ID D0A3H2_TRYB9 Unreviewed; 437 AA.
AC D0A3H2;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN ORFNames=TbgDal_X9070 {ECO:0000313|EMBL:CBH15816.1};
OS Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH15816.1, ECO:0000313|Proteomes:UP000002316};
RN [1] {ECO:0000313|Proteomes:UP000002316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA Barry J.D., Berriman M., Hertz-Fowler C.;
RT "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT chronic human african trypanosomiasis.";
RL PLoS Negl. Trop. Dis. 4:E658-E658(2010).
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DR EMBL; FN554973; CBH15816.1; -; Genomic_DNA.
DR RefSeq; XP_011778080.1; XM_011779778.1.
DR AlphaFoldDB; D0A3H2; -.
DR GeneID; 23866029; -.
DR KEGG; tbg:TbgDal_X9070; -.
DR VEuPathDB; TriTrypDB:Tbg972.10.9070; -.
DR OrthoDB; 208457at2759; -.
DR Proteomes; UP000002316; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45969; RING ZINC FINGER PROTEIN-RELATED; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 33..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 284..325
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 437 AA; 48731 MW; 872FE32C4421B325 CRC64;
MTPLQVLFIL LGVAVVAQWN LLLRLPQTVV AAVWLAVMTA VISASWSTML LVERVCGLCE
ANAHGQLVNP SSSGTPLRKT VFMALFYPLL LTFSAGVSVT LAWRDSLLLG GVASGCVAFL
EQQLEMWPRR RDLKFRVVSC TLCGFALFCT ALLWSFHVTS PREESSMGSL AQFAVIMWTA
ALTTGLLKLL LFATLHAWHT SNVLTGRAGS VDFDPMEEVG LSIRICCSLI LLVVSGEHLP
NFTGILVHVV VLAPFLDVLY AASILFRFRH VVDSFPEVGT AADCVICFDP VTDSARGRQL
RCGHIFHSRC LRRWLMRAAR CPTCRQYVFH QENALFPVEL FYDFRANIRH RGVGDEDAQR
GGGRGSCHMP GGVLACKHLF TKAYSLSGVM HHPALWPFLQ VLQWRPLWAT VLHLPMRSLS
RRACRLFGLQ RRRLGRR
//
