ID D0N290_PHYIT Unreviewed; 630 AA.
AC D0N290;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Xaa-Pro aminopeptidase, putative {ECO:0000313|EMBL:EEY68419.1};
GN ORFNames=PITG_04875 {ECO:0000313|EMBL:EEY68419.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY68419.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; DS028123; EEY68419.1; -; Genomic_DNA.
DR RefSeq; XP_002905578.1; XM_002905532.1.
DR AlphaFoldDB; D0N290; -.
DR STRING; 403677.D0N290; -.
DR MEROPS; M24.009; -.
DR EnsemblProtists; PITG_04875T0; PITG_04875T0; PITG_04875.
DR GeneID; 9478782; -.
DR KEGG; pif:PITG_04875; -.
DR VEuPathDB; FungiDB:PITG_04875; -.
DR eggNOG; KOG2413; Eukaryota.
DR HOGENOM; CLU_011781_2_1_1; -.
DR InParanoid; D0N290; -.
DR OMA; EPGMILS; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:EEY68419.1};
KW Hydrolase {ECO:0000313|EMBL:EEY68419.1};
KW Protease {ECO:0000313|EMBL:EEY68419.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643}.
FT DOMAIN 65..163
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 337..556
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 569..630
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 630 AA; 69920 MW; 0C60DF33581F6344 CRC64;
MLAAEKLREL RVLMSRTNVR LLPLRHLLGK TEKGTAAELT GRPLQAFLVD TADAHQSEYV
GDAHKRREFL TGFTGSNGTA LVTPDQALMW TDGRYFLQAE QELSEDWTLM KSEEAGVPSI
EQWTKTNLPD DSCLAIDPYL TSVLAARNFA KVLKETKIEL VALHETENLV DLVWKDRPAV
SPSQVTFLSG EYTGRSIADK LKSLRDAVKG KGADAIILTA LDDIAWLFNI RGNDVEFNPV
VTSYAVVTPD TATLFLDAAN QHEVTQHLRS SGVECKPYSS VLSEVSALAA ANKDTKILVD
PAQCNVAVFL AIPAANRKED TSVVMAQKAI KSAVEIEGMR QAHLRDGAAL VKYFSWLEKE
MAASHEEQWD EVLVADKQEQ FRKEAKHYVS LSFDTISSVG ANGSIIHYSP KRGDCAKMST
SAMYLNDSGA QYLDGTTDVT RTLHFGQPTE YEKACFTYVL KGHIALASTV FPDKMDGVKL
DAITRAPLWK AGLDYRHGTG HGVGAFLNVH EKGVLMSFRL NPNGLKIQDG MALSNEPGYY
EDGKFGIRIE SVMVVRKAPH IKSPLNRDFC KFETLTMAPI QQKLIDASLL TPEEIKWLNA
YHKDVHDRLQ PLLQDDPDTY AYLVRETKPL
//
