ID CUPC_DICDI Reviewed; 769 AA.
AC Q7Z202; Q54HP9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=Calcium up-regulated protein C;
GN Name=cupC; ORFNames=DDB_G0289283;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=14871937; DOI=10.1128/ec.3.1.61-71.2004;
RA Coukell B., Li Y., Moniakis J., Cameron A.;
RT "The Ca2+/calcineurin-regulated cup gene family in Dictyostelium discoideum
RT and its possible involvement in development.";
RL Eukaryot. Cell 3:61-71(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May play an important role in stabilizing and/or regulating
CC the cell membrane during Ca(2+) stress or certain stages of
CC development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed at high levels during aggregation and
CC late development and at low levels during the slug stage.
CC {ECO:0000269|PubMed:14871937}.
CC -!- INDUCTION: Induced by high levels of extracellular Ca(2+).
CC {ECO:0000269|PubMed:14871937}.
CC -!- SIMILARITY: Belongs to the cup family. {ECO:0000305}.
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DR EMBL; AY282569; AAP40291.1; -; Genomic_DNA.
DR EMBL; AAFI02000136; EAL62788.1; -; Genomic_DNA.
DR RefSeq; XP_636312.1; XM_631220.1.
DR AlphaFoldDB; Q7Z202; -.
DR SMR; Q7Z202; -.
DR CAZy; CBM13; Carbohydrate-Binding Module Family 13.
DR PaxDb; 44689-DDB0191377; -.
DR EnsemblProtists; EAL62788; EAL62788; DDB_G0289283.
DR GeneID; 8627073; -.
DR KEGG; ddi:DDB_G0289283; -.
DR dictyBase; DDB_G0289283; cupC.
DR HOGENOM; CLU_020711_0_0_1; -.
DR InParanoid; Q7Z202; -.
DR PhylomeDB; Q7Z202; -.
DR PRO; PR:Q7Z202; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0043157; P:response to cation stress; IDA:dictyBase.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR31599; CALCIUM UP-REGULATED PROTEIN A-RELATED; 1.
DR PANTHER; PTHR31599:SF2; CALCIUM UP-REGULATED PROTEIN A-RELATED; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 2.
DR PROSITE; PS50231; RICIN_B_LECTIN; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Lectin; Membrane; Reference proteome; Repeat.
FT CHAIN 1..769
FT /note="Calcium up-regulated protein C"
FT /id="PRO_0000327951"
FT DOMAIN 25..145
FT /note="Ricin B-type lectin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT DOMAIN 158..296
FT /note="Ricin B-type lectin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 769 AA; 85061 MW; 357E3DDFE2154AF6 CRC64;
MINIEDISKS SNQSEEKQLK STSSKTKYPF AAKSLFKGSN NITPYYLSTS NTFQCVASES
IQTWLLSDDG HIFTSSGNFV LDVSSGGYFV ELVQLNSNSK TQIWTIDTTN NKIQNQGNGK
YLDIDNLNIC VAPLNGNATQ KWTTFRRAPI PTGNWGYFQS KKLDSNNNYW GLSVLNNSTS
YNTSVVMNKV QAKSIGQIWQ MTNDGHILSR LDGNLVLDIG PSINGSKTNY YLNTNVYKAN
DLMQQWGINE NNQIFNQYYP NLCIGFVGEL GVDSTVNCVL AQPTSAGNIN FQWIANPTYS
LNQIVSEVPE PFPAYTSGDL LASYQYLSNI ATNGYTDDIR SLYTSINVSL EIFYVNVTNA
TCPSSIHSTE DFSNVQNQIK NELTYAINVR LVFDNYSDFY SKLFSQGSTN LTNLANLINV
DMSSDQVVNG DYTDAITSVF YAIISEIPIG GSIIANIGES AVEFGELDAE SNDSGPSTYQ
VTLSKLYDHL NENYENEMAN AQSMKNTILQ DWGMMSKTFA LCFLPTNNPS SLNINGLDFQ
KISTIASIAY QTAMIQMLLP TNYQIYFTPA GYYAPVSSDD YSYTDSTGTY IMAEIDNCNS
HPPKALTDKL WNNGVSKQEV FTSSYGWNLA TSVTYYNMVG KYSGMFKLSF PTVKNFTSVP
MQFVMTNGSD RVGTFNVKTH FAGLASTYYY SGALGHHYYD IAVIDINGNK VANFTVDNNL
EALEGSYVSI KTNSLVVQPG YVVGNPTCNQ GSFSQGFAAS ILIPIYKSN
//
