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Database: UniProt
Entry: D0NPN2_PHYIT
LinkDB: D0NPN2_PHYIT
Original site: D0NPN2_PHYIT 
ID   D0NPN2_PHYIT            Unreviewed;       859 AA.
AC   D0NPN2;
DT   15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2009, sequence version 1.
DT   05-JUL-2017, entry version 34.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=PITG_14362 {ECO:0000313|EMBL:EEY62594.1};
OS   Phytophthora infestans (strain T30-4) (Potato late blight fungus).
OC   Eukaryota; Stramenopiles; Oomycetes; Peronosporales; Phytophthora.
OX   NCBI_TaxID=403677 {ECO:0000313|Proteomes:UP000006643};
RN   [1] {ECO:0000313|Proteomes:UP000006643}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX   PubMed=19741609; DOI=10.1038/nature08358;
RG   The Broad Institute Genome Sequencing Platform;
RA   Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E.,
RA   Cano L.M., Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T.,
RA   Bozkurt T.O., Ah-Fong A.M., Alvarado L., Anderson V.L.,
RA   Armstrong M.R., Avrova A., Baxter L., Beynon J., Boevink P.C.,
RA   Bollmann S.R., Bos J.I., Bulone V., Cai G., Cakir C., Carrington J.C.,
RA   Chawner M., Conti L., Costanzo S., Ewan R., Fahlgren N.,
RA   Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S., Green P.J.,
RA   Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA   Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA   Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA   Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA   Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA   Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA   Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA   Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J.,
RA   Studholme D.J., Sykes S., Thines M., van de Vondervoort P.J.,
RA   Phuntumart V., Wawra S., Weide R., Win J., Young C., Zhou S., Fry W.,
RA   Meyers B.C., van West P., Ristaino J., Govers F., Birch P.R.,
RA   Whisson S.C., Judelson H.S., Nusbaum C.;
RT   "Genome sequence and analysis of the Irish potato famine pathogen
RT   Phytophthora infestans.";
RL   Nature 461:393-398(2009).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; DS028151; EEY62594.1; -; Genomic_DNA.
DR   RefSeq; XP_002898836.1; XM_002898790.1.
DR   UniGene; Pin.5235; -.
DR   STRING; 4787.PITG_14362T0; -.
DR   PRIDE; D0NPN2; -.
DR   EnsemblProtists; PITG_14362T0; PITG_14362T0; PITG_14362.
DR   GeneID; 9479688; -.
DR   KEGG; pif:PITG_14362; -.
DR   EuPathDB; FungiDB:PITG_14362; -.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; D0NPN2; -.
DR   KO; K02154; -.
DR   OMA; WTAYDAH; -.
DR   Proteomes; UP000006643; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006643};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    417    441       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    462    480       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    560    578       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    590    613       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    672    691       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    793    818       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       99    133       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   859 AA;  97689 MW;  C947D351C244B983 CRC64;
     MKWLRSAEME YISLIVNEDA AHDCVQKLGD LGVLEFTDLN PELTPFQRRY VNYVKRCDEM
     ERKLRYFEVE LAKFSISPKP AGSIDQFLAG SADIRYGSQD TAARALDTLE RLLEDKEQEL
     LQLNSMHEKL TREYNERKEL QEIISRAGEF FEIEIPEVQA RRTSRTTSRS GYSFVETSSG
     VPGGEESSSL RFHNVTGVVP ADERLKFERM IFRTTRGNCF TRFLPIEEPL VDPTNGQPVT
     KHAFVIFFQS NFIETKLRKI CDAFHARLYS LPPMDDRAAI AHLIQSNAGE LNQSSHILRR
     NRESCVLLCR DLAETLESWK WSVLQEKATY HALNMFRADV SEALPSVRRA VTRAHAAADD
     KSMPSLVDTV AKPWPVPPTF FETNKFTDAF QSFVETYGCP RYREVNPSVF TAVTFPFLFG
     VMYGDIGHGF CVLLFGLYLI LTERKLEQPG SMGEMAVSIY GGRYMLFMMG AFAMYAGLIY
     NDFFSLPLNL FGSKFAYPDC LESHDREAKC VAQYLIDGKM TYVNATDVSA GDNVYAMGLD
     PVWKTSSNEL LFFNSFKMKI SVIFGIIQMT FGILLKGWNN LYFRDYSTFF FEFVPQIVFA
     VSLFCYMIVL IVMKWSINWT ERMKHEVCPY NYAGEHTGCR PPSLVNTLIN IALAPGSVVD
     PLYEGQLETQ QTLLMMAFLS VPAMLLVKPI YLKIQNDRTA PPVNHHVDFD DEAEERLVSH
     HHGNAGGGHG GHGGEFEFGE VVIHQGIETI EFVLGMVSNT ASYLRLWALS LAHSELATVF
     WEKTMLSTIN SDSFIAIFIG FGVFAATTFG VILAMDVLEC FLHALRLHWV EFQNKFYKAD
     GHKFHPFSFK QTIKDSQQV
//
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