ID CUBN_DROME Reviewed; 3750 AA.
AC Q9W332; Q8T4G4;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 3.
DT 27-MAR-2024, entry version 166.
DE RecName: Full=Cubilin homolog {ECO:0000312|FlyBase:FBgn0052702};
DE Flags: Precursor;
GN Name=Cubn {ECO:0000312|FlyBase:FBgn0052702};
GN ORFNames=CG32702 {ECO:0000312|FlyBase:FBgn0052702};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL89938.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2680-3750.
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL89938.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAL89938.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=23264686; DOI=10.1681/asn.2012080795;
RA Zhang F., Zhao Y., Chao Y., Muir K., Han Z.;
RT "Cubilin and amnionless mediate protein reabsorption in Drosophila
RT nephrocytes.";
RL J. Am. Soc. Nephrol. 24:209-216(2013).
CC -!- FUNCTION: Required in the nephrocyte for normal uptake of proteins and
CC elimination of toxins, and for maintenance of endocytic trafficking
CC structures. May function together with Amnionless.
CC {ECO:0000269|PubMed:23264686}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:23264686};
CC Peripheral membrane protein {ECO:0000305|PubMed:23264686}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in nephrocytes.
CC {ECO:0000269|PubMed:23264686}.
CC -!- DEVELOPMENTAL STAGE: Detected only in garland nephrocytes at the
CC embryonic stage. Highly expressed in both garland and pericardial
CC nephrocytes at the larval stage. {ECO:0000269|PubMed:23264686}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL89938.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAL89938.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE014298; AAF46505.3; -; Genomic_DNA.
DR EMBL; AY084200; AAL89938.1; ALT_SEQ; mRNA.
DR RefSeq; NP_727348.2; NM_167193.2.
DR SMR; Q9W332; -.
DR IntAct; Q9W332; 4.
DR STRING; 7227.FBpp0271945; -.
DR GlyCosmos; Q9W332; 41 sites, No reported glycans.
DR GlyGen; Q9W332; 41 sites.
DR PaxDb; 7227-FBpp0271945; -.
DR EnsemblMetazoa; FBtr0273437; FBpp0271945; FBgn0052702.
DR GeneID; 326235; -.
DR KEGG; dme:Dmel_CG32702; -.
DR UCSC; CG32702-RB; d. melanogaster.
DR AGR; FB:FBgn0052702; -.
DR CTD; 8029; -.
DR FlyBase; FBgn0052702; Cubn.
DR VEuPathDB; VectorBase:FBgn0052702; -.
DR eggNOG; KOG4292; Eukaryota.
DR GeneTree; ENSGT00940000167878; -.
DR HOGENOM; CLU_000172_1_0_1; -.
DR InParanoid; Q9W332; -.
DR OMA; RGFTVRW; -.
DR OrthoDB; 2917265at2759; -.
DR PhylomeDB; Q9W332; -.
DR SignaLink; Q9W332; -.
DR BioGRID-ORCS; 326235; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 326235; -.
DR PRO; PR:Q9W332; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0052702; Expressed in oviduct (Drosophila) and 21 other cell types or tissues.
DR ExpressionAtlas; Q9W332; baseline and differential.
DR Genevisible; Q9W332; DM.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IPI:FlyBase.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038024; F:cargo receptor activity; IDA:FlyBase.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IMP:FlyBase.
DR GO; GO:0097206; P:nephrocyte filtration; IMP:FlyBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0097017; P:renal protein absorption; IMP:FlyBase.
DR CDD; cd00041; CUB; 21.
DR CDD; cd22201; cubilin_NTD; 1.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 26.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 19.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF12661; hEGF; 1.
DR SMART; SM00042; CUB; 23.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 26.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01180; CUB; 23.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 2: Evidence at transcript level;
KW Calcium; Cell membrane; Disulfide bond; EGF-like domain; Glycoprotein;
KW Membrane; Metal-binding; Protein transport; Reference proteome; Repeat;
KW Signal; Transport.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..3750
FT /note="Cubilin homolog"
FT /id="PRO_5004336462"
FT DOMAIN 154..190
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 192..233
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 282..308
FT /note="EGF-like 3; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 324..352
FT /note="EGF-like 4; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 426..463
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 465..503
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 509..623
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 627..738
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 744..852
FT /note="CUB 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 853..971
FT /note="CUB 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 978..1095
FT /note="CUB 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1100..1212
FT /note="CUB 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1216..1331
FT /note="CUB 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1332..1434
FT /note="CUB 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1439..1550
FT /note="CUB 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1554..1670
FT /note="CUB 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1671..1788
FT /note="CUB 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1792..1902
FT /note="CUB 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1903..2001
FT /note="CUB 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2019..2139
FT /note="CUB 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2140..2256
FT /note="CUB 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2262..2383
FT /note="CUB 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2385..2512
FT /note="CUB 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2516..2646
FT /note="CUB 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2761..2895
FT /note="CUB 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2898..3010
FT /note="CUB 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 3011..3128
FT /note="CUB 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 3130..3246
FT /note="CUB 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 3249..3364
FT /note="CUB 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 3368..3512
FT /note="CUB 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 3522..3615
FT /note="CUB 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 3623..3736
FT /note="CUB 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT BINDING 1026
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:O60494"
FT BINDING 1034
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:O60494"
FT BINDING 1080
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:O60494"
FT BINDING 1148
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:O60494"
FT BINDING 1156
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:O60494"
FT BINDING 1197
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:O60494"
FT BINDING 1264
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000250|UniProtKB:O60494"
FT BINDING 1272
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000250|UniProtKB:O60494"
FT BINDING 1316
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000250|UniProtKB:O60494"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 123
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 424
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 448
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 542
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 548
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 609
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 871
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1119
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1335
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1359
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1413
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1424
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1491
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1694
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1908
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2009
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2092
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2231
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2377
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2442
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2655
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2671
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2682
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2772
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2885
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2889
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2960
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2965
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2982
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3040
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3074
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3427
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3543
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3572
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3645
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 158..169
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 163..178
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 180..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 196..212
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 206..221
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 223..232
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 430..441
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 435..451
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 453..462
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 469..480
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 474..491
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 493..502
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 509..535
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 562..584
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 627..654
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 681..701
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 744..770
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 853..879
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 913..933
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 978..1004
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1031..1058
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1100..1126
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1153..1175
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1216..1242
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1269..1292
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1332..1360
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1439..1465
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1492..1513
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1554..1580
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1607..1631
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1671..1697
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1733..1755
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1792..1818
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1845..1866
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2019..2048
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2077..2100
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2140..2167
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2324..2346
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2385..2416
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2445..2474
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2516..2542
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2761..2790
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2837..2859
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2898..2921
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2949..2973
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 3011..3039
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 3070..3092
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 3130..3157
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 3184..3207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 3249..3278
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 3305..3327
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 3368..3402
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 3430..3475
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 3560..3579
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 3623..3649
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 3676..3699
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 3750 AA; 418179 MW; 5AB91F68084C5B6C CRC64;
MEGAARSRLL LCWTLLAIIT DTWPIAEGFV NSPKIISKDG NLIFESGANR NISFRLSGNS
RLTINEELDV MELLLATSGS KKRSGGKDDD FVDARELADQ LADFNRRAFG ANGLSAMLRV
QQNRTRGSMA LLRRFQTRLR ALENRVDRMK TDLEANSCAS GPCENGGTCY NTYTGFRCQC
RSAFEGTKCE MDVNECALYE GTDLGCQNGG QCQNHFGTYS CLCQPGWHGM HCTQRKADCS
QSSAWELCGH GSCVPSADDA GYRCICEPGW KTNGLTPICG EDVDECSDSA AHKPCSTSCI
NLPGSFTCAP CPAGLTGNGV SCRDLDECQT NNGGCSLSPK VDCINTYGSY HCGECPVGWT
GDGRKCERSP QDIDIPAGQT PRTCPAGNNP CYPTASCFLI SGTTSCRCPM GMVGTGYGPN
GCVNGTTTNC KENPCLNGGI CLFAGPSNYT CLCPIGFRPP ICEPQPSPCD QHPCKNGGRC
RPTTSGDLFV CQCLPGYRGR LCETRFSSCN GMLSAQSGRL RYPPEGTGYE HNAQCAWVIR
TNESLVVNVT FNSFDVEDST ECRFDWLQIN DGRSAAAQII GRYCGNHLPH GGNIVSSGNQ
LYLWFRSDNS TAKEGFDLTW NSMEPQCGGR LNFETHGTLA SPGSPGNYPK NRDCRWQLVA
PTTKRIKLTF FSLQLEQHAN CNFDYVLIKD SISGRELAKY CTTGAPAPLL LPTHLAEIHF
HSDAEGSDTG FQLHYSVEER VPGCGGVYTA KEGTISESST ANTEPGGVSC EYEIHLAVGE
QVVIQFARLE LDPLDCLEVL DITDEGGSIL QEKICGSDAS RLNPPTFTSE FNRLKIKFYA
RAGSFQLNYR MACDYKLNNE QGTITSPGYP NLTRSDRICT YTISTATNTV ISLKRIDFQL
TNGESDDDDN DECLTTNLRI NDGLNRKILG PYCGKNQPEE NFVSETNYLQ LHLSTDVDSM
GRGFKFEYRA LATGNDKCGG VHTRSGDHIR LPVHDDSYAG EATCYWVIMA PANKAIRLHW
NSFSLENAVD CIYDYLEIYD SLGAQVNDER SKPLAKYCGN SVPEDLLSHS RQLVLKFVSD
YSESDGGFDL TYTFEDRAKC GGHIHASSGE LTSPEYPANY SAGLDCDWHL TGTIDHLLEI
QVENFELEQS PNCSADYLEV RNGGGTDSPL IGRFCGRDIP ARIPGFSHEM RLILHTDSAI
NGRGFRLRWR IFAFGCGGSL RSNMGAISSP RYPNSYPNMA HCEWRISLHP GSGISLLIED
LELEGLSNCY YDSVKIYTGI KLPNQSPCKV LCKDDDLHNP LIQLENNKGT IVFDSDASNT
FRGFRISYKA NCIRNLTATT GTIESLNYME PFWETIPINC SWTIRAPKGN RVLVEVSHLA
RHEQHVPTAT MPGGLYIVDG RNVQEIVTPQ AMNISGEVLT VVHNASNVNF QLDYRIDGCM
EELRGTFGFF QSPNYPKMYP NNLECYWLIT VEQDSAIELT INNIDLEDSP NCTKDALTVS
NHKNSVEVHE RHCGSTTKLV ITSSGHRLHV RFISDNSHNG LGFEATYRTV KATCGGKLTA
RNGVIESPNY PLNYPAHSRC EWQVEVSQHH QIVFEMADLN LESGYDCNWD YLEAYDLTED
DTEGERLFKV CGDETEDDKL LSSSSNMAVV RFISDDSVSK KGFRLHFHES CGQTIIVDET
MFDYIQMSRQ AARNESCLWV FQAVEPNKRI IFTPTHVKLR EDANQQYPTE GDCLNVGVKI
YEGTEPQGTP RLKFCRSHPP ALISNGQALT VSVPLQLVEE FQGHYMTMDT SCGSIYNALS
GKFTSPYYPA SYPPNIECLW LLEASMGNSL SLTLESMDLE KSESCNRDYL EVREESESGQ
LIGVYCGNEV PGVIHSRGAI WMKFKSDDDN VGEGFMASYN YEHHNELNGT EGTIESPHFP
SKFQDPVPYS WRITVDKEYV VAISLLYLRD LDQPHLNFYD GYSDIGARIE VTDPDETIIS
STNVVYFTSN RGPFKLNWNR LSKEALRSNR TAEERTRQCG NQLITIDRSV IGFHSPGYPN
GYEQDLNCFW TLVPSNPAMH AVLTLSQIDL EIFSEDCIAD YVKIFSGSDL QNWSELRTLC
SLPTESSDRV FHGRPYLRVE FVTDPSVNKT GFNGIVRTAC GSEITASKGL VNITEILKVL
PRPNHDCVWT IKVRQGRRIK IDFPDFQLQN NMASGSSDCR NYLLLRNGND EDSPFLGRGK
YCEDVVHEVL NTSSNKAYIK FHFASPPRFL VSFRFEELRY TDSGRIRLSA SGDEQFISSP
YYPHLPHPHS ECIWIVEAPP EHRIMLHFQG AFDMLDATGE PEECQREFVL INDGSTELRP
EIGRYCGNRK PDTIYSTGNQ MRIRYFTDVS EPHMGFNASL SVARCGGSFH SPEGVIASPS
RDLLLIHEEG KQLQECVYTI ELEKGSTIDL TSEYLQIPTL RNGSCSQRNH LMLEEMDAFG
LDGEEKIVDT LMLCGMEAKH LISETNKIVF RYRFLDGIPA ENQGFRLKYT SLGSRCGETI
YASVGVLQTP GYPLGVPHPM HCKWQVQVPK GRRVRLEILD FNTGTNMDLR GRLGFRGRLT
VANDFKMQSI LGRYNVDPPA EVLSSDNTMG IDAFLLPIVQ NHGIKLRFSA YGSSSCPGFT
VMMNEVADIQ FQRFNISRPL HCSYKVVPPS NSTLLIRVKE YNTTSVMMWN THMCALLSPL
KFNRLEQEEE LMERILCDYQ SPAPGKPLPS IRLPFPIQLV VSASARNAMT NLVLSYSTQS
CGGVIILEPG DNMTVHQPSG MVSAAGAIDC AWAIGPYTDA SGEDEVLVPQ DIQLEVSVYN
VNLPAPSPSA QSPEAPCLHH YLKVYNGPDQ NSPSLGLFCN QATAVNMVVE RGLFLEYHSD
SFSANATFNV SIKYGSGCGG KLVYPYRAID FAEQYKNNVE CIWEVEATMG YHIGLTFQGR
FYIEDSPGCT KDYLLVQQRN ETTGNWTDLQ RICGRVAPEM INTTSPYLRL IFRSDGDVVA
DGFLAKFERN CGGLLYADST EQELASPGFP NGYEKYLQCN WTIVPRSPSM GGVLVSFVNF
DLEQGPISVC LYDNLTVTTK DKGKDPQQTT LCGVKHNHEY RGKEYVNLLL RTDGSYSGRG
FTLLYTSRLC GGIISRTSMV ESPVQHTDNT LPPGSDCYWN LTAPAGYKFN IKFLFIDFEA
NSNCAYDGVE VFSGPIPDER YRWGRFCGRI NEDLPLISIP QERGIIHSFS DDRDPSRGFR
ALVRVMPNCD EKISLNGSSR YVYSKFNNAG GYQNDLDCQI VFRVNPDQQI SVEFSNFHVQ
DTDGCRSDYV ELRDGGGTFA DIIGRFCGQN QPPTLRTTRH TLYMRFVTDN KVTDTGFQVT
INAIPRLCGS SEITLSADGT KEVTINSPAR TPGGNYPNGV SCFWKIKGDS LLRVQFVNFD
LHGPNQNGSC VDDYLKIYNS EDAPLLEQGL GTDLVFNGQT SSKNGFGFAT EHVYCGNVKP
DIYYGRSSEV YLKFRSKGLE QHGGFQLQVA LNSNRERHYD GLQGRVHLSQ SADCNIIIRA
PPNYTLSLYY TELIFGTYDC EMENLEVFDR TNRSLQRVCS FVDMGKSLFS NANELRLQMK
TGSYLTSLDL TYLASPVEKG PGCGGQFYNT EGIFSNPFYP NNVRNNSECQ WIVRVPSNNV
VFLTFEVFNL GSKTTCHTDY LQILEQDATG EEREMRRFCG EDNPKYYKSR RSQVLVRFHK
TVNYDGIGWV IRFAGVYSDH QIPRHLLGGS
//
