ID D0R1Q0_LACJF Unreviewed; 608 AA.
AC D0R1Q0;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:CAX66115.1};
GN OrderedLocusNames=FI9785_228 {ECO:0000313|EMBL:CAX66115.1};
OS Lactobacillus johnsonii (strain FI9785).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=633699 {ECO:0000313|EMBL:CAX66115.1, ECO:0000313|Proteomes:UP000002627};
RN [1] {ECO:0000313|EMBL:CAX66115.1, ECO:0000313|Proteomes:UP000002627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FI9785 {ECO:0000313|EMBL:CAX66115.1,
RC ECO:0000313|Proteomes:UP000002627};
RX PubMed=19767436; DOI=10.1128/JB.01182-09;
RA Wegmann U., Overweg K., Horn N., Goesmann A., Narbad A., Gasson M.J.,
RA Shearman C.;
RT "Complete genome sequence of Lactobacillus johnsonii FI9785, a competitive
RT exclusion agent against pathogens in poultry.";
RL J. Bacteriol. 191:7142-7143(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FN298497; CAX66115.1; -; Genomic_DNA.
DR RefSeq; WP_012845536.1; NC_013504.1.
DR AlphaFoldDB; D0R1Q0; -.
DR KEGG; ljf:FI9785_228; -.
DR HOGENOM; CLU_030184_0_0_9; -.
DR Proteomes; UP000002627; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR43562:SF1; NA(+)_H(+) ANTIPORTER YJBQ-RELATED; 1.
DR PANTHER; PTHR43562; NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002627};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 394..493
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 525..606
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 608 AA; 67856 MW; 35A7BE12848790CD CRC64;
MDLSIFIVSL AALVIPIVMA RFRINAIPTA VAEIVTGIIL GKSLLDTIKI TSSVSLLSNL
GVILLMFLSG MEINFDLFKK KDLPESKQSK INPARIAIIA FTAITITAFA LAYILKLIGL
FNDVMLAMII FMTVALGVVI ATLKEKEILS RPIGQTILLT AVLGEVIPLL LLTIYASING
GNAGRLWLIV LLFLAAIILL KRFKQPYQWF NKISKATTQL DIRLAFFLIF TLVTVAERVG
AENILGAFLA GMVMKLLEPS EATMDKLTSI GYGFFIPIFF ITTGVKLDLK SLLANPNALM
LIPVLVLFLL LAKLPIFLVY TRNFNKRNSL AGTFLIMTTI TIVLPTLEVA RKLNAITETQ
SDAFILAAVV VCILGPILFN SLFRLTKEDK IKQRVVMMGT NVMTVPVAQE LHDNWYDVLL
VTHKKENYDT YKSKVANLKL INSLEEACLE KAGVFDCDIL VAGFIEDDLN RKIARLAKEH
GVQRVIASQE RPKPETIKKL VSEKIEIYNI FNVQTSVLRA LIESPSILRI LTDTRNGLFE
VTVRNHKYAG QKLMNLDFIE QMTVSRIWRN GKWLVPHGNT IIEVGDHLIF TAKGEDAERI
REELGRRN
//
