJA;
RX   PubMed=21034474; DOI=10.1186/gb-2010-11-10-r107;
RA   Donati C., Hiller N.L., Tettelin H., Muzzi A., Croucher N.J.,
RA   Angiuoli S.V., Oggioni M., Dunning Hotopp J.C., Hu F.Z., Riley D.R.,
RA   Covacci A., Mitchell T.J., Bentley S.D., Kilian M., Ehrlich G.D.,
RA   Rappuoli R., Moxon E.R., Masignani V.;
RT   "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and
RT   closely related species.";
RL   Genome Biol. 11:R107.1-R107.19(2010).
CC   -!- FUNCTION: DNA-binding global transcriptional regulator which is
CC       involved in the adaptive response to starvation and acts by directly or
CC       indirectly controlling the expression of numerous genes in response to
CC       nutrient availability. During rapid exponential growth, CodY is highly
CC       active and represses genes whose products allow adaptation to nutrient
CC       depletion. {ECO:0000255|HAMAP-Rule:MF_00621}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
CC   -!- SIMILARITY: Belongs to the CodY family. {ECO:0000255|HAMAP-
CC       Rule:MF_00621}.
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DR   EMBL; CP000919; ACO18042.1; -; Genomic_DNA.
DR   RefSeq; WP_000940733.1; NC_012466.1.
DR   AlphaFoldDB; C1CFG6; -.
DR   SMR; C1CFG6; -.
DR   GeneID; 66806674; -.
DR   KEGG; sjj:SPJ_1490; -.
DR   HOGENOM; CLU_089581_0_0_9; -.
DR   Proteomes; UP000002206; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_00621; HTH_type_CodY; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR014154; CodY.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR013198; GTP_trans_reg_CodY_C.
DR   InterPro; IPR010312; Transc_reg_CodY_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   NCBIfam; TIGR02787; codY_Gpos; 1.
DR   PANTHER; PTHR40062:SF1; GLOBAL TRANSCRIPTIONAL REGULATOR CODY; 1.
DR   PANTHER; PTHR40062; GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY; 1.
DR   Pfam; PF06018; CodY; 1.
DR   Pfam; PF08222; HTH_CodY; 1.
DR   PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..262
FT                   /note="Global transcriptional regulator CodY"
FT                   /id="PRO_1000147212"
FT   DNA_BIND        207..226
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
FT   REGION          1..159
FT                   /note="GAF domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
SQ   SEQUENCE   262 AA;  29756 MW;  F11B71CB1D35345D CRC64;
     MAHLLEKTRK ITSILKRSEE QLQDELPYNA ITRQLADIIH CNACIINSKG RLLGYFMRYK
     TNTDRVEQFF QTKIFPDDYV QGANMIYETE ANLPVEHDMS IFPVESRDDF PDGLTTIAPI
     HVSGIRLGSL IIWRNDKKFE DEDLVLVEIA STVVGIQLLN FQREEDEKNI RRRTAVTMAV
     NTLSYSELRA VSAILGELNG NEGKLTASVI ADRIGITRSV IVNALRKLES AGIIESRSLG
     MKGTYLKVLI SDIFEEVKKR DY
//
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