ID D0A5A4_TRYB9 Unreviewed; 336 AA.
AC D0A5A4;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=N-alpha-acetyltransferase 60 {ECO:0000256|ARBA:ARBA00026144};
DE EC=2.3.1.259 {ECO:0000256|ARBA:ARBA00026111};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN ORFNames=TbgDal_X15470 {ECO:0000313|EMBL:CBH16448.1};
OS Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH16448.1, ECO:0000313|Proteomes:UP000002316};
RN [1] {ECO:0000313|Proteomes:UP000002316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA Barry J.D., Berriman M., Hertz-Fowler C.;
RT "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT chronic human african trypanosomiasis.";
RL PLoS Negl. Trop. Dis. 4:E658-E658(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00000780};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] =
CC CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane
CC protein]; Xref=Rhea:RHEA:50604, Rhea:RHEA-COMP:12745, Rhea:RHEA-
CC COMP:12746, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:64731, ChEBI:CHEBI:133414; EC=2.3.1.259;
CC Evidence={ECO:0000256|ARBA:ARBA00024450};
CC -!- SIMILARITY: Belongs to the acetyltransferase family. NAA60 subfamily.
CC {ECO:0000256|ARBA:ARBA00025774}.
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DR EMBL; FN554973; CBH16448.1; -; Genomic_DNA.
DR RefSeq; XP_011778712.1; XM_011780410.1.
DR AlphaFoldDB; D0A5A4; -.
DR GeneID; 23864766; -.
DR KEGG; tbg:TbgDal_X15470; -.
DR VEuPathDB; TriTrypDB:Tbg972.10.15470; -.
DR OrthoDB; 119846at2759; -.
DR Proteomes; UP000002316; Chromosome 10.
DR GO; GO:0004596; F:peptide alpha-N-acetyltransferase activity; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR045141; NAA60-like.
DR PANTHER; PTHR14744; N-ALPHA-ACETYLTRANSFERASE 60; 1.
DR PANTHER; PTHR14744:SF15; N-ALPHA-ACETYLTRANSFERASE 60; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CBH16448.1}.
FT DOMAIN 105..155
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00583"
SQ SEQUENCE 336 AA; 37107 MW; 978B68FC0A4D49B4 CRC64;
MSAVELVALP SRNGGRPLTV HLSWGIAESD MESIQALHAI SFPVEYPDDY YNWLRSGSSV
AIVAHVSHRD VVMDPHDTHS GVETELSTEG GVVEPPLVYS CLAGFCIGQL GHKRYEDGQL
EPSPTGYLMS FAVDPRLRRR GVGELLLTRF LTYMFFIIPV PPLIRAGNGG LSLGKALAPV
LKGFFTAVSS FLQQRLGIES HSEQLNNPPR DPKTLPDRPI DAGHSNLRCG VGEVWLHCLA
SDEALLRFYS SRGFMRVRVI RGFYMFDARL HDGMLLVIRR GDFSSLGNAV LQHGVCRYKQ
ASTDSVRLRT DLTDGGEIVG LDEDLARVAD IELFRS
//
