ID   D0A541_TRYB9            Unreviewed;       922 AA.
AC   D0A541;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Probable helicase A859L {ECO:0000256|ARBA:ARBA00019253};
GN   ORFNames=TbgDal_X14830 {ECO:0000313|EMBL:CBH16385.1};
OS   Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH16385.1, ECO:0000313|Proteomes:UP000002316};
RN   [1] {ECO:0000313|Proteomes:UP000002316}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX   PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA   Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA   Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA   Barry J.D., Berriman M., Hertz-Fowler C.;
RT   "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT   chronic human african trypanosomiasis.";
RL   PLoS Negl. Trop. Dis. 4:E658-E658(2010).
CC   -!- SIMILARITY: Belongs to the asfivirus helicase A859L family.
CC       {ECO:0000256|ARBA:ARBA00007303}.
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DR   EMBL; FN554973; CBH16385.1; -; Genomic_DNA.
DR   RefSeq; XP_011778649.1; XM_011780347.1.
DR   AlphaFoldDB; D0A541; -.
DR   GeneID; 23864696; -.
DR   KEGG; tbg:TbgDal_X14830; -.
DR   VEuPathDB; TriTrypDB:Tbg972.10.14830; -.
DR   OrthoDB; 160114at2759; -.
DR   Proteomes; UP000002316; Chromosome 10.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   CDD; cd18785; SF2_C; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR018306; Phage_T5_Orf172_DNA-bd.
DR   PANTHER; PTHR11274:SF13; HELICASE A859L-RELATED; 1.
DR   PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF10544; T5orf172; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00974; T5orf172; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000313|EMBL:CBH16385.1};
KW   Helicase {ECO:0000313|EMBL:CBH16385.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000313|EMBL:CBH16385.1};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..922
FT                   /note="Probable helicase A859L"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003006235"
FT   DOMAIN          228..407
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   REGION          864..885
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   922 AA;  105384 MW;  C1F2D4BEC922E57A CRC64;
     MVRLTVLVRC GLGFYVAVHP WLTGSGYVKV GCTADFTRRL EMASFTTCFT PEWSYYAVFR
     CESMKEAFLL EQAVLFLFKE RRVPQRELIK GNAQDVTEGA RRVCSTLNLN ALVNMAPVYT
     EKNSLPPDYA SSGRISTEKN SRREAEAPKL HTLEKYMGSL EKLRESMVSL NSPCDASTDD
     DIFNSVETGD GEDYEIGCDF EVVDALGEET FSLAALRPYQ KDAVARCLEQ LDSCGATICQ
     MACRCGKTPV AYDLIRRHLE MKPNSIILYL VPGLALLRQT ARKLYSYGLK DVPFLLIGSD
     SGSIFLGDGC VRNMTTDAEL IRSTISSCAS HLIVISTYQS SHIISKMPNF ALTVFDECHR
     VCGSDLPTNF NNVLLQPRCG RRLFLTATPA YDTPLKMDNT FLFGDIAYRY YLREGIDAGY
     VNPFAVRIVL GESMDDMNPY FYEAMNTVDK MIVYCRCIEH ATKLAADLKH PLPDDITPFD
     VLLAHSRMGS AAVASVLRDF SASRRCILLN VRLLQEGVEI PDLNAVFFAA PRYSSRDIVQ
     SICRPLNKME NKPISYVFLP ATINKRLPED HPVNLEKFST LVPFTDALMD EDPLLFEYLI
     DPHKVSYDVD VVGVRSLKLS SERLRRFVLP AIRRGVRYSS QNTDRLHRAT RLPWKNAFNE
     MKRIVLECNR YPKTNDAWVI GKKSVSMALF YRYCRKGYRQ YLDKEPSCLR MHQIRDLESL
     PLWRTYGLHG PYPWEECLNT LREYLEAHGS VPPLDVHKGG YIGLDATPFE RLCGVLMHVN
     QCDACTKLRL DPAKQKQLDR LCKPFGLKWK KGRDKDGKIL PGEATFITDS YDRFKALYED
     RQKNNFQEYL DSHFPGYPLK HERMEDPRNL RKDRVPPRHV SRDEVTNPHK AGKVMCRVCR
     RNVAVRVWEQ HLKSKAHRQN MK
//