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Database: UniProt
Entry: D0J7K7_COMT2
LinkDB: D0J7K7_COMT2
Original site: D0J7K7_COMT2 
ID   D0J7K7_COMT2            Unreviewed;       468 AA.
AC   D0J7K7;
DT   15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2009, sequence version 1.
DT   25-OCT-2017, entry version 64.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=CtCNB1_0001 {ECO:0000313|EMBL:ACY30747.1};
OS   Comamonas testosteroni (strain CNB-2).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Comamonas.
OX   NCBI_TaxID=688245 {ECO:0000313|EMBL:ACY30747.1, ECO:0000313|Proteomes:UP000002360};
RN   [1] {ECO:0000313|EMBL:ACY30747.1, ECO:0000313|Proteomes:UP000002360}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNB-2 {ECO:0000313|Proteomes:UP000002360};
RX   PubMed=19734336; DOI=10.1128/AEM.00933-09;
RA   Ma Y.F., Zhang Y., Zhang J.Y., Chen D.W., Zhu Y., Zheng H., Wang S.Y.,
RA   Jiang C.Y., Zhao G.P., Liu S.J.;
RT   "The complete genome of Comamonas testosteroni reveals its genetic
RT   adaptations to changing environments.";
RL   Appl. Environ. Microbiol. 75:6812-6819(2009).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001220; ACY30747.1; -; Genomic_DNA.
DR   RefSeq; WP_003064795.1; NC_013446.2.
DR   STRING; 688245.CtCNB1_0001; -.
DR   EnsemblBacteria; ACY30747; ACY30747; CtCNB1_0001.
DR   KEGG; ctt:CtCNB1_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000002360; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002360};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002360}.
FT   DOMAIN      165    299       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      376    445       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     173    180       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   468 AA;  52818 MW;  EBFCB1D87BA26202 CRC64;
     MTEEPTNDAG QALWQVCVEQ LGQELPEQQF NTWIKPLTAL VAEDFSKVTV YVANRFKLDW
     IRAQYAGRIS AMLESLYGQP VTLELALAQR ESVVRTYVRP PSSTQQAAPQ THNVAVPTVT
     SEEASAPVFR TRLNPALTFE TLVEGTANRM ARSAAMHVAG SPGHLYNPLF IYGGVGLGKT
     HLVHAVGNQL LKDKPDAKIL YIHAEQFVSD VVKAYQRRTF DEFKERYHSL DLLLIDDVQF
     FANKDRTQEE FFNAFEALLA KKSHIVMTSD TYPKGLANIH ERLVSRFDSG LTVAIEPPEL
     EMRVAILINK ARAENADMPE EVAFFVAKNV RSNVRELEGA LRKILAYSRF NQKEVSIQLA
     REALRDLLSI QNRQISVENI QKTVADYYKI KVADMYSKKR PASIARPRQI AMYLAKELTQ
     KSLPEIGELF GGRDHTTVLH AVRKIAGERQ TNTELNQQLH VLEQTLKG
//
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