ID   D0W994_NEILA            Unreviewed;       494 AA.
AC   D0W994;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=TldD/PmbA family protein {ECO:0000313|EMBL:EEZ75850.1};
GN   ORFNames=NEILACOT_04102 {ECO:0000313|EMBL:EEZ75850.1};
OS   Neisseria lactamica ATCC 23970.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=546265 {ECO:0000313|EMBL:EEZ75850.1, ECO:0000313|Proteomes:UP000003843};
RN   [1] {ECO:0000313|EMBL:EEZ75850.1, ECO:0000313|Proteomes:UP000003843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23970 {ECO:0000313|EMBL:EEZ75850.1,
RC   ECO:0000313|Proteomes:UP000003843};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA   Mardis E.R., Wilson R.K.;
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase U62 family.
CC       {ECO:0000256|ARBA:ARBA00005836}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEZ75850.1}.
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DR   EMBL; ACEQ02000011; EEZ75850.1; -; Genomic_DNA.
DR   AlphaFoldDB; D0W994; -.
DR   Proteomes; UP000003843; Unassembled WGS sequence.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR   InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR   InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR   InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR   InterPro; IPR025502; TldD.
DR   InterPro; IPR035068; TldD/PmbA_N.
DR   InterPro; IPR036059; TldD/PmbA_sf.
DR   PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR   PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR   Pfam; PF01523; PmbA_TldD_1st; 1.
DR   Pfam; PF19290; PmbA_TldD_2nd; 1.
DR   Pfam; PF19289; PmbA_TldD_3rd; 1.
DR   PIRSF; PIRSF004919; TldD; 1.
DR   SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670}.
FT   DOMAIN          52..114
FT                   /note="Metalloprotease TldD/E N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01523"
FT   DOMAIN          141..249
FT                   /note="Metalloprotease TldD/E central"
FT                   /evidence="ECO:0000259|Pfam:PF19290"
FT   DOMAIN          257..484
FT                   /note="Metalloprotease TldD/E C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19289"
SQ   SEQUENCE   494 AA;  52382 MW;  C223B8BBE2AE4ACB CRC64;
     MPYNQAPDFL CADTMHPTYS AVRERLLEAN RLSPELLAKS LCIIGAHHVD YADIYCQRTA
     YESWHLEEGI VKSGSFQIDQ GMGVRAVSGD KTAFAYADSL CIDSINRSAR AVRAIGAAGG
     KVSAKMPSET RGKPVCSASD PIAGLDSAAK VALLNKVEAI AKAADPRIVQ VMAGLTCEYD
     MVYLARLDGK HAADIRPMVR LNVTVIARQG ERREQGSAGG GGRYDLAYFD ETLVRQFVDA
     AVKQALTNLE SRPAPAGEMT VVLGNGWPGV LLHEAVGHGL EGDFNRKGTS VFSGRIGERV
     AAKGVTVVDQ GDIAGRRGSL NIDDEGNETR RTVLIEDGIL AGYMQDETNA RLTGTQPTGN
     GRRESYASVP MPRMTNTFME NGGYEPDEII ASIDKGIYAV NFGGGQVDIT GGKFVFSASE
     AWWVEGGRLQ YPVKGATIIG NGPEVLKHVS MIGNDTALDS GVGVCGKEGQ SVPVGVGQPT
     LRIDAGLTVG GSAI
//