ID   D0MHW1_RHOM4            Unreviewed;       759 AA.
AC   D0MHW1;
DT   15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2009, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=Dipeptidyl-peptidase {ECO:0000256|RuleBase:RU366067};
DE            EC=3.4.14.- {ECO:0000256|RuleBase:RU366067};
GN   OrderedLocusNames=Rmar_1179 {ECO:0000313|EMBL:ACY48069.1};
OS   Rhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10) (Rhodothermus
OS   obamensis).
OC   Bacteria; Rhodothermota; Rhodothermia; Rhodothermales; Rhodothermaceae;
OC   Rhodothermus.
OX   NCBI_TaxID=518766 {ECO:0000313|EMBL:ACY48069.1, ECO:0000313|Proteomes:UP000002221};
RN   [1] {ECO:0000313|EMBL:ACY48069.1, ECO:0000313|Proteomes:UP000002221}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43812 / DSM 4252 / R-10
RC   {ECO:0000313|Proteomes:UP000002221};
RX   PubMed=21304669; DOI=10.4056/sigs.46736;
RA   Nolan M., Tindall B.J., Pomrenke H., Lapidus A., Copeland A.,
RA   Glavina Del Rio T., Lucas S., Chen F., Tice H., Cheng J.F., Saunders E.,
RA   Han C., Bruce D., Goodwin L., Chain P., Pitluck S., Ovchinikova G.,
RA   Pati A., Ivanova N., Mavromatis K., Chen A., Palaniappan K., Land M.,
RA   Hauser L., Chang Y.J., Jeffries C.D., Brettin T., Goker M., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Detter J.C.;
RT   "Complete genome sequence of Rhodothermus marinus type strain (R-10).";
RL   Stand. Genomic Sci. 1:283-291(2009).
CC   -!- FUNCTION: Catalyzes the removal of dipeptides from the N-terminus of
CC       oligopeptides. {ECO:0000256|RuleBase:RU366067}.
CC   -!- SIMILARITY: Belongs to the peptidase S46 family.
CC       {ECO:0000256|ARBA:ARBA00010491, ECO:0000256|RuleBase:RU366067}.
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DR   EMBL; CP001807; ACY48069.1; -; Genomic_DNA.
DR   RefSeq; WP_012843681.1; NC_013501.1.
DR   AlphaFoldDB; D0MHW1; -.
DR   STRING; 518766.Rmar_1179; -.
DR   KEGG; rmr:Rmar_1179; -.
DR   eggNOG; COG3591; Bacteria.
DR   HOGENOM; CLU_013776_0_0_10; -.
DR   OrthoDB; 9805367at2; -.
DR   Proteomes; UP000002221; Chromosome.
DR   GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0070009; F:serine-type aminopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043171; P:peptide catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR019500; Pep_S46.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   PANTHER; PTHR38469; -; 1.
DR   PANTHER; PTHR38469:SF1; PERIPLASMIC PEPTIDASE SUBFAMILY S1B; 1.
DR   Pfam; PF10459; Peptidase_S46; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW   ECO:0000256|RuleBase:RU366067}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|RuleBase:RU366067};
KW   Protease {ECO:0000256|RuleBase:RU366067};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002221};
KW   Serine protease {ECO:0000256|RuleBase:RU366067};
KW   Signal {ECO:0000256|RuleBase:RU366067}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|RuleBase:RU366067"
FT   CHAIN           23..759
FT                   /note="Dipeptidyl-peptidase"
FT                   /evidence="ECO:0000256|RuleBase:RU366067"
FT                   /id="PRO_5023145606"
FT   COILED          183..217
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   759 AA;  85474 MW;  EB6B39AF7CB0BC48 CRC64;
     MNQRAWIVAL SLTLAALSLR CAGPRETARI VEAPPLVTEA ETTATTGMRA AAPTALPGLD
     TVRAGRFDTG RLWTFEEPPL DYWEATYGFR PDSAWLARAR LGALRLVFES GRCSGAFVSP
     NGLVVTNHHC TWESLDLIDR PGEALLEEGF YADSLQGERR LPGLYAEQLL EARDVTELIV
     RGLEEIRDDV ERERLRNRRL ERLKQQLEAE ARDRDTTLHV EIVPLYYGAR YTAYTWRRYH
     DVRLVMTPEL RVGYFGGDFD NFTYPRYALD VSFLRVYGPD GRPLESPWYF PWSTEGVRRG
     QLVFAVGNPG ATQRHLTVSQ LEFERDYTLP QRLRLLRRRA EVLERYIRQQ PDSADIYGLR
     SVYFALKNTI KATEGQLRGL RDPYLLARKQ AAERALRDSM MASDSLRNYF GNVFMQLEAL
     QRSKAAAAPQ TAAFQFFGTS TLLSSHILLR ALFGYAHDLM RQRGAFPSRL EELRQEALRI
     RDWPDSVEVG YITARLEELR DYLGPQHPSV QRLLGDRSPA EVARDLVART ALKDSVAFAR
     LLREGYLNSG DASVPVIEVL GPLYFTLGQQ LDQFEARERF LNARLAALRF AVYGHSVPPD
     GTGTLRIADG RIEGYPYNGT QAPPFTTFFG MYDRFYSFRG RSGWNLPARW LTPPEAFERA
     TPLNLAASTD ISGGSSGSAL IDQDLHLVGV VFDSNIEGLA GEYVYMPDRG MRAVAVDSRG
     VLEALRDLYG ADRLVLELTT GKLIPDEATA EAALVGEVE
//