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Database: UniProt
Entry: CXB6_CHICK
LinkDB: CXB6_CHICK
Original site: CXB6_CHICK 
ID   CXB6_CHICK              Reviewed;         263 AA.
AC   O93533;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   01-OCT-2014, entry version 83.
DE   RecName: Full=Gap junction beta-6 protein;
DE   AltName: Full=Connexin-31;
DE            Short=Cx31;
GN   Name=GJB6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Testudines + Archosauria group; Archosauria; Dinosauria; Saurischia;
OC   Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000312|EMBL:AAC64043.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   STRAIN=White leghorn; TISSUE=Basilar papilla;
RX   PubMed=9736748; DOI=10.1073/pnas.95.19.11400;
RA   Heller S., Sheane C.A., Javed Z., Hudspeth A.J.;
RT   "Molecular markers for cell types of the inner ear and candidate genes
RT   for hearing disorders.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:11400-11405(1998).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which
CC       materials of low MW diffuse from one cell to a neighboring cell.
CC       {ECO:0000255|RuleBase:RU000630, ECO:0000305}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC       {ECO:0000255|RuleBase:RU000630, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Cell junction, gap junction
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Exclusively expressed in the cochlea of the
CC       inner ear, where it is found in cells of the tegmentum vasculosum,
CC       cuboidal cells, supporting cells and clear cells.
CC       {ECO:0000269|PubMed:9736748}.
CC   -!- DEVELOPMENTAL STAGE: Specifically expressed at the late
CC       developmental stages in the cochlea. {ECO:0000269|PubMed:9736748}.
CC   -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF072699; AAC64043.1; -; mRNA.
DR   RefSeq; NP_990262.1; NM_204931.1.
DR   UniGene; Gga.1951; -.
DR   STRING; 9031.ENSGALP00000027628; -.
DR   PaxDb; O93533; -.
DR   Ensembl; ENSGALT00000027681; ENSGALP00000027628; ENSGALG00000017136.
DR   GeneID; 395771; -.
DR   KEGG; gga:395771; -.
DR   CTD; 10804; -.
DR   eggNOG; NOG39645; -.
DR   GeneTree; ENSGT00750000117376; -.
DR   HOGENOM; HOG000231127; -.
DR   HOVERGEN; HBG009576; -.
DR   InParanoid; O93533; -.
DR   KO; K07625; -.
DR   OMA; MYVFYIM; -.
DR   OrthoDB; EOG7P2XSS; -.
DR   PhylomeDB; O93533; -.
DR   TreeFam; TF329606; -.
DR   NextBio; 20815839; -.
DR   PRO; PR:O93533; -.
DR   GO; GO:0005922; C:connexon complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005243; F:gap junction channel activity; IEA:Ensembl.
DR   GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   Pfam; PF10582; Connexin_CCC; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Complete proteome; Gap junction;
KW   Hearing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    263       Gap junction beta-6 protein.
FT                                /FTId=PRO_0000057873.
FT   TOPO_DOM      1     19       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     20     40       Helical. {ECO:0000255}.
FT   TOPO_DOM     41     75       Extracellular. {ECO:0000255}.
FT   TRANSMEM     76     96       Helical. {ECO:0000255}.
FT   TOPO_DOM     97    137       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    138    158       Helical. {ECO:0000255}.
FT   TOPO_DOM    159    189       Extracellular. {ECO:0000255}.
FT   TRANSMEM    190    210       Helical. {ECO:0000255}.
FT   TOPO_DOM    211    263       Cytoplasmic. {ECO:0000255}.
SQ   SEQUENCE   263 AA;  30923 MW;  D809506A6DB628BA CRC64;
     MDWGALQTIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA ERVWGDEQDD FICNTLQPGC
     KNVCYDHFFP ISHIRLWALQ LIFVSTPALL VAMHVAYRRH EKKRQFRKGD QKCEYKDIEE
     IRTQRFRIEG TLWWTYTCSI FFRLVFEAVF MYAFYFMYDG FRMPRLMKCS AWPCPNTVDC
     FVSRPTEKTV FTIFMIAVSS ICILLNVAEL CYLLTKFFLR RSRKAGNQKH HPNHENKEET
     KQNEMNELIS DSCQNTVIGF TSS
//
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