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Database: UniProt
Entry: D0MQE0_PHYIT
LinkDB: D0MQE0_PHYIT
Original site: D0MQE0_PHYIT 
ID   D0MQE0_PHYIT            Unreviewed;      1420 AA.
AC   D0MQE0;
DT   15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2009, sequence version 1.
DT   05-JUL-2017, entry version 32.
DE   SubName: Full=Ryanodine-inositol 1,4,5-triphosphate receptor Ca2 channel (RIR-CaC) family protein {ECO:0000313|EMBL:EEY57709.1};
GN   ORFNames=PITG_00274 {ECO:0000313|EMBL:EEY57709.1};
OS   Phytophthora infestans (strain T30-4) (Potato late blight fungus).
OC   Eukaryota; Stramenopiles; Oomycetes; Peronosporales; Phytophthora.
OX   NCBI_TaxID=403677 {ECO:0000313|Proteomes:UP000006643};
RN   [1] {ECO:0000313|Proteomes:UP000006643}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX   PubMed=19741609; DOI=10.1038/nature08358;
RG   The Broad Institute Genome Sequencing Platform;
RA   Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E.,
RA   Cano L.M., Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T.,
RA   Bozkurt T.O., Ah-Fong A.M., Alvarado L., Anderson V.L.,
RA   Armstrong M.R., Avrova A., Baxter L., Beynon J., Boevink P.C.,
RA   Bollmann S.R., Bos J.I., Bulone V., Cai G., Cakir C., Carrington J.C.,
RA   Chawner M., Conti L., Costanzo S., Ewan R., Fahlgren N.,
RA   Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S., Green P.J.,
RA   Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA   Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA   Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA   Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA   Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA   Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA   Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA   Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J.,
RA   Studholme D.J., Sykes S., Thines M., van de Vondervoort P.J.,
RA   Phuntumart V., Wawra S., Weide R., Win J., Young C., Zhou S., Fry W.,
RA   Meyers B.C., van West P., Ristaino J., Govers F., Birch P.R.,
RA   Whisson S.C., Judelson H.S., Nusbaum C.;
RT   "Genome sequence and analysis of the Irish potato famine pathogen
RT   Phytophthora infestans.";
RL   Nature 461:393-398(2009).
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DR   EMBL; DS028118; EEY57709.1; -; Genomic_DNA.
DR   RefSeq; XP_002908895.1; XM_002908849.1.
DR   UniGene; Pin.8805; -.
DR   STRING; 4787.PITG_00274T0; -.
DR   PRIDE; D0MQE0; -.
DR   EnsemblProtists; PITG_00274T0; PITG_00274T0; PITG_00274.
DR   GeneID; 9477025; -.
DR   KEGG; pif:PITG_00274; -.
DR   EuPathDB; FungiDB:PITG_00274; -.
DR   HOGENOM; HOG000182803; -.
DR   InParanoid; D0MQE0; -.
DR   OMA; MPSREKE; -.
DR   Proteomes; UP000006643; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR   GO; GO:0050982; P:detection of mechanical stimulus; IBA:GO_Central.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   Pfam; PF08016; PKD_channel; 2.
DR   Pfam; PF02026; RyR; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006643};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EEY57709.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    300    319       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    568    584       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    605    626       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    760    784       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      365    514       PKD_channel. {ECO:0000259|Pfam:PF08016}.
FT   DOMAIN      562    789       PKD_channel. {ECO:0000259|Pfam:PF08016}.
FT   DOMAIN     1133   1221       RyR. {ECO:0000259|Pfam:PF02026}.
FT   DOMAIN     1325   1413       RyR. {ECO:0000259|Pfam:PF02026}.
SQ   SEQUENCE   1420 AA;  158950 MW;  5ED61052B9303957 CRC64;
     MEQSKIERTT TIWDRSPQKF TYASCRKTRK TSSSSMDADD AAPVANGAPA AARAPPAPVS
     TPTLSVAKEE PAKPRNGAPS SMGAFPAASD APVPLKPKPK PTLRTPPSRL RSGSGSGSNT
     SSGRERRESG GPRPASANMG IVVGTLRRRN RVNLRTSSLS DEEANDVVSV PPRSTAMLAP
     RRSKKQPSLR NMASLVRSHL RSSKSLVSTS SESTDVDVDA DADTDKNPGL ERSNSSFAGV
     AQQLVTSRRA ARGFLSMWTK DSTETMHVYR GIHMEKKKLD LVSVASEYKE IKRRQFYQEL
     VVYVVFLTFL FSLLSWLPVQ DSFHQNDVVG ALTCREEGEC EIKTFADIYD FAGKLRDTVC
     ERQDVTAQWV RVGGVGFRQV RVKELRCRVY DGWEAPCYPF YSPEAEQKTS ILGENGTGRV
     YEWRDGLGDL SPEMYRSAID WLFFGPVPSY GSGGYAVDLC DLEDVEELQR DHYLSEHTRA
     AAFKFILLNP ITRVFTIGMH VITVDPSGHI DHFAHSSHVR VIGHEKPEQF TITDDSVEAP
     PKPKLHRRIF DALRGSMSLV REAFDVRVLL WVALVLFFIT YCIGEATEMS TMGVSTYLGS
     DMWNLFELSH LVVLAAMLSY MVHYYMASSS FALHLAELRE GRGVEELSHT SSQELLTGFQ
     QLSDLASLGS AISLLKVFKF LRMNATLNLL WRVLGMAMSD LMGFLVIFNL IFLGYSAMGS
     YAFGFALEEY STISKSYGTC FQMLAGEMDY GRLQQANPRV APLFIGTFVV LVFQILVNMF
     VAILSEYYEV AKNDETASGE DVEYDVLARI RSFVSACSPT VVVPKDHGVI RLIPWQQVRL
     ISTNLVDQEE TRQRVRKLFR GAVWRVVALL RFGMKFDRRI NFGDRKTHDG STHNGNGGSP
     GGKEDRELVS HIRLSENFDH KTIKEMIPIG ITIRLQGDSI LGDGLALKVV HHGKLSVECI
     VLGPNEAEAG SNAPGKINGG LHAFAPPRTI SSLGSFEDDS DLDDGAPRER VLELMGGEKL
     RIPRRRLAVH LCRIMFQELK NGLLRATKLW NYSKDHMVDD YHLGLLFDSV RADGRTSLRF
     DEISRMLDLF LRKDKRKAMC SQAEVRREAL QVMYRFRKCL IDMPSREKEG HNYRPKPVDT
     SKVELGHLEH LGDVLARNCH DMWALERLKQ GWQYGEERDD KKKRHPNLVP YKLLSVEEQA
     FDYRSSIETI KTIVFMNYAI TRANHQRSHS GSFHDSVSRS ASTMSDIADG MGGSNSSLLS
     GGSESTSPRA NDAAVFEELG TASHPGTPAR PVPSLLREAM SFRRNSLMGD SPYFTSYGEG
     GVEVYRPLPI DTTTVELPPR LLRLVDLLAE NAHEVWAKGR MDEGWTYGPQ RDDSTKKHPC
     LVPYVFLTDD EKEYDINIAK ETLKTLIAMK FTILDRSSKY
//
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