ID D0MZY0_PHYIT Unreviewed; 1343 AA.
AC D0MZY0;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Ras-specific guanine nucleotide-releasing factor {ECO:0008006|Google:ProtNLM};
GN ORFNames=PITG_03318 {ECO:0000313|EMBL:EEY65793.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY65793.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS028121; EEY65793.1; -; Genomic_DNA.
DR RefSeq; XP_002906392.1; XM_002906346.1.
DR EnsemblProtists; PITG_03318T0; PITG_03318T0; PITG_03318.
DR GeneID; 9464716; -.
DR KEGG; pif:PITG_03318; -.
DR VEuPathDB; FungiDB:PITG_03318; -.
DR eggNOG; KOG3417; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR eggNOG; KOG4270; Eukaryota.
DR HOGENOM; CLU_005835_0_0_1; -.
DR InParanoid; D0MZY0; -.
DR OMA; VKQSIDM; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 2.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR24189; MYOTROPHIN; 1.
DR PANTHER; PTHR24189:SF50; MYOTROPHIN-RELATED; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 134..233
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 351..491
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT DOMAIN 503..572
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REPEAT 645..677
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 678..711
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 746..778
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 779..811
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1089..1279
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1343 AA; 150499 MW; 9F3B4D8C8231F7C3 CRC64;
MASGWRHKGT KAVLDPWGSP SPPPLLDETA PKISKRSRFS RRSTHAKSQA QHQAQNIELE
VEEFAEQQDR DKRRSLLASM FRTRALSRSS RSISDATEAP QALVQRDKGF RLVRHGSDPL
LNDSFYATQV QVGNFVKMGW LTKQGHMWKS WKTRFFVLFS DGTFAYYKNK GRKKIKGCMQ
LNDGVVSVQH VDIRVAGKAY VFQIEKGFYK LLCYCCSQFE AELWVAALRS VRRVSPPCYE
MDLTATEEKA GSNAVTRLLN KIFITDKEVA KNWVQFKEND HDHSYAAIHN FIVELDDSII
DRHHLELYQD PEIELLPGNE LVRLIRRHVE DRVFIPLYAE AYASLETDKV KSRRSNLEQN
VKVLKQKAQA DFGISKDLSV CNWKQAISVI NMLDSVSLPT HKFEVILSAG KTVTEEIAQY
NGELFEVTDE TLTAVFRYVV TMSSLSDLAI LRALLKYGYQ HHPACQNKAN VVTAFLDAIK
WVENFESGDE SYRFDTMALA GSRVSVSIST NDIGIQLTTD GNGRGAIVYS VRKQSQAALS
AAIVPGLSLI AINREPVIGM PFEKIIQRVR TAALPKQLTF MTEFYYYQLL SLDLEMSRYL
TCIAARRGDL DSAGWLRSST VELNTLCSWE KTRGKQVFGF IPASGKGSPL HAAVHNGQLG
MVNYLISKGA DANLCNHKGR RPLHVVKQSI DMAQIIQSLI DAGADIDAAE KHGLTPLMFM
CSRVSLEGSA TLLALGADAH RVAWSNGFSA LEFAVKSGRT ELVELCLSKG ANPNAPTLDG
STSLHLAAAL AHTDIILRLL QGGANPNIQN RCGQTPATIL LASAPNGSGD ARILCLEILT
CAGCHLDQRD LFGRQASHLA NISRDFRVVE LLRKLGSLNR GGNGVDVDIF GCSSADYTDH
IEVNKTAGFL RSLMPNDSWK IGDKDDHASR SVRSSSIDGM IRDLVTGMDV DLADVVAFVL
FLDSFSSLNE VVDRVYEHVR NGVKSHGLIR LFIMILLFRQ SESKESDDLR DRFYSLVGHA
VDVSKEKLVP LVEEFTALYK GYFSLRGAGK YALNYEMIPG MMTTLYGLES GIELVSNEPF
SRHLHRYIDA EQWAEQCTLL THAVFCKIPV HDLISPGSKR QHSVEFTSIK RWFQHISAYV
INAVLVQDTP EERAEVISFY LKLSVAAKKK MNEMQLLSDK GCREMNRLMR QTTNPSMPYI
GLYLQGFVGL NELPTFDKNG LVNASRLRRM GELSMEILHR QSVAYTLQND EDVDKLLHVS
LPYSSEESRY TRSLELEPRE ADAMPLSDRG SCALIDDDLD LESEVRESIG GDGTFGFRQW
IRKQQVVHRN RSRSSLIALY EWV
//
