ID D0NMW7_PHYIT Unreviewed; 3703 AA.
AC D0NMW7;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Vacuolar protein 8 {ECO:0000256|ARBA:ARBA00026209};
GN ORFNames=PITG_13834 {ECO:0000313|EMBL:EEY61874.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY61874.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004635}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004592}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004592}.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS028147; EEY61874.1; -; Genomic_DNA.
DR RefSeq; XP_002899514.1; XM_002899468.1.
DR EnsemblProtists; PITG_13834T0; PITG_13834T0; PITG_13834.
DR GeneID; 9461463; -.
DR KEGG; pif:PITG_13834; -.
DR VEuPathDB; FungiDB:PITG_13834; -.
DR eggNOG; KOG0166; Eukaryota.
DR eggNOG; KOG0167; Eukaryota.
DR eggNOG; KOG4224; Eukaryota.
DR HOGENOM; CLU_000077_0_0_1; -.
DR InParanoid; D0NMW7; -.
DR OMA; IAFALCN; -.
DR OrthoDB; 49008at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IEA:InterPro.
DR GO; GO:0071562; P:nucleus-vacuole junction assembly; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 19.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR004155; PBS_lyase_HEAT.
DR InterPro; IPR045156; Vac8.
DR PANTHER; PTHR47249; VACUOLAR PROTEIN 8; 1.
DR PANTHER; PTHR47249:SF1; VACUOLAR PROTEIN 8; 1.
DR Pfam; PF00514; Arm; 10.
DR SMART; SM00185; ARM; 75.
DR SMART; SM00567; EZ_HEAT; 7.
DR SUPFAM; SSF48371; ARM repeat; 12.
DR PROSITE; PS50176; ARM_REPEAT; 27.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT REPEAT 132..174
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 377..421
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 461..503
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 502..544
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 543..585
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 584..626
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 666..710
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 709..751
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 791..833
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 832..874
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 873..915
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 1043..1077
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 1292..1334
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 1333..1375
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 1710..1752
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 2215..2257
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 2422..2464
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 2463..2506
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 2505..2548
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 2547..2589
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 2712..2755
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 2878..2906
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 3000..3042
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 3041..3069
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 3131..3175
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 3215..3257
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 3615..3647
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 3703 AA; 398080 MW; 285E9310A5352E48 CRC64;
MSKVLEQLIA RGRRERKPTE QRDVAFSLAE ISTNAELHEK MVSKGVVKAL LTLILQSSDP
EALRLACLCM ANVASCPASR VRIVEDGVLP PLVKFFKDDD NENDAVAKQY VAMTIGNLAA
EPENHEEIVQ LGTIEPLVKL LDPEIVHSGV YCAFALANLS VNNEYRPQIV EEGAIPRLIA
LACCKELTAQ RQSLACLRGI CISPGNRVVV VKEGMLDPLV LMARSDEPDI QREVAAAFCA
LSATPENKVE ISDRALLTII SLSLSGDPAV EEYACSTIAN LTELHELHDK LLRENGLASI
MALAVTRDLN TRSEACRCLA NLTANEEVQP ALMKEGVLQP LATALVLNHH VCQRYAALAL
ANLSTTASYQ VQIVGLGTIT PLIALAQAFD RELEARRYAV LAIANLAAMK ANHPALVEAG
CLLSLFSLAS TADALSQYYV AFALANFASN EQNHTRMVEE GGLQPIITLA SSEDTDVHHR
AVAALRGLGV SEANKVKILQ EGGLEPLVLL LQSDDLEILR ETCAALCNLS VSEETKYEIA
KSGAVAPLIA HSQSEDMELA RQSCATLANL AEVEENQEKI CADGGVPPLI AMMRSQFVEV
QREAGRALGN LSAFRLNHED MIEHGGHQLL ISYLLSPDMA SQRVGALGIC NLATNPAIRE
LLMESGAMEP LMSLARSEDV ELEIQRFAIL AIANLATCVE NHRAIVEEGS LPLLISLSSA
PDEEVRQYAA FALVKVALNA DLRKQITEEG GLEPVLFLAR TQSSDLQADV LPAICTLSFA
DANKSDICKC GGLPPILGAL KHADVGVQRQ ALCAVANLAE DVENQSHLVA NGAIPPVVEA
LQHGGIIAQR EAARALGNLS ANCDFAEVIL RQGAAPPLIQ LLGSEVVDCQ RMAAMALCNL
GTNVNNQPKL LAQGVLPPIL ARIEEALDPR SLADNDVIRY CLLVLANLAV SPSTHEELLD
KALTFLAGYA KHRDVKCRQF AIFAVGNLCS NPKNIERIVA TNCLQPIISF AFPGGANVQF
QAIAGLRGLS VNQAVRQQVV RLGALEPLIL AASSESIEVQ REVAATLSNL SLSEENKITM
ARGGCLPALI ALASSRDSYR ERQAVCALAN LAEMIEGHTH KKMLEEGVLT PLYALATGAD
LEVKRQVSRC LALFAAKPSS QATLLRSSAL RYISAFAQET EDAVCRRFGT LAIGNLAVDH
KNHRDLFDQG AVTALMTVDK ATDLETRRAL AFALNNLAAN ESNSAQISKL GGLRTVIALL
HDADEDTHLQ ACFALRRMVV EAKSRTQAVS FGALLPLFKL ALSENIEVQR EVCAALRNLS
LSEDNKVVIV LNGGLAPLLT LVHSADGEVA HQACGVLANL AEVVENQGRM VKDGVLQHIK
FVLRAKSVDV QREALRAIAN MSAEYAYTAE IVSSGGLAPL MAALNAPDFL SQRYAAMGIA
NLSTNVDNIT KIVQDALVPT LVALADGSLN GDLDTQRYAV FTLTNIASVR ATQSVLVDAG
VLPLFADLLQ HADMALRNGA AFGIANFTAF SENHTVLLEL GEVFLEALLR LLESQDSKCQ
YRAVCALRGL CVNELARREL VRRGVLRPLL ALTKSEDMDV QQEVLACLCN LSLSGCVGAY
PEVFIAACEM QALVAFLCSA DATYRLFGAV TLGNIAAKAE YQDELVAAGA VSPLVEVANS
VDLETHRCIA FALCNLAANP DRRQMVEAMG GLPPIIQLAC SVDVNDQKTA IAALRGLSNR
PETRLHIVSE GGLEPLVLGA RSSDVQLHRE VTMTTYNLSL AEKNKLAIAS SPLTGSLITL
MLSNDEDTAA FASASVANIA ENCDTHSAIA EQRGLRFFLE FETRGAPARV AREAVKCVAN
LSSNYALHDL LLADGCHEFL VRAIEHTDSK TRLFGVVGLG NLVSNPQNHA RVLREKVVTP
LIGLSVDVDH PEPRRFALLA LGCIFTNEAS HEAFVGNGVL PALIAALDAV NDMETRFYAA
FALGKISTNE SLHELIGQLS NSGGPLIKLA LDAEEAKHPS AQCHAVSVLR RITNLDVNRV
SMVAQHREDL AAALLTCARH TELLENQREA AACLCNLGLA QCNKLIFATA PALFQQLFAL
CSSPDVEVAR NACGAAANVA ENARTHEYMI DTHAVHVGVK AMRSRHLPVY REASRLVANL
MSTPEFHAVL LNEEGLAAVA RVAKIEDHEC QYNTALALHK LTSNCDTHRA LLGCGSVQTL
HMLLGSPGLD VQRQAAAALK TLTANKDNKP TLAEDGGTML ALISLLRSAD ATLKTMGAAG
VRHLSLYAPV KTQFVHEGGL PPLFSCCAVE DDDVRLQCAG AMATLSENVL NQVQMVREGA
LPALLELTKA SYNAEIARHI SRTFANVSSN AENHLGVFTL QEFRAIFTLA QSTEEFCGRD
AAMCLGNLAV TSHNQFQISE LGGLVPLSEL LKSEFASTRQ YAARAFYRLS AHSENQHRIV
DAGALPALVA RLNEIGDQEI QRCAAMAICN LSSNASNEQK IMKAGAMRAL VALLRSPSVE
CSKYAAMALC NLTANPANQL HLVVQDDGLD PLVDLAGSSD TECSRYASMT LANVSAHRQN
RLVVVERHAL QPLRALCLSP NLECQRSAAL ALYNVSCAQA NQLKLVEAGI ESALVRLAGA
KDGDCKRYAT MTLCNLAANS ETRSAAARGG GLQALLLAAK DAADPTVRRY ACIALCNLAC
APLLQVQVLV HGGLAPILAL TEDEDDVESQ RFAIMALSNL AANENNHDHM INRGVLKVAL
RLGQSKDEDI RLYAAFALAN FAGNTAQCAA IGDEGGIAAL IMLSHAEDSN SHTLAVSALR
RLCQFSAQNR GRIVRGGGLP PLAMAGMSEE LETQREVAAT YCNLSLSDEY KVEIVEQGAL
RPLIKLAQSS DLEVARQACG ALANLAEHLD THSHFVAERS GDFLIALMKH RNEEIHREAS
RTIANLLSSF EHHTDMIADG LPGLVHLGLS LDPECQYNAA LALRKLAPNF ASHRGLVYEG
GLKTLFFLLH AKELNTRRQS VLALRDLAAN SEFRRKYVEE GGLNALVTFL RDVDASLQAP
AVAALRHLTS SASHPEIKQQ VVDEGALRPV LRCLNTNPGA KGLRDLQCQC VGLIANVSEH
PTNQQKIVAE GLTSALVALA KVAQDSAEIL QDVSRALANL CSNEENHQAV YKQGALLSLI
QLTESADDVT QRYAAMGLRF LSANPTIRVH IVQESLLQPF IRLAQSPLLD YQRTAAAAFS
SFSLNEENKL KLVRDGGLAH ILRCCAYDDL EVKRDCVFAL ANVARLTGAP TGSHDDARVQ
RDCARVFASL SVTNSVKSEL VRQGALPSLF RLTRSLDVAT QRFATLAICN VASSGDDKAF
IVEQGAVRPL THLIRFPDAQ IQRYAALALA ALALGGMGNN KLRLIEEGAV PPLIDLLRYP
SADVQLCGCL ALNALTLGKQ SVTKVSVMQS GGLLPLLALL ASADEECVRC ALYCLGSLAE
SKDVLQKLVE LGTLTHVIAL TKCIDTETLR NCGYILALVV EQQTDYHDDL YREGGLDAAI
ALACVEDMEC QEYATFTLAH LASNREYQVR LVERGALRPL IAMMSVHAEP RHYAGLALLK
LADNYENHLR IAEEGGIQAL LRIARARSTD EELQYKASLS LGQLASNATR SLPNHTTLKS
GDALIGTSVN KMAQLTQAVA AKKAAKDKTM QYLDDKLARE AVK
//
