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Database: UniProt
Entry: CXE5_ARATH
LinkDB: CXE5_ARATH
Original site: CXE5_ARATH 
ID   CXE5_ARATH              Reviewed;         319 AA.
AC   Q9FX94;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 122.
DE   RecName: Full=Probable carboxylesterase 5;
DE   AltName: Full=AtCXE5;
DE            EC=3.1.1.1;
GN   Name=CXE5; OrderedLocusNames=At1g49660; ORFNames=F14J22.11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT   "Arabidopsis cDNA clones.";
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=14738307; DOI=10.1007/s00239-003-2492-8;
RA   Marshall S.D., Putterill J.J., Plummer K.M., Newcomb R.D.;
RT   "The carboxylesterase gene family from Arabidopsis thaliana.";
RL   J. Mol. Evol. 57:487-500(2003).
CC   -!- FUNCTION: Carboxylesterase acting on esters with varying acyl chain
CC       length. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+);
CC         Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1;
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems, flowers and
CC       siliques. {ECO:0000269|PubMed:14738307}.
CC   -!- SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; AC011807; AAG13052.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE32456.1; -; Genomic_DNA.
DR   EMBL; BT022077; AAY27064.1; -; mRNA.
DR   PIR; C96533; C96533.
DR   RefSeq; NP_175389.1; NM_103854.3.
DR   AlphaFoldDB; Q9FX94; -.
DR   SMR; Q9FX94; -.
DR   STRING; 3702.Q9FX94; -.
DR   ESTHER; arath-F14J22.11; Plant_carboxylesterase.
DR   iPTMnet; Q9FX94; -.
DR   PaxDb; 3702-AT1G49660-1; -.
DR   ProteomicsDB; 220516; -.
DR   EnsemblPlants; AT1G49660.1; AT1G49660.1; AT1G49660.
DR   GeneID; 841390; -.
DR   Gramene; AT1G49660.1; AT1G49660.1; AT1G49660.
DR   KEGG; ath:AT1G49660; -.
DR   Araport; AT1G49660; -.
DR   TAIR; AT1G49660; CXE5.
DR   eggNOG; KOG1515; Eukaryota.
DR   HOGENOM; CLU_012494_22_0_1; -.
DR   InParanoid; Q9FX94; -.
DR   OMA; GEGHEPW; -.
DR   OrthoDB; 5397115at2759; -.
DR   PhylomeDB; Q9FX94; -.
DR   BioCyc; ARA:AT1G49660-MONOMER; -.
DR   PRO; PR:Q9FX94; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9FX94; baseline and differential.
DR   Genevisible; Q9FX94; AT.
DR   GO; GO:0005829; C:cytosol; HDA:TAIR.
DR   GO; GO:0106435; F:carboxylesterase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IDA:TAIR.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013094; AB_hydrolase_3.
DR   PANTHER; PTHR23024; ARYLACETAMIDE DEACETYLASE; 1.
DR   PANTHER; PTHR23024:SF529; CARBOXYLESTERASE 5-RELATED; 1.
DR   Pfam; PF07859; Abhydrolase_3; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Hydrolase; Reference proteome; Serine esterase.
FT   CHAIN           1..319
FT                   /note="Probable carboxylesterase 5"
FT                   /id="PRO_0000402551"
FT   MOTIF           79..81
FT                   /note="Involved in the stabilization of the negatively
FT                   charged intermediate by the formation of the oxyanion hole"
FT                   /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT   ACT_SITE        163
FT                   /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT   ACT_SITE        262
FT                   /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT   ACT_SITE        294
FT                   /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SMN0"
SQ   SEQUENCE   319 AA;  35197 MW;  D4604D56F70A4AF6 CRC64;
     MESEIASEFL PFCRIYKDGR VERLIGTDTI PASLDPTYDV VSKDVIYSPE NNLSVRLFLP
     HKSTKLTAGN KLPLLIYIHG GAWIIESPFS PLYHNYLTEV VKSANCLAVS VQYRRAPEDP
     VPAAYEDVWS AIQWIFAHSN GSGPVDWINK HADFGKVFLG GDSAGGNISH HMAMKAGKEK
     KLDLKIKGIA VVHPAFWGTD PVDEYDVQDK ETRSGIAEIW EKIASPNSVN GTDDPLFNVN
     GSGSDFSGLG CDKVLVAVAG KDVFVRQGLA YAAKLEKCEW EGTVEVVEEE GEDHVFHLQN
     PKSDKALKFL KKFVEFIIG
//
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