ID D0NBJ4_PHYIT Unreviewed; 815 AA.
AC D0NBJ4;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Aspartyl protease family A01A, putative {ECO:0000313|EMBL:EEY55423.1};
GN ORFNames=PITG_09387 {ECO:0000313|EMBL:EEY55423.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY55423.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; DS028131; EEY55423.1; -; Genomic_DNA.
DR RefSeq; XP_002903647.1; XM_002903601.1.
DR AlphaFoldDB; D0NBJ4; -.
DR SMR; D0NBJ4; -.
DR STRING; 403677.D0NBJ4; -.
DR GeneID; 9474942; -.
DR KEGG; pif:PITG_09387; -.
DR VEuPathDB; FungiDB:PITG_09387; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_013253_3_4_1; -.
DR InParanoid; D0NBJ4; -.
DR OrthoDB; 615305at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.40.70.10; Acid Proteases; 3.
DR Gene3D; 3.30.70.141; Nucleoside diphosphate kinase-like domain; 1.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR036850; NDK-like_dom_sf.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR Pfam; PF00026; Asp; 2.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF54919; Nucleoside diphosphate kinase, NDK; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454, ECO:0000313|EMBL:EEY55423.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..815
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003012482"
FT DOMAIN 83..370
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
SQ SEQUENCE 815 AA; 90037 MW; 86DEF3051BF45E38 CRC64;
MMLRCSVLCS LLLALSSAAV MRVPMIKRSD DEFVSSLLHD VHAMQRPVVW SPDASPINNQ
NEGQSTVEGS ASVVIRDFQN AQYYGEISIG TPPQPFAVIF DTGSSNLWVP DKKFGSHNVY
DHDKSSTYKP NGTAFDIMYG SGPVSGFLSQ DKLELGGLTV PDQYFAEVNV TKGLGPAYYL
GKFDGLFGLA FDTISVDHLK TPFHRMVQEG LLDEPVFAFY LGDQKDGELT FGGVDKAHYK
GEIEYVDVTS ATYWSVKLGH CGLWHLAHRW TEDQVAKLAA LVGAHKFIMG EYLISCTAAA
PDISFVLNGK TYTLTKEEYT LKSGPICLFA FMGIDIPAPA GPLWILGDVF MRKHYTVFDW
GTDSRKPRAA QLSVLALQAD ALEHDEAVRQ ELKRSGFVVR QQALVHLSID AARQFVLEVC
NPHSAMYRPP PLEENEDEKL QATSEQHDAV SRASNVKANL EMTEEDNEIL EHAIHALASG
PALILGVEKP NAVAELLQLV GPGDPSAWTE GASSCLRARF AKDAPRKLGL RCSTHEKTAT
HELAFLLAHS GNKTHAYGQG HAAVTPPNGR SGGRTSAMGL DQLLNFLFPD HLQHPTSAGR
LFVFGLYGPL DKCSRLRSGE KGLHVVTDRE LTTMSARMER EDILAVYGIC SLSQEEEEEV
VRQVDNLLKR FPQYTPRDIE TLFAPLPRDS DGHMSFHDMQ QAVLKERLRR VVCMKERLHP
ALAEPVRNRF SRTLTRLTAT KTAGLINGAP SSFFLRDIGA TNVENVSLVS RLLSTRSSQI
CQMEDGNSPA LTQNVRLARP DKAQGFTERE PWNPT
//
