ID   CXB6_CHICK              Reviewed;         263 AA.
AC   O93533;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-APR-2013, entry version 75.
DE   RecName: Full=Gap junction beta-6 protein;
DE   AltName: Full=Connexin-31;
DE            Short=Cx31;
GN   Name=GJB6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   STRAIN=White leghorn; TISSUE=Basilar papilla;
RX   PubMed=9736748; DOI=10.1073/pnas.95.19.11400;
RA   Heller S., Sheane C.A., Javed Z., Hudspeth A.J.;
RT   "Molecular markers for cell types of the inner ear and candidate genes
RT   for hearing disorders.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:11400-11405(1998).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which
CC       materials of low MW diffuse from one cell to a neighboring cell
CC       (By similarity).
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity). Cell junction, gap junction (By similarity).
CC   -!- TISSUE SPECIFICITY: Exclusively expressed in the cochlea of the
CC       inner ear, where it is found in cells of the tegmentum vasculosum,
CC       cuboidal cells, supporting cells and clear cells.
CC   -!- DEVELOPMENTAL STAGE: Specifically expressed at the late
CC       developmental stages in the cochlea.
CC   -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I)
CC       subfamily.
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DR   EMBL; AF072699; AAC64043.1; -; mRNA.
DR   IPI; IPI00575624; -.
DR   RefSeq; NP_990262.1; NM_204931.1.
DR   UniGene; Gga.1951; -.
DR   STRING; 9031.ENSGALP00000027628; -.
DR   PaxDb; O93533; -.
DR   Ensembl; ENSGALT00000027681; ENSGALP00000027628; ENSGALG00000017136.
DR   GeneID; 395771; -.
DR   KEGG; gga:395771; -.
DR   CTD; 10804; -.
DR   eggNOG; NOG39645; -.
DR   GeneTree; ENSGT00700000104145; -.
DR   HOGENOM; HOG000231127; -.
DR   HOVERGEN; HBG009576; -.
DR   InParanoid; O93533; -.
DR   KO; K07625; -.
DR   OMA; MDWSTLQ; -.
DR   OrthoDB; EOG4PK28F; -.
DR   NextBio; 20815839; -.
DR   GO; GO:0005922; C:connexon complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   Pfam; PF10582; Connexin_CCC; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Complete proteome; Gap junction;
KW   Hearing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    263       Gap junction beta-6 protein.
FT                                /FTId=PRO_0000057873.
FT   TOPO_DOM      1     19       Cytoplasmic (Potential).
FT   TRANSMEM     20     40       Helical; (Potential).
FT   TOPO_DOM     41     75       Extracellular (Potential).
FT   TRANSMEM     76     96       Helical; (Potential).
FT   TOPO_DOM     97    137       Cytoplasmic (Potential).
FT   TRANSMEM    138    158       Helical; (Potential).
FT   TOPO_DOM    159    189       Extracellular (Potential).
FT   TRANSMEM    190    210       Helical; (Potential).
FT   TOPO_DOM    211    263       Cytoplasmic (Potential).
SQ   SEQUENCE   263 AA;  30923 MW;  D809506A6DB628BA CRC64;
     MDWGALQTIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA ERVWGDEQDD FICNTLQPGC
     KNVCYDHFFP ISHIRLWALQ LIFVSTPALL VAMHVAYRRH EKKRQFRKGD QKCEYKDIEE
     IRTQRFRIEG TLWWTYTCSI FFRLVFEAVF MYAFYFMYDG FRMPRLMKCS AWPCPNTVDC
     FVSRPTEKTV FTIFMIAVSS ICILLNVAEL CYLLTKFFLR RSRKAGNQKH HPNHENKEET
     KQNEMNELIS DSCQNTVIGF TSS
//