ID D0VDD2_HELPX Unreviewed; 276 AA.
AC D0VDD2;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
OS Helicobacter pylori (Campylobacter pylori).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=210 {ECO:0000313|EMBL:ACY08078.1};
RN [1] {ECO:0000313|EMBL:ACY08078.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Shi236 {ECO:0000313|EMBL:ACY08078.1}, Shi314
RC {ECO:0000313|EMBL:ACY08079.1}, Shi33 {ECO:0000313|EMBL:ACY08081.1},
RC and Shi384 {ECO:0000313|EMBL:ACY08082.1};
RX PubMed=21124785; DOI=10.1371/journal.pone.0015076;
RA Kersulyte D., Kalia A., Gilman R.H., Mendez M., Herrera P., Cabrera L.,
RA Velapatino B., Balqui J., Paredes Puente de la Vega F.,
RA Rodriguez Ulloa C.A., Cok J., Hooper C.C., Dailide G., Tamma S., Berg D.E.;
RT "Helicobacter pylori from Peruvian amerindians: traces of human migrations
RT in strains from remote Amazon, and genome sequence of an Amerind strain.";
RL PLoS ONE 5:E15076-E15076(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
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DR EMBL; GU064430; ACY08078.1; -; Genomic_DNA.
DR EMBL; GU064431; ACY08079.1; -; Genomic_DNA.
DR EMBL; GU064433; ACY08081.1; -; Genomic_DNA.
DR EMBL; GU064434; ACY08082.1; -; Genomic_DNA.
DR AlphaFoldDB; D0VDD2; -.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-EC.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR43628; ACTIVATOR OF C KINASE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR43628:SF1; CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED; 1.
DR Pfam; PF08238; Sel1; 3.
DR SMART; SM00671; SEL1; 3.
DR SUPFAM; SSF81901; HCP-like; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..276
FT /note="beta-lactamase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007650113"
SQ SEQUENCE 276 AA; 31539 MW; BFD937EFBDDF2D86 CRC64;
MFKDFYRTTF SFLKPLLLLL CLLLPFSLHA DLDDCRITCV WDQYAKEFKT NFCKFGLNNL
NYGQYKQAFQ FFRWAQEHGI GLGSVYLAKM YLEGKGVKRD YKKAQLYAKN AIKGYGSGLL
GGALILGRMQ AEGLGMKKDL KQALNTYRQV LRVFSNKGIN FHNNFRLPDL TEMTGMLIGA
RFIDLSSLNA NPIKFEKQFA NMVEFVSGIK NEPIVPYDVA EISSNIILLK QQMGEILYRI
GIAYQEGLGT KKKKKKAKKF LQKSAEFGYE KAMEAL
//