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Database: UniProt
Entry: D0WL10_9ACTO
LinkDB: D0WL10_9ACTO
Original site: D0WL10_9ACTO 
ID   D0WL10_9ACTO            Unreviewed;       591 AA.
AC   D0WL10;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   27-SEP-2017, entry version 51.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EEZ79111.1};
GN   ORFNames=HMPREF0972_00464 {ECO:0000313|EMBL:EEZ79111.1};
OS   Actinomyces sp. oral taxon 848 str. F0332.
OC   Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae;
OC   Actinomyces.
OX   NCBI_TaxID=649743 {ECO:0000313|EMBL:EEZ79111.1, ECO:0000313|Proteomes:UP000003063};
RN   [1] {ECO:0000313|EMBL:EEZ79111.1, ECO:0000313|Proteomes:UP000003063}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0332 {ECO:0000313|EMBL:EEZ79111.1,
RC   ECO:0000313|Proteomes:UP000003063};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B.,
RA   Courtney L., Fronick C., Harrison M., Strong C., Farmer C.,
RA   Delahaunty K., Markovic C., Hall O., Minx P., Tomlinson C.,
RA   Mitreva M., Nelson J., Hou S., Wollam A., Pepin K.H., Johnson M.,
RA   Bhonagiri V., Nash W.E., Warren W., Chinwalla A., Mardis E.R.,
RA   Wilson R.K.;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EEZ79111.1}.
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DR   EMBL; ACUY02000005; EEZ79111.1; -; Genomic_DNA.
DR   RefSeq; WP_009198089.1; NZ_GG703879.1.
DR   ProteinModelPortal; D0WL10; -.
DR   STRING; 649743.HMPREF0972_00464; -.
DR   EnsemblBacteria; EEZ79111; EEZ79111; HMPREF0972_00464.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000003063; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003063};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003063}.
FT   DOMAIN      280    416       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      492    561       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     288    295       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   591 AA;  64941 MW;  D499035AB93D9C40 CRC64;
     MSDGNPAKDA WNAATELLRA DGSLSDSQAA FVRMAHPLAW VDEIFMIAVG SEFVKTWIEE
     HVSETMTSML SNILGRSVRI VISVDPSVNE SQPVGTMASS IAPSAVAPSV LAASEDPLPA
     SSLTMPSLAP SSLASSGVEA EEGDASDSAT SDYSQPRYPG MSRSSEHSFS ETAKYRESST
     DVEAGYARPR PRHLDTSGSG DEPLLPSKPD ESHESFTQGI RYVDQTTIAE EALAKRPDTA
     ARSQKARINP RYTFDNFVIG DNNRFATATS LAVAESPGTT YNPLFLYSDS GMGKTHLMHA
     IGNYALNLFP SIKVRYVSAE EFTNAFINSV RDGHQAEFKN QFRTVDILLI DDIQFIGGRD
     STVEEFFHTF NALTNSNKQI VITSDVSPNL LNGFEERMLS RFNSGVTANI DRPNLETRIA
     ILEKKAHSDG FTVPREVNEY IATHMLTNVR EMEGALRRVT AFADLSKQTI SLGLAEMILK
     DLIANPDAIE ITATLIMSQT AGYFDISIEE MISTDRSRVL VSARQVAMYL CREMTELSLP
     KIGHLFGKRD HTTVMHACRK IDKQMAERQT TYNQVSELTS RIKQAAQQAS L
//
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