ID D0MTC3_PHYIT Unreviewed; 818 AA.
AC D0MTC3;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=beta-mannosidase {ECO:0000256|ARBA:ARBA00012754};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
GN ORFNames=PITG_01471 {ECO:0000313|EMBL:EEY61220.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY61220.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
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DR EMBL; DS028119; EEY61220.1; -; Genomic_DNA.
DR RefSeq; XP_002908137.1; XM_002908091.1.
DR AlphaFoldDB; D0MTC3; -.
DR STRING; 403677.D0MTC3; -.
DR EnsemblProtists; PITG_01471T0; PITG_01471T0; PITG_01471.
DR GeneID; 9468834; -.
DR KEGG; pif:PITG_01471; -.
DR VEuPathDB; FungiDB:PITG_01471; -.
DR eggNOG; KOG2230; Eukaryota.
DR HOGENOM; CLU_005015_3_1_1; -.
DR InParanoid; D0MTC3; -.
DR OMA; ILLWCEF; -.
DR OrthoDB; 2504097at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR041625; Beta-mannosidase_Ig.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF17753; Ig_mannosidase; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643}.
FT DOMAIN 146..249
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 732..788
FT /note="Beta-mannosidase Ig-fold"
FT /evidence="ECO:0000259|Pfam:PF17753"
SQ SEQUENCE 818 AA; 92468 MW; B19E4DB3FEA0DC9A CRC64;
MNAGVIGDPY YRFNEREYQW VAQETWMYET HVTLPSDVNS KPTLVFETLD GWEAAGDHGE
LLRAVQNRRG TCAPTGDQAD EYPYFVPATE NFNTWTEPTR RSFVRKAGSD FGWDWGPAFV
TSGMAGAAYI EFEEAVVKLK DLQVVQVFPR GKEDASVVDV TVRVALDSGK AAHENVTFNL
FINDKKESAI TTTISKDWKE DAAIDLLARL ENPKLWWPAG YGEPYLYDIR VDAWNSDFNS
SLSHKTGIRQ VELIQDDTTA GDVAGKTFYF KINRVPIFIK GANWIPTDSF STRTKASTVR
HLLGSVRAAN MNMVRVWGGG RYESDLFYAE CDRLGILVWQ ELMFACGMYP RDSAFLQNVL
KEVGFQISRL RKYTSIAIWG GNNENENMME QFVEAPIFPP GTPFNRDIAV VDFTKLFVDL
IHPTIVAMDS SRPFVDTSPS NGLYSVDPYV KRWGPSNGVA FGDVHFYDYN SDCQDYRMYP
RARFVSEFGF QSWPSAASLH DVSSKEDWGS FQAFWKILKF RQRHENGTTQ MLTQLQRRFH
VPFPFRNEKW LDEESVVQDM SFGFSISKRI EAYLYLTQIQ QSLCYQTAIQ TWRRGKSIEL
DNEAVQVYAV SDVNEDLQVD IVFELRRTKC GSLVKTFGLK AIAIAALVGN SMGNAESRSV
EELDIDALLD HDATSCHRRS CFLGVRCVTN SSVTGIDAAA CEDTQHFFAP FKHLNLGWGD
VVAQSVQKTK VENTVIFSVD LVATNFTALF VEVEVPGVLG YWSSNSFLMV GSETKTLNFT
VALSDNVDKL SIDAFSSLLR VNWLQKSYDN SIEDVAVQ
//
