ID D0N2F2_PHYIT Unreviewed; 984 AA.
AC D0N2F2;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 9 {ECO:0000256|ARBA:ARBA00042301};
GN ORFNames=PITG_04940 {ECO:0000313|EMBL:EEY68481.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY68481.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
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DR EMBL; DS028123; EEY68481.1; -; Genomic_DNA.
DR RefSeq; XP_002905640.1; XM_002905594.1.
DR AlphaFoldDB; D0N2F2; -.
DR STRING; 403677.D0N2F2; -.
DR EnsemblProtists; PITG_04940T0; PITG_04940T0; PITG_04940.
DR GeneID; 9479087; -.
DR KEGG; pif:PITG_04940; -.
DR VEuPathDB; FungiDB:PITG_04940; -.
DR eggNOG; KOG0477; Eukaryota.
DR HOGENOM; CLU_000995_7_2_1; -.
DR InParanoid; D0N2F2; -.
DR OMA; AKEVSCN; -.
DR OrthoDB; 147095at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF48; DNA HELICASE MCM9; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643}.
FT DOMAIN 467..670
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 56..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..703
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 109413 MW; E7EEE4DDBA5703A9 CRC64;
MGLDIKTVIQ EKTRWVASKL SLRKLRSTKR SRKAMETTEL QPVALAGASR GFTGSSTQCN
HFSRTPSGAQ EQWTDSSKGG RALSDGWKVC RMCQRKFSPL SMSRQYADFC SLDCKSAFML
GHGKPYDDEA TGARFERLAP EYEAAFARFL RRNYRSDLQQ LHRRLRHIST PFAGFSETPK
QSLLAYSQRV CAQRLLDFNA QLGTLLFRHP EQLLPLFHCA LAKEVSCNAG EPLEGGGLPS
IPLKARRKLK VRVENLPPVP PLRKPAISAI RSNDVKQLIQ IAGTVVRTGM IKMQEIEREY
QCCNARCGHR FLVKSDPEQG NVLEIPKVCP SDSTGDTSSG GKKPCKSTQF MPVGGADSSV
VSDHQVIKIQ EQASKLGVGS IPRSILVVLE DDLVDSVKAG DRVVVVGILM RTWKPCVRGV
RCDLETTIKA NSIRIKNATT SQVLVTEELR AEFAQFWSKH KRHPVRGRNE IVASICPKVY
GLFIVKLAVA LTVIGGVSYV DETGMKTRGE PHMLLIGDPG TGKSQFLRFT AELSPRSVLT
TGIGTTSAGL TCTAVKDGGE WMLEAGALVL ADRGVCCIDE FSSIRSNDRT SIHEAMEQQT
LSVAKAGLVC KLNARTTIFA VTNPKGRYDP TSDVSVNTSI ASPLLSRFDL ILVLLDRMNP
RWDQVVSSFI LKQAVGTSTS MKEEAERDDK ETSFEDSDHV PPRAVQEDST LWSIHKLQAY
ICHVKDKYNP QLSRGAMLIL QRYYQRQRAS DSRSAARTTI RLLESLTRLA QAHARLMCHA
EVAVMDAVVA VFVMEVSKST DNCSDMLEGG VESVLHSNFS QDPEDEYALQ EKLVLDYLVL
QELSTADDRP PESISQRKPD PVHSFPLAAE EFEEADVQGE FAGDLYVAGT LEEQIPTRKR
PASQQESGRR RRRADPPSQP FTPSSLPQRE KDDLDVMDDY RRGGQQSPHT EEQPRVPPTR
PRFDFGRWSQ QAEASQSIIS KWKK
//
