ID D0V8B1_9VEST Unreviewed; 316 AA.
AC D0V8B1;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Homeobox protein 1 {ECO:0000313|EMBL:ACX84671.1};
OS Steromphala varia.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Vetigastropoda; Trochida; Trochoidea; Trochidae; Cantharidinae;
OC Steromphala.
OX NCBI_TaxID=2072698 {ECO:0000313|EMBL:ACX84671.1};
RN [1] {ECO:0000313|EMBL:ACX84671.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19949812; DOI=10.1007/s00427-009-0308-6;
RA Samadi L., Steiner G.;
RT "Involvement of Hox genes in shell morphogenesis in the encapsulated
RT development of a top shell gastropod (Gibbula varia L.).";
RL Dev. Genes Evol. 219:523-530(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; GU056183; ACX84671.1; -; mRNA.
DR AlphaFoldDB; D0V8B1; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946; HOMEOBOX PROTEIN ROUGH-RELATED; 1.
DR PANTHER; PTHR45946:SF4; HOMEOBOX PROTEIN ROUGH-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 190..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..113
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 55..114
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 316 AA; 37026 MW; 72A114EAA8EBA238 CRC64;
MLTDHPPSAA APRTPKHHTI ATYKWMQVKR TPIPKPEMPK YPCPGGDFKY AGGINSTGRT
NFWNKQAFEF EKEFHFNKYF TRARRIEIAA ALGLNETQVK IWFQNSRMKQ KKRMSEIQFE
KGNENTCQLG LDGINVPTLR LCHDARLSVC FVTTTCFFKM AIVPTEVTLW TFCFDSKEQC
LCLICDFVCF PLTVFIVQIA CLLNSVTTCL LLNPQRRDDS KTFQTFPLDK QSSYINNDIN
SFRMSCLIST FVIMFIAPIF ILTDQFQTNR DFVFRAIDQK TLCFYIVRTW DVFFEWCEYF
RFLKMIQWPS IVESIE
//
