ID D0W159_NEICI Unreviewed; 810 AA.
AC D0W159;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=FtsK/SpoIIIE family protein {ECO:0000313|EMBL:EEZ72447.1};
GN ORFNames=NEICINOT_03378 {ECO:0000313|EMBL:EEZ72447.1};
OS Neisseria cinerea ATCC 14685.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=546262 {ECO:0000313|EMBL:EEZ72447.1, ECO:0000313|Proteomes:UP000003294};
RN [1] {ECO:0000313|EMBL:EEZ72447.1, ECO:0000313|Proteomes:UP000003294}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14685 {ECO:0000313|EMBL:EEZ72447.1,
RC ECO:0000313|Proteomes:UP000003294};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Translocation stops specifically at Xer-dif sites, where FtsK
CC interacts with the Xer recombinase, allowing activation of chromosome
CC unlinking by recombination. FtsK orienting polar sequences (KOPS) guide
CC the direction of DNA translocation. FtsK can remove proteins from DNA
CC as it translocates, but translocation stops specifically at XerCD-dif
CC site, thereby preventing removal of XerC and XerD from dif.
CC {ECO:0000256|ARBA:ARBA00024784}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEZ72447.1}.
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DR EMBL; ACDY02000002; EEZ72447.1; -; Genomic_DNA.
DR RefSeq; WP_003675178.1; NZ_ACDY02000002.1.
DR AlphaFoldDB; D0W159; -.
DR STRING; 546262.NEICINOT_03378; -.
DR eggNOG; COG1674; Bacteria.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000003294; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 459..668
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 476..483
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 810 AA; 88013 MW; 5A50FB5091E2B9C0 CRC64;
MTEKSNKKIT KGRAANQSQN SSRKKDNGAR GNKVSEQLKA AKELQKTEAK KARPEHVVNL
IADALWLMGL AATLYMTISL ISFDMGDPSW SRSSPVVEDA TNWGGLFGAY IADVGYYLFG
WSFWWWIVAA CVMLYKNFRL HAKPALPGSY NHKIAVAALF ILTVFSPVLE YFVLGGKYSE
SLPVGAGGMV GIRVGAIFAW LLGKSGSLLI ILVVLLLSVS LLVQVSWLEV LNGTSRTIQN
CLAVSGRKIS SLGKRRPNTK KDSVDTLNTR RMVKEAKNIT AKPVVSLEGS TSNRKSVAVS
VAPPPKIQAS LFEDNEVQSN GEYHKPALNL LRLPDNEPVS INPAELERTA ELIESKLAEF
GIGVQVVSAT SGPVITRYEI EPAQGIKGSQ IVALSKDLAR SMSLQSVRIV ETIAGKNTMG
IELPNDKRQD VMLSEILSSP VFTEAKSKLT VALGKDIAGT PVVGDLAKMP HLLVAGMTGS
GKSVGVNGMI MSMLFKATPE EVRFIMIDPK MLELSIYDGI PHLLCPVVTD MREAGQALNW
CVAEMEKRYR LLSHAGVRNL EGFNQKVEAA KAAGKPLLNP FSLSPDNPEP LEKLPLIVVV
IDELADLMMT ERKSVEQQIA RLAQKARAAG IHMIVATQRP SVDVVTGLIK ANIPTRMAFT
VQSKIDSRTI LDQMGADELL KYGDSLFLQP GSAEPTRLQG AFVSDDEVHQ VVNYVKSQAP
ADYVEGLLSG EAALETTNIV NPNAGSDELF DQAVAYILES KKTSISSLQR QLRIGYNRAA
NLMEALENAC VVSPADMNGS RKILAHKDHL
//
