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Database: UniProt
Entry: D0DAB6_9RHOB
LinkDB: D0DAB6_9RHOB
Original site: D0DAB6_9RHOB 
ID   D0DAB6_9RHOB            Unreviewed;       556 AA.
AC   D0DAB6;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   05-JUL-2017, entry version 50.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EEX12991.1};
GN   ORFNames=CSE45_3477 {ECO:0000313|EMBL:EEX12991.1};
OS   Citreicella sp. SE45.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Citreicella.
OX   NCBI_TaxID=501479 {ECO:0000313|EMBL:EEX12991.1, ECO:0000313|Proteomes:UP000005759};
RN   [1] {ECO:0000313|EMBL:EEX12991.1, ECO:0000313|Proteomes:UP000005759}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SE45 {ECO:0000313|EMBL:EEX12991.1,
RC   ECO:0000313|Proteomes:UP000005759};
RA   Buchan A., Ferriera S.F., Johnson J.J., Kravitz S.K., Beeson K.B.,
RA   Sutton G.S., Rogers Y.-H.R., Friedman R.F., Frazier M.F.,
RA   Venter J.C.V.;
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; GG704601; EEX12991.1; -; Genomic_DNA.
DR   STRING; 501479.CSE45_3477; -.
DR   EnsemblBacteria; EEX12991; EEX12991; CSE45_3477.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000005759; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005759};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005759}.
FT   DOMAIN      248    378       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      464    533       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     256    263       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   556 AA;  61956 MW;  5566B54D00C4944D CRC64;
     MKPRLRQSAV TAVGTGRKPC QSEHIQSAES ASQATFAQGS KGGSGVVSGQ GCVSPQPMLP
     RHGAAEYCQA TCFVGRHAQG APGRRVEHMA RSFRSGDRMT KEQWGALQDQ LSSTIGENNY
     KTWIQPIEFH GIEPGGIAVF NVPTNFIGTY VSQNFGELLL AKLASMDSEI RRLKFQVANV
     DTRPSQQPRP APTAGSAAST QTATATSGDV LPGAPLDARF TFDSFIVGKP NELAHAAAKR
     VAEGGQVTFN PLFLYGGVGL GKTHLMHAIA WDLRNHRPDL NVLYLSAEQF MYRFVQALRE
     RRMMDFKELF RSVDVLMVDD VQFIAGKDST QEEFFHTFNA LVDQNKQIII SADRAPDEIK
     DLENRIRSRL QSGLVVDLHP TDYELRLGIL QSKVQNYRLQ YPSLQLDDGI LEFLAHRIST
     NVRVLEGALT RLFAFASLVG QPITMELTQD CLADVLRASD RKISIEEIQR KVAEHYNIRL
     SDLIGPKRVR NFARPRQVAM YLCKQLTARS LPEIGRRFGG RDHTTVMHGV KRIEELRTQD
     SQIADDVELL RRALEA
//
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