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Database: UniProt
Entry: CSM3_COCIM
LinkDB: CSM3_COCIM
Original site: CSM3_COCIM 
ID   CSM3_COCIM              Reviewed;         337 AA.
AC   Q1DME8; J3K6B5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=Chromosome segregation in meiosis protein 3;
GN   Name=CSM3; ORFNames=CIMG_08515;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Forms a fork protection complex (FPC) with TOF1 and which is
CC       required for chromosome segregation during meiosis and DNA damage
CC       repair. FPC coordinates leading and lagging strand synthesis and moves
CC       with the replication fork. FPC stabilizes replication forks in a
CC       configuration that is recognized by replication checkpoint sensors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC       TOF1 and CSM3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000305}.
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DR   EMBL; GG704913; EAS29769.3; -; Genomic_DNA.
DR   RefSeq; XP_001241352.2; XM_001241351.2.
DR   AlphaFoldDB; Q1DME8; -.
DR   SMR; Q1DME8; -.
DR   STRING; 246410.Q1DME8; -.
DR   GeneID; 4560346; -.
DR   KEGG; cim:CIMG_08515; -.
DR   VEuPathDB; FungiDB:CIMG_08515; -.
DR   InParanoid; Q1DME8; -.
DR   OMA; MRKEWIN; -.
DR   OrthoDB; 1388129at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0000076; P:DNA replication checkpoint signaling; IEA:InterPro.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0008156; P:negative regulation of DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0031297; P:replication fork processing; IEA:InterPro.
DR   InterPro; IPR012923; Csm3.
DR   InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR   PANTHER; PTHR13220; TIMELESS INTERACTING-RELATED; 1.
DR   PANTHER; PTHR13220:SF11; TIMELESS-INTERACTING PROTEIN; 1.
DR   Pfam; PF07962; Swi3; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..337
FT                   /note="Chromosome segregation in meiosis protein 3"
FT                   /id="PRO_0000301717"
FT   REGION          21..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   337 AA;  37636 MW;  F9FD4E17DC6BF855 CRC64;
     MAEDTAFDDL FNYDAGIEEL LRDPEEEKND RRASGTGTGS TENKNDDLIG LEEIKITRKR
     APPVKLDENR LLSQAGIPKL RRSAKTKLKF KGKRHEFSDV ARLLNFYQLW LDDLYPRAKF
     ADGLSIIEKL GHTKRMQVMR KEWIDEGKPG RNLYDSNVTY LDPNSDNRGD KDTADPTIPS
     IFQRTLEQSA PAMEAHRNDQ AESTHSPKRL SDSEIPIFGG GKAISLRNNA DDDDDLFVPG
     NEGMDIDPPV QASQVPEEDD LDTFLAEQES TMQNTAHGLG ILKPNAPPAD EEDDLDALLA
     EAENTPARAP KTGHLEANRP AADDFDDELH ILNEFGL
//
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