ID D0MRL2_PHYIT Unreviewed; 503 AA.
AC D0MRL2;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=CNNM transmembrane domain-containing protein {ECO:0000259|PROSITE:PS51846};
GN ORFNames=PITG_00746 {ECO:0000313|EMBL:EEY58131.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY58131.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS028118; EEY58131.1; -; Genomic_DNA.
DR RefSeq; XP_002909317.1; XM_002909271.1.
DR AlphaFoldDB; D0MRL2; -.
DR STRING; 403677.D0MRL2; -.
DR EnsemblProtists; PITG_00746T0; PITG_00746T0; PITG_00746.
DR GeneID; 9472547; -.
DR KEGG; pif:PITG_00746; -.
DR VEuPathDB; FungiDB:PITG_00746; -.
DR eggNOG; KOG2118; Eukaryota.
DR HOGENOM; CLU_011310_0_0_1; -.
DR InParanoid; D0MRL2; -.
DR OMA; MVIRKIP; -.
DR OrthoDB; 74670at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF97; METAL TRANSPORTER CNNM-5; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 32..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..210
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
SQ SEQUENCE 503 AA; 56273 MW; CD1EA823109D06EC CRC64;
MAIGSLSTAP TIALGATHEC EFFSPWCDPA SFYLYLAMSL LLICAAGMMA GLTMGLLSLD
MLNMRILEME GSEEEKKYAK QVLPVLTKHH LLLVTLLIVN ASANEALPIF LNKLVPEAVS
ILLSVTCVLF FGEIIPSAVF TGPNQLRIAA MLCPFVKLLM AITFPVGYPI SRVLDMWLGD
DHDPAQYKRK EIKALVTLQR ENDAARRTFV DHLRQSHQLE DTPTHSHTVT TMSAIRDKQP
LLTPHSLYED SAQGTRLHVD EVTIIHGALD LASKTVTEVM IPMEDVYMLE LDTELGPDML
ASVLASGHSR IPVYEKHKSN IVGLLLVKKL IVLDPDDRRP IRDLILRKPI LVNPKESCYA
ILNEFQKGRS HIALVTKDVD VVLRCWRSDE VIPQSVVFKG IVTIEDVIEE LIQEEIEDES
DVYVHDIVDY WQARYRKVVK GTGSAFVKKR LRLLADRARR RVKSRRSKQA AESATASSIR
VAGMPQLDAP IEVKVVTEKT PLL
//
