ID D0LUN1_HALO1 Unreviewed; 6403 AA.
AC D0LUN1;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Amino acid adenylation domain protein {ECO:0000313|EMBL:ACY13921.1};
GN OrderedLocusNames=Hoch_1367 {ECO:0000313|EMBL:ACY13921.1};
OS Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2).
OC Bacteria; Myxococcota; Polyangia; Haliangiales; Kofleriaceae; Haliangium.
OX NCBI_TaxID=502025 {ECO:0000313|EMBL:ACY13921.1, ECO:0000313|Proteomes:UP000001880};
RN [1] {ECO:0000313|EMBL:ACY13921.1, ECO:0000313|Proteomes:UP000001880}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14365 / CIP 107738 / JCM 11303 / AJ 13395 / SMP-2
RC {ECO:0000313|Proteomes:UP000001880};
RX PubMed=21304682; DOI=10.4056/sigs.69.1277;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Ivanova N., Daum C., Lang E., Abt B., Kopitz M., Saunders E., Lapidus A.,
RA Lucas S., Glavina Del Rio T., Nolan M., Tice H., Copeland A., Cheng J.F.,
RA Chen F., Bruce D., Goodwin L., Pitluck S., Mavromatis K., Pati A.,
RA Mikhailova N., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA Jeffries C.D., Detter J.C., Brettin T., Rohde M., Goker M., Bristow J.,
RA Markowitz V., Eisen J.A., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Haliangium ochraceum type strain (SMP-2).";
RL Stand. Genomic Sci. 2:96-106(2010).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP001804; ACY13921.1; -; Genomic_DNA.
DR RefSeq; WP_012826530.1; NC_013440.1.
DR STRING; 502025.Hoch_1367; -.
DR KEGG; hoh:Hoch_1367; -.
DR eggNOG; COG0318; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_222916_0_0_7; -.
DR OrthoDB; 5349841at2; -.
DR Proteomes; UP000001880; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 2.
DR CDD; cd12116; A_NRPS_Ta1_like; 1.
DR CDD; cd17651; A_NRPS_VisG_like; 1.
DR CDD; cd05931; FAAL; 1.
DR CDD; cd19531; LCL_NRPS-like; 5.
DR Gene3D; 3.30.300.30; -; 6.
DR Gene3D; 3.40.50.980; -; 8.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR040097; FAAL/FAAC.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 6.
DR Pfam; PF13193; AMP-binding_C; 5.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 6.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 6.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 6.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 6.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001880}.
FT DOMAIN 612..686
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1690..1765
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2759..2834
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3837..3912
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4911..4986
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6008..6083
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 577..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1669..1691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2740..2763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6366..6403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6403 AA; 688705 MW; 530E5508DAB3B6A1 CRC64;
MTDHLNASGH WTTLIELLRE RAELDAGYTF LLDGEQREAK RSFAALDTHA RRIAATLQRA
GAEGERAVLL YPPSLDYIDA FFGCLYGNVV AVPAYPPDPT RLQRTLPRLQ AIVADAGASI
ILTTRAIQTM AKAISAFAPE LADKQWIATD AIEPGAEDAW AAPAVSGDST AFLQYTSGST
GRPKGVIVSH RNILANETMI QRGFETGPDS MGVGWLPLYH DMGLIGNVIQ PLCAGFSIAL
MSPLDFLRRP MRWLQAVSRY RATVSGGPNF AYDLCVRKST PEERAALDLS AWRVAFSGAE
RVRPETLKRF VDAFGPQGFR WQAFYPCYGL AEATLLVTGG RRDAMPVVHE FHTGALEAGR
AEDEIIPSTG QALVGVGGAV EGPEPIVVDP ETRTRVPERA IGEIWVQGPH VAGGYWGCPE
ESERVFRARL AEDDGAVYLR TGDLGFLRAG ELYITGRLKD LIILRGRNLF PDDIERALES
SHDAIRPGCC AAFAVERQGE ERLVVALELA RGAEGQVDEV ARAVRAAVAS QLDVQVHTVA
LLRAGTIPKT SSGKIQRHAC RQGFLAGSLE LLAPAGADAQ AEEGGGASTA DERAGSGSGE
GAGDGSVDGP GDVDAERLCA VVARVLDRPR EQITPQMSAV ALGVDSLGAV ELAYEIERHF
GVPVPGTLFL RDVSLAALAE ELAAQSTGAA MPELAELSAD APGVSHNQAS LLFLQELEPS
STAYNVCAAF RIRSQVDDDA LAAAFTALVR RHPILRTRYQ RGADGFTAVL DEAARVALRV
VDAPDADSEA TRALVAEDAL RPFDLQAEPV LRVSLFRHEP RLHTLSVTVH HVAVDYWSLV
LLMSELGELY QAARSGAELD DALPPASVHY AQFAAWQRAL LEGPEGERLA DFWAAELAET
RPPLDLGRPR RSPGAGRGGM HTFILDRELG AGLRRLAEAA GVTPYTVLLA GFQVLLSRYA
GQQQFVVGTP ALGRTHHALD RTVGYFVNLL PIAAELSDAP SVRALLARVR DTVVRALEHQ
AYPFARMVEG RGGDRQSGRM PLVQAAFVFE KPHLQADAAL SAVAFGQPGA RAELGGMALE
PVSPAQRADL VTSPQFELLL QVFDSGEEMI GQASYDADLF DEEQVARMCG HFEAVLRAMV
ADVEQPAAAV SLLAADERAQ VVEEWNATAV DYGAAQALHE LVEAQVARTP EQVAVVFGER
SLSYRELDGW ANRVARELRG RGVGVDARVG VYMERSLELM VALLAIAKAG GAYVPLEPTH
PAARVAHLVQ DTGALLVLAQ GPVPGEVCAA DKVLVVDAEL GAGQAETALG VAVPPEALAY
VLYTSGSTGQ PKGVMNSHAG ISNRLRWMQA EYELGGEDVV LQKTPFTFDV SVWEFFWPLM
TGARLVLAAP GKHTDAAYLS AVIGEHGVST MHFVPSMLAL FLRDAELAAC QGLERVICSG
EALSAELCQQ TQAALPNAGL HNLYGPTEAA VDVSFWDCGA NSDGRPVPIG RPVANTTLYV
LDAAMQPQPV GVPGELYIGG VQVARGYQGQ PARTAERFVP DPFASTPGGR LYRTGDRARL
RGDGAIEYLG RLDHQVKLRG VRIELGEVEA ALQAVAGVDQ AVAVVREDVL GEPSLVAYVV
AATAAEAEAA AELTPGALRE ALRARLPEAM VPGPIVFVPA LPLTASGKLD RKALPRPEAP
TSAEGDADAA PRTATERALA ELWQELLGAD RVGVNDDFFQ LGGHSLLAAQ LIARVRRAFD
VELPLRAIFD APTVAALAAR LASASKALAP AAIPQIARDG ELPLSFGQER LWFLDQLGSG
TAYNMGAALR LRGRLNADAL ARALQEVVQR HEVLRTSFPA ADGRPRPSIA ATAELTLAHL
DLRGESGDMD QRLAALAEAH AAERFDLARG PLLRASLVRT GEDEHVLLFV MHHITSDGWS
LRVLGRELGA LYAAFAAGQA SPLPPLPIQY ADYAAWQRAA LASDSARQQL AYWRQTLAEV
PGALELPTTE RVRPAVQSYR GRVVHARVSE ELGQALRELS RERGVTLFMT LMAGFQVLLS
RYAGQQRFAV GTPVANRAHG DLEQLIGFFV NSLALPADLV PASPDQALTC AALLARVRDA
AVGAYAHQEV PFEKVVEVLG VERDPSRSPV FQVMLSYEPA ARLELALPGI EAEELAFPTG
DAKLDMTWLM SDGGAGALQL MVEYNADLFD EEQVARMCGH FEAVLRAMVA DVEQPAAAVS
LLAADERAQV VEEWNATAVD YGAAQALHEL VEAQVARTPE QVAVVFEGRS LSYRELDGWA
NRVARELRAR GVGVDVRVGV YMERSLELMV ALLAIAKAGG AYVPLEPTHP AARVAHLVQD
TGALLVLAQG PVPGEVCAAD KVLVVDAELG AGQAETALGV AVPPEALAYV LYTSGSTGQP
KGVMNSHAGI SNRLRWMQAE YELGGEDVVL QKTPFTFDVS VWEFFWPLMT GARLVLAAPG
KHTDAAYLSA VIGEHGVSTM HFVPSMLALF LRDAELAACQ GLERVICSGE ALSAELCQQT
QAALPNAGLH NLYGPTEAAV DVSFWDCGSN SDGRPVPIGR PVANTTLYVL DAAMQPQPVG
VPGELYIGGV QVARGYQGQP ARTAERFVPD PFASTPGGRL YRTGDRARLR GDGAIEYLGR
LDHQVKLRGV RIELGEVEAA LQAVAGVDQA VAVVREDVLG EPSLVAYVVA EAATEAETAA
ELSPGALREA LRARLPEAMV PGPIVFLAAL PLTASGKLDR EALPRPEAPT SAESDADAAP
RTASERALAE LWQELLGADR VGVNDDFFQL GGHSLLAAQL VARVRRAFEI ELPIAALFTA
PTVAALARHI DDIRAERAAS GHAERDWPSM PPLAPRAEAG PIPLSYEQER LWFLQQLYPS
SPAYNMFGAV RMHGPLDGDA FARALDEVVC RHESLRTTID APLGPPRQVV HEHQPAPLQL
IDLSHHGDPQ SALAQRIQRE AQQPFDLERG PLLRVRLVRE RADSHVLLVC MHHIISDGWS
IGVFVRELAA LYDAYAADQT AKLPELRVQY ADYAVWQRAW LTGEVLAQQM QFWRDQLAGI
PTALELPTDY PRPSAPSFRG ARHRFTIAPA LSQAVADFSQ QRGVTRFTTL MAAFATLLHR
YAGQRDIAVG TPVANRPEVE TEQLIGFFAN SLVLRTRFDD DPTVAELIAQ VHRTSLDALA
HQQVPFAQLV AELQPNRDTS LSPLFQVMFG LQNTPAAPAA LTGLRWQPIE VDEQSTSFDL
SLMLEEHDGG FRGTLDYSSD LFAPATMERF AAHLLRLLGD MLARPHARVS QLALLADWER
ERLAEWNDNR VEHRITGLVH DLFDEQVQAT PDAIAVTYEG ARLSYAELDR RANRVAHRLI
AMGVRPEHRV AICLPTSLEV IVGSLGIVKS GGVVLPLDPD YPQERLELLL SESDARVVIG
DARVRALLAA ASTSGLAALP FVDIADLGPA AAQDDASWER APATSVHPDN AVYLFYTSGS
TGKPKGVLVT HRGIANELAA ERLTYGLRPG QGVLMATSVS FDMSLSQIYP PLIQGATLVI
ARPMSTEDAS YLLRLIRDEN VVLASFVPSL LAVLMDDPAF DECRNLGHIQ ACGEALLPEL
VQRFYGRTPA TLWNCYGPTE VSIGITIGEV PRQLEATQGT AVTIGGPIPN IQAYVLDEHL
QPLPIGVPGE LYLGGVGLAR GYLNAPGRTA QSFVPDPFAS APGQRMYRTG DLARFREDGN
LECLGRVDDQ VKVRGYRIEL GEVESVLGQH ASVREAVAAA FDRGDGNKIL VAYVEPREQQ
DIDMAALRRY LGGRLPSYMV PTRIVQMDEM PRSASGKINR RALPAPELGH SDRAYVAPRS
AVEITLAQLW AALLGAERVG LEDDFFEFGG HSLLATQLVS RVRATFGIEI PLRALFETRT
LAAFAREVER HANIGPRVAP PVTPVSREGE LVLSFGQERL WVLDQLDRST AYNMPGAIRL
SGRLEHRALE RALDEMVRRH ESLRTVFEGR DGRPVQRILP PFTLALPVLD LRGHADREQR
ALGYIHEVVE EPFDLARGPL VRGALVHVEP DEHVLVFAMH HIVSDGWSLA VFARELGALY
AAYAAGQPSP LAEPAIQYAD YAAWQRAWLD QERVEEQLAY WKQQLAGAPA ALELPLDRPR
PPRQSFRGAY LTRPISNALS EAVAELARRE GATLFMTLLA AFQSLLARYA GQDDVVVGTP
IANRRQQETE ELIGFFVNTL ALRTDVAGEP SFRELLARVR DVTLGAYANQ DLPFERLVDE
LLPQRDLSRS PIFQVLFAVQ NTPWEPLVLS DIALSHVDVE PNTAKFDIEL SVVETETGLL
ATYNYCTDLF DERTIERMHG HLVNLLRAVV ADPEQSIASV SLLDAAEQQT VVLDWNQTRA
PLPGQCVHHA VLARAAAQPE AIALRHGDQQ LSYAELRARA GRLARHLRSL GVGVDEPVAL
YVHRSFDMIV GLLGILEAGA CCVPLDPAYP QQRIEFILGD SRARVVVTQE PLAELLPAGA
PQSVRLDRDA AALAGPDSDS DGDALEVAVS LENLVYLIYT SGSTGKPKGV AMTHAALANL
MDWQARESSA GAGRTLQFAP LSFDVSFQEV FSTLGQGGTL VLVDEDTRRD FRALLQLIDE
QSVNRVFMPF VALRGIAEVA RGQRLPPALR EVITAGEQLQ ITPALEALFA TDEAADGERA
PRVLVNQYGP SETHVATSYT LSGPPDRWPR LPPIGAPVAN ARAYVLDSAM HPVPVGVSGE
LYLGGTCVAR GYLERPGLTA ERFVPDPFAD ADAPGARLYR TGDLARYRAD GAIEFLGRVD
RQAKIRGYRV ELGEVETALG AHPAIADAAV LAREDASGAK RLIAYLVARP GESVDVRQLA
DALGSALPEY MVPSAFVLMH ALPLTPSGKV AHALLPPPEM ARDEDDEEFV APRAGMEERL
AAVWRELLEM DGIGARDNFF ELGGHSLLAT QLMARVLRDT GVDLPPRTVF EAPTIEELAA
LVDAALPAAQ ASETEVEAET GQVSGEVSGQ VSGQVSEIDP ESAAAAPAAG GRFVTQRGHT
GDVPLAFAQE RLWFLDQLEP SAAYNLVGAF RMSGSLSLPA LAHALSGVVH RHEILRTTFP
AVDGQPVQRI ASALVLPLPV FDLSAAAEPR AEVARQLAEE AGTRFDLARG PVLRVRLLRT
GEREHVLIFA MHHIVADGWS MSILAREVAA LYEAHLRDRE SALPPLPIQF ADYALWERAH
LQGQVIDEHI AYWRQALAGA PTALELPTDR PRPAMQTSAG AHLSFEVPAE LSARLRALGS
EHGCTLFMTV LAAFQVLLAR CAGQDDVLVG APVANRNRAE AEGLIGCFIN TMVVRGRLSE
NPRFRDFLAQ VRETTLGAQA HRAAPFALVV DALDLPRDLS RSPLFQVMFA LHNLPPDRLE
LPGLTLEPVQ DEMPFARFDL ALDLWESRAG LRGSMEYNTA LFDEATIARL CAQLSHVLAA
VVAAPDTPVA DIPLMPREAS LRQLAQWNDS ARAVDFELSI TARIAAQAER QPQATALACG
AQELSYGALI ARVRQLAHAL RGMGVGPERL VGVYLERSID MVVAVLAVLE AGGAYLPLDP
AYPGERLAYM IADSGLALLL TQGSLRASLP PQRGRAVCLD DDDTRALVAQ QPSAALAPAA
GADHLAYVIY TSGSTGQPKG VEVLRRGLRN LIPTLGQQLG MSADDVLVSA TSLSFDIAML
ELFMSLAAGA RLVLASRQVA GDGVALRALL RDSGATVFQA TPATWRLLSE AGRSAADGRL
RVAVSGGEAM SEALARELAA SADAVWNVYG PTETTIWSTG CRVDGAAAIT IGQPLANTRA
YVLDQRREPV PVGVLGELYL GGEGVARGYL GRPALTAERF VPDPFARAPG ARLYRTGDRV
RWQADGSLVF LGRVDHQVKV RGHRIELGEI ETCLARHPAV QHAVVVVRQV QGEPQLVAYF
TRRERAEADA DALAPAEARD FLRATLPEYM VPSTYVALDE LPLTGSRKVD RRALPEPEQH
GVARAHVAPR PGLESELAAL WCEVLGCEQL GADDDFFERG GHSLLAVRLL AAMKQRVGIE
LPVATLFQAS TVARLAAAVE RARTGSAPGA VLVPLASRGA GAPFFCVHLI GGDVVCYAGL
ARALDGRPFR ALRAPGLDPE SEPVASIEAL AARYIAELRT VQAQGPYLLG GWSFGGLVAL
EMARQLAAQG HAVARVALLD THPPSGDAPV DADAARRMFV ADLIGLYGDP ARVAPDDEHL
AGLDDMAAAV RHLQALGALP AELEIADLSR RLRVFQAHLA AEHGYRPVAY DGPVTLLRAA
QALPESHAGE AGDLAERWRA AGVRALAERT VPGDHFTMLA PAHAVELGRI LSACLADADA
HASAVGAGAG EGAGEGAGEG AGEGAGEGEG GASAGTSSRR KTI
//
