ID D0R5P2_LACJF Unreviewed; 689 AA.
AC D0R5P2;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Sulfatase N-terminal domain-containing protein {ECO:0000259|Pfam:PF00884};
GN OrderedLocusNames=FI9785_1550 {ECO:0000313|EMBL:CAX67405.1};
OS Lactobacillus johnsonii (strain FI9785).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=633699 {ECO:0000313|EMBL:CAX67405.1, ECO:0000313|Proteomes:UP000002627};
RN [1] {ECO:0000313|EMBL:CAX67405.1, ECO:0000313|Proteomes:UP000002627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FI9785 {ECO:0000313|EMBL:CAX67405.1,
RC ECO:0000313|Proteomes:UP000002627};
RX PubMed=19767436; DOI=10.1128/JB.01182-09;
RA Wegmann U., Overweg K., Horn N., Goesmann A., Narbad A., Gasson M.J.,
RA Shearman C.;
RT "Complete genome sequence of Lactobacillus johnsonii FI9785, a competitive
RT exclusion agent against pathogens in poultry.";
RL J. Bacteriol. 191:7142-7143(2009).
CC -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004936}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LTA synthase family.
CC {ECO:0000256|ARBA:ARBA00009983}.
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DR EMBL; FN298497; CAX67405.1; -; Genomic_DNA.
DR RefSeq; WP_012846605.1; NC_013504.1.
DR AlphaFoldDB; D0R5P2; -.
DR KEGG; ljf:FI9785_1550; -.
DR HOGENOM; CLU_021310_0_0_9; -.
DR OMA; VSNHRPF; -.
DR Proteomes; UP000002627; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:InterPro.
DR CDD; cd16015; LTA_synthase; 1.
DR Gene3D; 3.30.1120.170; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR012160; LtaS-like.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR PIRSF; PIRSF005091; Mmb_sulf_HI1246; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Manganese {ECO:0000256|PIRSR:PIRSR005091-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR005091-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002627};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 48..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 253..546
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT ACT_SITE 305
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-1"
FT BINDING 261
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 305
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 422
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-2"
FT BINDING 481
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 482
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
SQ SEQUENCE 689 AA; 78294 MW; 1779C691F4B1882E CRC64;
MGRLKASYNW LTKTKLGFFT VVVVFFWIKT YLTYITKFNL GVVGSMQNFL LLINPLPTAI
LLIGIGLFFK GRKSYWIMVI IDFLLSLWLF SNILYYREFS DFLSTSIIKT SGSTSDNLGK
SIAGITKGTD FLVFLDVVII VLLIAFKVFK IDVRRLKLKV SFLIEGLAVV LIGTNLTMAQ
KDRSGLLTRT FDNNYIVKYL GLNAFAVYDG VKTAQNNAIM AKANHSDLKT VQSYIKKNYI
APNPEYYGVA KNKNVLVIHL ESFQQFLIDY KWHGKEVTPN LNKLYHANDT ISFDNFFNQV
GQGKTSDAEM MLENSIFGLQ SGSAMSSYGT SNTFESAPAI LGQKAGYTSA VMHGGAGSFW
NRDNAYKSFG YNYFMPLSYY QNKKGYYLGY GIKDKLFFDQ SIKYMEHLPQ PFYLKMITVT
NHYPYDLDKK NQSIDKTDTG DKTVDGYVQT AHYLDQAIGE LMSYLKKSGL EKNTLIMLYG
DHYGISGNHH KASAQLLDKD SFNNFDNLQF QRVPLMFHMP GLKGGINHTY GGEIDVRPTL
FNLLGINDQN MIQFGHSLLA KNAPQIVAQR NGDFITPKYS KVEGSYYYTQ SGKRITHPSK
EVKAQLASIS NTVTTELSLS DRVITGNLLR FYKPDGFEYV KRKNYSYKKS DSLKRLKKAE
KKSKNSVWYQ NGKKTTQSYF KTDAPELKK
//