ID D0A6K8_TRYB9 Unreviewed; 364 AA.
AC D0A6K8;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
DE Flags: Fragment;
GN ORFNames=TbgDal_XI4270 {ECO:0000313|EMBL:CBH17309.1};
OS Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH17309.1, ECO:0000313|Proteomes:UP000002316};
RN [1] {ECO:0000313|Proteomes:UP000002316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA Barry J.D., Berriman M., Hertz-Fowler C.;
RT "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT chronic human african trypanosomiasis.";
RL PLoS Negl. Trop. Dis. 4:E658-E658(2010).
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DR EMBL; FN554974; CBH17309.1; -; Genomic_DNA.
DR RefSeq; XP_011779573.1; XM_011781271.1.
DR AlphaFoldDB; D0A6K8; -.
DR GeneID; 23867416; -.
DR KEGG; tbg:TbgDal_XI4270; -.
DR VEuPathDB; TriTrypDB:Tbg972.11.4270; -.
DR OrthoDB; 5472610at2759; -.
DR Proteomes; UP000002316; Chromosome 11.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR004493; Leu-tRNA-synth_Ia_arc/euk.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR PANTHER; PTHR45794:SF1; LEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR45794; LEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000313|EMBL:CBH17309.1}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CBH17309.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 17..95
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT NON_TER 364
FT /evidence="ECO:0000313|EMBL:CBH17309.1"
SQ SEQUENCE 364 AA; 41558 MW; 497F358D8714C561 CRC64;
MSTVRRDRLV SIEAEAQARW SKEKIYELDA PLKGEETQPK FFTTFPYPYM NGRLHLGHTF
SLTKCEFATR FWRMKGYRSL WPFGLHVTGT PIAACAQKIK LEMELYGNPP QFPAEVEDKP
LEKKDEVATI GQHKGKRGKA GPAKPQWIIM RTMGIEESEI PKFADPLHWF DFFPPLAIQD
LKRLGCHIDY RRSFITTDRN PYYDRFVSWQ FRNLRSSNYL HYGKRYCIYS PLDKQPCADH
DRASGEGALP QEYTVVKLKV KNPLEQPALA PFSEIIGNRS VILPGATLRP ETVIGQTNCW
VSPNFSYMAY SILNGTGDEE IYIMTSRAAR NLAYQNFTVN GKTGVDPSPL FEVDGAKLIG
LPLS
//
