ID D0N2H4_PHYIT Unreviewed; 512 AA.
AC D0N2H4;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Aspartyl protease family A01A, putative {ECO:0000313|EMBL:EEY68503.1};
GN ORFNames=PITG_04975 {ECO:0000313|EMBL:EEY68503.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY68503.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; DS028123; EEY68503.1; -; Genomic_DNA.
DR RefSeq; XP_002905662.1; XM_002905616.1.
DR AlphaFoldDB; D0N2H4; -.
DR STRING; 403677.D0N2H4; -.
DR GeneID; 9479122; -.
DR KEGG; pif:PITG_04975; -.
DR VEuPathDB; FungiDB:PITG_04975; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_033035_0_0_1; -.
DR InParanoid; D0N2H4; -.
DR OrthoDB; 52999at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000454};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|RuleBase:RU000454, ECO:0000313|EMBL:EEY68503.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 434..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..390
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 473..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 21
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 236
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
SQ SEQUENCE 512 AA; 55947 MW; F613C4BA1D5E6F84 CRC64;
MQFFGSIGVG SPPQRFQVIF DTGSSDIWLP ESSCADCAGS RRYHAAVSRS HEPLNEPFRL
EYGSGNASGR VVREQVSLFG GDEQSLTLSR VHMGSTTKTT KSLQRFQADG IVGLGLEALA
VITKPSLLKS DPRLGLFSIY INPLPGALPP AQLIFGGVDD SLPIAHIPHA NEAQVSWHHF
PLVRYPSSRR AHGFWAIRLH RLTVGNFDSR SKSSPKKLAG SGDGIVAVSA AVAIVDSGTS
LLLLPRRAFD TTITEIQQHL RVQHSKELRV NPHAVSGYAC VDCTAEMFPA LRFSFVIEET
PAGSQSKTQT LVLKGTDYAR CDDLMCAPQL DVHALFTSKS KSKVPTPAAS AMTTNIPQGT
EHEDVVVLGV TFMRAYYVQF DSQRKTVGFA CVDSATSSAV CSGGWAPKLQ FHSAHFLDAE
ASAWRAGWVF WSRVYLGIGV LLLLVAFALL WLILVVPSSE VKKVFNWFYG PSDKSRRRQQ
QTDNRDDETA EPDSEPESPP APSRRKSVSF DV
//
