ID D0LEZ9_GORB4 Unreviewed; 1632 AA.
AC D0LEZ9;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Gbro_2642 {ECO:0000313|EMBL:ACY21873.1};
OS Gordonia bronchialis (strain ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198
OS / KCTC 3076 / NBRC 16047 / NCTC 10667) (Rhodococcus bronchialis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=526226 {ECO:0000313|EMBL:ACY21873.1, ECO:0000313|Proteomes:UP000001219};
RN [1] {ECO:0000313|Proteomes:UP000001219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198 / KCTC 3076 /
RC NBRC 16047 / NCTC 10667 {ECO:0000313|Proteomes:UP000001219};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Ovchinnikova G., Saunders E., Brettin T., Detter J.C., Han C., Larimer F.,
RA Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T.,
RA Wu D., Jando M., Schneider S., Goeker M., Klenk H.-P., Eisen J.A.;
RT "The complete chromosome of Gordonia bronchialis DSM 43247.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACY21873.1, ECO:0000313|Proteomes:UP000001219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198 / KCTC 3076 /
RC NBRC 16047 / NCTC 10667 {ECO:0000313|Proteomes:UP000001219};
RX PubMed=21304674;
RA Ivanova N., Sikorski J., Jando M., Lapidus A., Nolan M., Lucas S.,
RA Del Rio T.G., Tice H., Copeland A., Cheng J.F., Chen F., Bruce D.,
RA Goodwin L., Pitluck S., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Chain P.,
RA Saunders E., Han C., Detter J.C., Brettin T., Rohde M., Goker M.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P.,
RA Kyrpides N.C.;
RT "Complete genome sequence of Gordonia bronchialis type strain (3410).";
RL Stand. Genomic Sci. 2:19-28(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP001802; ACY21873.1; -; Genomic_DNA.
DR STRING; 526226.Gbro_2642; -.
DR REBASE; 22321; GbrORF2642P.
DR KEGG; gbr:Gbro_2642; -.
DR eggNOG; COG0286; Bacteria.
DR eggNOG; COG1111; Bacteria.
DR eggNOG; COG4889; Bacteria.
DR HOGENOM; CLU_002151_1_0_11; -.
DR OMA; FDATINK; -.
DR Proteomes; UP000001219; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd22333; LlaBIII_nuclease-like; 1.
DR CDD; cd18785; SF2_C; 1.
DR Gene3D; 3.40.1350.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR039442; Mrr-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR011856; tRNA_endonuc-like_dom_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR47396:SF1; ATP-DEPENDENT HELICASE IRC3-RELATED; 1.
DR PANTHER; PTHR47396; TYPE I RESTRICTION ENZYME ECOKI R PROTEIN; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF13156; Mrr_cat_2; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001219}.
FT DOMAIN 183..382
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 680..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1632 AA; 180453 MW; B15A5AC9D97A5603 CRC64;
MSMASVHDVI EAFRKEPTNS ERGTKFEQLM VRYFELDPTM AQQYDGVWRW IDWPGRQGKP
DTGIDIVARE RDTGDYTAIQ CKFYEPTHTL AKGDIDTFFT ASGKAGFTNR VIISTTDRWG
RNAEDAITDQ QIPVQRIGLA EIAESPIDWD IAWPQGELQV ELTPAVRHQP RPHQQQAIDA
VFDGFAAGND RGKLIMACGT GKTFTALKIA ERTAAENGGS ARILFAVPSI SLLSQTLREW
TAQTETDIRA FAVCSDTKVS RAAEDVSVVD VAIPVTTDGP TLAAHMEHRK RARGLTVVFT
TYQSLPAVAD AQNRGVDPFD LVICDEAHRT TGVTVSGADE SNFVKVHDDD FLHAHRRLYM
TATPRIFADT VREKAEEHSA ELTSMDDMDI YGPEFHRLSF GDAVDRGLLT DYKVIVLTVD
EGLVAAPMQK QLAGEFAELQ LDDASRIVGC WNGLAKRAGT TPDGTGFAPD EPPMRRAVAF
AKDIAASKQV AEVFPAVVDA YRDLLDDTDP LNDATGNRDL TVSARHVDGT MNALQRNEAL
RWLRSGSIGD DECRILSNAR CLSEGVDVPA LDAVLFLHPR NSVVDVVQSV GRVMRLSPGK
DYGYIILPVA VPSGVSPAAA LSDNRRFKVV WQVLNALRAH DDRFNAMVNS IALNAATQQA
GLGKGNDRLL GGHIGPVADD TDSIGGDSAS PGASGDDGTG DHDVATQLAL FSLSEWQEAI
YARIVDKVGT RVYWEQWAAD VADIAAAQIT RINALLADAD HAVTQRFELF VQALRDNLND
SVSRDDAISM LSQHLITKPV FDALFAGHEF AAHNPVSIVM QQMIDTLDDA NLESETSGLE
KFYQSVRIRA SEVTSADGKQ QVIAELYERF FRVAFRKQAD ALGIVYTPTE IVDFILRAAD
HVSRDTFGRG LTDDGVHILD PFTGTGTFLT RLLQSGLILP HDLGRKYRNE LHANEIMLLA
YYIAAVNVET TYHALTTPDG ETGTYEPFEG IVLADTFQIT EDDDSMDSIM FPQNNLRIEK
QLAAPINVIV GNPPYSVGQD SANDMNANIK YPTLDARIAD TFAARSTGTN KNSLYDSYYR
AYRWATDRIG DTGIVAFVSN GGWIDGNTAD GVRLTLAREY AHLWVYNLRG NQRTAGELSR
REGGKVFGAG SRSTITIFIG VKDPTHTGPC QIHYRDIGDY LSREDKLRII NADRIETMDW
QPIAPNEHGD WINQRNDEFS SWPVIGAKDG GSSAVFASYS SGLKTGRDAW VYNWSDTALH
NSVAELMRQY RQVEELYAQR TTGSLDDVFA THPELTGSGM ISWNRSLRQQ IMRGASLEIS
EASFRAGSYR PFASQHVYFD KSTSDMVYRL PSMFPTPHHH NVGYYIVGTG SDKPFSVLAT
NRIPDLSFWG SGSGQFFPRF TYEHVDAVAA SGELDFGSAA DVVDVDEHGY RCIDNITDGI
LARYRRALGD SVTKDQIFWS VYGQLHVPSY RETYAGDLKK MLPHIPIPDS RARFDQLAQV
GEQLGHLHMR YEDVDPYPLD VQLKPGAGPG DPETWRVQKM KWRSKTDHTA IIYNTKVTIG
GIPPEAEEYL LGARSALAWI IDRYQVKTDK ASGIVNDPNL WCDEHNDPTY ILDLIKKVTT
VATETVKIVK DL
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