ID D0Z7E3_DROVI Unreviewed; 8965 AA.
AC D0Z7E3;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Twitchin {ECO:0008006|Google:ProtNLM};
GN ORFNames=DVIR88_6g0033 {ECO:0000313|EMBL:ACY70496.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:ACY70496.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000831; ACY70496.1; -; Genomic_DNA.
DR STRING; 7244.D0Z7E3; -.
DR eggNOG; KOG0613; Eukaryota.
DR eggNOG; KOG4475; Eukaryota.
DR InParanoid; D0Z7E3; -.
DR Proteomes; UP000008792; Chromosome 6.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 39.
DR CDD; cd00096; Ig; 4.
DR CDD; cd05748; Ig_Titin_like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 78.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR PANTHER; PTHR14340:SF21; MYOSIN BINDING PROTEIN C2; 1.
DR Pfam; PF00041; fn3; 38.
DR Pfam; PF07679; I-set; 35.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 39.
DR SMART; SM00409; IG; 38.
DR SMART; SM00408; IGc2; 31.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 21.
DR SUPFAM; SSF48726; Immunoglobulin; 39.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 39.
DR PROSITE; PS50835; IG_LIKE; 31.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 9..102
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 119..209
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 228..321
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 335..426
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 438..531
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 543..635
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 640..728
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 746..835
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1752..1830
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1847..1931
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2125..2222
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2225..2323
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2327..2417
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2424..2520
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2526..2621
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2723..2820
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2826..2920
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2925..3017
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3021..3120
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3126..3221
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3225..3314
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3322..3416
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3423..3518
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3522..3612
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3620..3713
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3719..3814
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3818..3907
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3915..4008
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4014..4109
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4113..4201
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4208..4302
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4308..4407
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4411..4500
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4508..4601
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4604..4702
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4706..4797
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4803..4896
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4902..4996
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4999..5089
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5097..5192
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5198..5292
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5297..5386
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5394..5487
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5493..5587
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5552..5680
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5687..5781
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5787..5882
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5982..6079
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6085..6180
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6184..6273
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6282..6376
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6382..6475
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6482..6577
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6571..6668
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6677..6771
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6777..6872
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6973..7067
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7073..7168
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7174..7269
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7275..7365
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7468..7563
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7569..7664
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7664..7758
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7763..7856
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7861..7954
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 8011..8266
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 8334..8422
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8459..8546
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8664..8752
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8772..8860
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8871..8959
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 836..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1205..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1317..1489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3204..3224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3697..3727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3993..4019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5173..5203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5469..5498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6458..6505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6560..6585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6757..6781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8575..8649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1065
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1077..1093
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1322..1343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1352..1382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1455..1472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5469..5485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8581..8648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 8040
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 8965 AA; 1002934 MW; B19A137D43FDDC69 CRC64;
MGVAEDFAPS FVKKPQLHQE DDGNRLIFEC QLVSSPKPDI EWFRSDNKLT EDARTKFKIQ
PIGDNKFTVV LELDDVVETD AGLYKVKAKN KSGEVSASIN LNFTPADEPK EKQIDGFAPT
FAKKPAIRQE EDGKRLLFEC RVNADPLPNI TWFHNGTTVQ ESPRHRLTID KDVHSYFATL
EIQNVTVEDA GKYKVNAKNE LGESNATISL NFDSDEAPVP ESTDGIKPTF TERPVIRQSE
DGGNVTFECR CVGDPTPTVT WSHGETVLSE GKRYKMSLTL DQKLYHMARL EISSVVSSDQ
GEYRAQAKNK HGSGVATINL NFESGSKKIP DGKSPRFPKK PTIRQEEDIL IMECILEAHP
VPDITWYCSD KQILDNQRTK MTRKAITKDS YVLTLEIQYP TKDDGGNYRC NAINMFGESN
ANIALNFQGA NDANGFAPSF IEKPRIIPNE TGTLITMKCK CKAKPEPTVK WYRGQDLVEK
SKKIKINSTV IAEDTYELTL EIKDPGATDG GTYRCNVKNE YGESNANLNL NIEAEPEPEG
EGPTFIEKPR IISENNGKLV IMECKVKADP KPDIVWFRNG EVIKESNKLK IFMEQRGDQY
YIKLELIDPQ LEDSGLYKCN IKNSLGELNA NLTLNIEIVP VIKDKPKIIK IIKKRTVVIE
CVVVSKFEPK CTWYKETNTV AESKRHVYLV EKTKEGEFAV KLEINEVEDS DKGAYKLVAS
NEKGEAVSQV VNLVDIPEEE RKPSKPDIAR KLVDQKVTES KTFELIISLK NSDRKCKVEW
YKGSTLIRET KDITTTFDGT TARLTFSSAK SEHTSNYKVV VSNELGKDES TCKVTVEKKD
KKKDEKSEQD KEKEEAEKKR KADEEEKKEE IMEEGKQNEE VSNKQEDKKT SEEKAKAEIK
QNDVEENLQK KTEKKKASGD KNEENPLEQK STKADENKKE KRPLEKKPKQ QKENVEKPQT
AVEEVVPEEE KPVKRKSVSE AKAKTVEKPT TKEPNADAFN EPSTNNNLSP DTQEEPAEQI
GLKKVERRAS IVSVKEESKS ETRRKSIIKS HEQTSEEDTK TVSRRSSFAV EENVSESRRS
SVVDKKALEQ VESKKIEANN NPQAIKEEIP KLKPADKRRI PKAVEEQKPA EELPKLRKTS
IAKPKEEPIP EAAKPKAKGK LKAKPKYEEL PEIPDYERPA LEKYEKSDFT PSDFARELEI
PNKMEKPALE TAKKPAEIVP QKNGLPKKTE VVEQPAEEPK TIKLGKGKLP DDEDTRDGAT
LKPVIVEPEA EKPSLMDIIK QRRRSSVRNL MTKEPIQNES FLGVVLKPVV KDAKEQVAPQ
QAKQLHKANI TENFNPTKSS KAQISDMKKP EALATIVDDY ERPKLEKYEP IEFEKTKSEK
PTPVVKSPDQ NTPEVKLPVE DSKEEKPKVP KMQPPAPGDP PKIEVIREKR PSLAPEPPSR
RGSLVPPADT GRRPSLIIND EKKLRPGEVM DTRLLRPGEV GEGQRRRPSI DVRRPSVQDL
EDLINKPSTP LRDIGDGGPP TIIDVQESYS AVEDSTAYLT VGVEGNPAPT FKFYKGVTEI
IEGGRYKFLT DGQTNTITLC MRKCKPNDEG KYKVVVSNIH GEDSAEMQLY VSDSSGMDFR
AMLKKRRYQK WDKEEQDPNW GDLKETEKPL PALKKVERKV ESFLSPLIDQ FAKEGKDKKV
VFEARFSKPN CKPKWLFRKD EVFTGSKFKF KQENDTYQLI ISTPKVEDSG KYTIEIGGVS
STAFLNVEEA DPTYTFTKPL KKKLEGFTRH ETTLECSVSS SMANVSWFKD NQKLESDDPR
YLISKDINGN LKLIIKESVL EDAGQYRCQL DKQPDKTECA LKIVEYPYKF VKVLKSQQCV
EKDTVTLACE IDDAQGDVQW FRNGEEIKPD KRMQVVKDGR KRKLIIKDCK VTDAGQFKCT
TNADQTDAEI IINYQNRFNK KLKDTDAVER EKLVLDVELQ DQTAPCDWKF NGEPIVPNER
IEIKNLGGGK HQLVFNGLDL SDAGEITCES GQLTSTCKLS VRKGESRPNI DCPDEFAEPI
SAPVVIEVPY KVSGTKQTPV EGKLIKDGKP LPLKDVEVAI TDDKITFKIK KPSRDLSGPY
QIKISNAQGE DTKDVNIICQ DVPQPPQDVD VTDVYQTSCV VNFKPPTDDG GSPITKYVIE
RQDLSKKQGW EPVAEVLPNE PRLKKIDDLV PKKQYRFRIR AVNKLGPSDP ATFKNSILAK
DPWDEPGKPK AVDLTDWDKD HADLKWEAPD SDGGDPITSY VIEYKEKFSN DWVPGSEVPG
DARTGTVENL KEGQQYEFRV RAVNRAGPGE PSDKTKPIIA KCRFVKPFLV GDGLKNITVK
KGQTIRYDIK YDGEPEPVAS WIKSNEPLKF DNQRICLEQL ERNSSITIKK SVRNDTGKYK
LVLTNSSGTI ESEAQVVVLD RPLAPGGPFE PEEVRAHRIK MKWKRPPDDG GCEITGYALE
RMDEETGRWI PSGEVGPDET SFDFKGLTPN KKYKFRVKAI NKEGESEPLE TTDAILAKNP
YDPPSPPSQP VIDDYDNKSV SLKWKRPPSD GGRPVTHYVV EFKDKFSPTW SEVAKTEDPT
PECKVEGLKE KMVYQFRVRA VNKAGPSEPS QPTDNHLCKH KNLKPQIDRS TFKRVTIKSG
RTHKWSVDIT GEPVPELHWS WRDDIALTTG DRISIENVDY HTDFVIMNAK RQDSGFYSLK
AENRNGVDRE TVELVVLGKP SSPKGPLAVS DVTATGCKLQ WKKPEDDGGI PIKEYVVEKM
DTATGKWVRV GRSPGEKEPP SFDVTGLNPG SEYMFRVSAV NEEGESEPLT TLVGVVAKDP
FDEPNKPGTP EVIDYDNQSI SLKWTPPKND GGAPIQKYII EKKDKNKPDW EKALEIPGDQ
LEAAVAGLQE YGEYQFRVIA VNKAGPSPPS DASVPQVAKY KKLKPRIDRS NLKPLLIRAG
KPIKYDVNVR GEPVPTITWY QNDKELKPED LPTNCEIQNI PHNTKISIID TVRKHTGTYK
IRAVNEHGED EADVEVNVLA PPGKPKGPLA VKDITKDSCK LKWQKPDDDG GKPITAYQVE
KFDKKQGRWV PVGRASGNDT EFDVKGLQEG HEYQFRVKAI NEEGESEPLE TDGSILAKNP
YDAASKPGTP KIDDYNEHMV KLKWDAPKHD GGAPITGYII EKKDKFSPIW DEVFTTNTPA
PEAIVDGLTE GNVYQFRVRA INKAGTSEPS DPTEPHLAKP RNLKPSINRE KMKPVKVRAG
QTVKFDVDVK GEPAPTLTWS FKEKEVTPSG QLRLDNDDYN TKLVLLDTTR KDTGVYKLKA
ENINGVDEAE VEVIILDKPA KPEGPLEVSD IHKEGCKLKW KKPKDDGGVP LSGYAIEKMD
TATGKWVPCG TVDPEKTEFD VKGLDPNHRY QFRVRALNEE GESEPLETES AITAKNPFDI
SAPPGLPELE DWDEHHVKLK WEPPIRDGGT PITNYIIEVM DKDSGEFVKA SETEGPICKG
VVKKLEEGQQ YKFRVRAVNK AGPSEPSEQT NWHTAKPRFL KPHIDRTNLK PVIVKAGLSI
SLDINVKGEP APKVEWLFNG LPVISDEEGI KIDNVDYNTK FFVMRAKRPQ SGKYTIKATN
EVGEDVADLD VTVLGKPGKP KGPLEVNDMT KHSCKLKWEK PEDDGGAPID YYEIEKLDPH
TGQWLPCGKS AEPEAKVIGL HEGKPYKFRV RAVNKEGESE DLETDKPVIA KNPFDEPDKP
GRPEPTNWDK DFVDLAWDPP KNDGGAPIQK YIIQMRDKSG RAWVDAATVP SDKTKGTVTA
VEEGHEYEFR VVAINKAGPS EPSDVSKSVV AKPRFLKPHI DRKNLQKKIM RSGQMLHMDA
AVKAEPPAKI TWTYNGAEIK TSDKIKIENE EYKTTFIMPK VRRADKGTYI VTAKNDSGVD
TVDVELEVLC KPSKPKGPLA VSDVTAESVH LKWHKPDDDG GEPIEHYVVE RMDTETGRWV
PVLTTKTPEA DVTGLTEGKE YLFRVKAVNA EGESEPLVTD TPVTAKNPYD AADTPGKPQI
TDWSANHADL KWRAPDDDGG APITGYIIEK KDNNTGKWQK VLETNTPDCK TRVNDLIEGT
KYQFRVKAVN KAGQSKPSEA SDQMSAKDRF AAPKIDRTNI KDITVKAGQH IRFDIKVSGE
PPPSKTWFHN KARIDDDDYN IDIESYRTKL AVPFAKRLHS GKYTIKAENE SGHDEASFEV
TVLDKPAPPE GPLRVTDVHK EGCKLKWNPP MDDGGLPIEH YVVEKMDVET GRWLPSGRFK
EPFAELNNLE PGHEYKFRVL AVNTEGESEP LVGEHSIVAK NPFDEPGKPG TPEPVDWDKD
RVDLVWRPPL NDGGSPITGY VVEKREKGTD KWIKGAEINA PALGEECKAS VPNLDENCEY
EFRVKAFNAA GSGEPSDASK SVITRPRKLA PKIDRKNIRT YNIKAGEPIF LDINVSGEPA
PEISWTQNGK IVYSTPATKI ENVPYNTKYI NSNPERKDTG LYKIAAHNLY GQDQVEFQIN
VITKPGKPEG PLEVSDVHKD GCKLKWKKPK DDGGEPIDSY LVEKFDPDTG VWLPVGKSAV
PEITVDGLIP GHEYKFRVKA VNKEGESEPL ETLGSIIAKD PFTAPSKPGV PETTDWTANK
ADLAWNESAS DGGSPITGYI IEIKDKYSPL WEKALETDSP SPVATVNGLI EGNEYQFRVI
ALNKGGQSEP SEASKPFIAK PRYLAPKIDR RNLRDVTISA GTALKLDAVI TGEPAPKVEW
KFSNYPLQSG KNTTIETPDY YTKLVIRPTQ RGDSGEYLVT ATNSSGKDSV LINVNITDKP
TPPNGPLQIS DVHKEGCHLK WKRPNDDGGT PIEYFQIDKL DPETGYWLPC GRSTEPQADI
TGLTPGNEYK FRVSAVNAEG ESAPLVGEES IIAKNPFDEP GKPENLRATD WDKDHIDLAW
TPPLNDGGSP VTGYLVEKKD KYGQWEKALE VPADQCKGTV PDLTEGEAYE FRVSAINAAG
LGEPSDATAP IVAKSRNKPP VIDRSNLIEV RIKAGQAFTF DCKISGEPAP KTKWLLKKKE
VFSKDNIKVT HIDYNTKLKV TNANRSDSGL YTVHAENYNG EDSADVKVTV IDKPSPPNGP
LKVENVHAEG CTLNWNPPDD DGGQPIENYA VEKMDEATGR WVPAGESHGP VTSLKLKGLT
PGHKYKFRVR AKNRQGTSDP LTTHHATEAK NPYDEPTKPG TPSIKDFDKD FVDLEWARPE
SDGGSPISGY IIEKRDKYSP NWEPCAEIDG DVTSGHVSDL IEGVKYEFRV RAVNKAGQGV
PSDATEPHVA RAKNVAPKID RNFMLDIKIR AGNVFEFDVP VSGEPIPSKE WTHEDNMVIN
TDRVKISNYD DRTKLRILDA KRADTGSYTL VARNINGIDK HTVKVTVLDV PTAPEGPLRG
DEITKNSMTL RWRPPKDDGG SEITHYVVEK MDNEAMRWVP VGECAGTEIR ADNLIENHDY
NFRVRAVNKQ GQSQPLTTSQ AITAKDPYSH PDKPGQPQAV DWGKNFVDLE WAAPKRDGGA
PITSYIVEKR PKFGQWERAT VVPGDERKAH IPDLTDGGEY EFRVIAVNRG GQSDPSDPSG
TIVCKPRFLA PFFDKSLLDN ITVHAGKRLG WTLPIEASPR PTIKWLFNGK EIEPSTRIES
NLFQNELTFE IPSALRADEG RYTLILKNEH GSFDASAHAT VLDRPSPPKG PLDISKITRD
GCHLAWHVPD DDGGSPILHY IIEKMDLSRG TWSDAGMSTH PVHDVIRLVH CKEYLFRVKA
VNAIGESEPL EASKSIIAKN EFDEPDSPSK PIVTDWDRDH VDLQWAAPKS DGGAPLTEYI
IQKKEKGSPY WVNVVHVPPN KTAATVPDLV EGQEYEFRVI AVNQAGQSEP SEPSDMIMAK
PRFLAPKIIT PLNEVRIKAG LIFHIDIDFI GEPAPEAIWT HNLNSLKSNE RSTITTIGHH
TVVHTVNCQR SDSGIYHLLL RNDSGIDEGS FELIVLDRPG PPDGPLEYEE ITANSVTISW
KPPKDNGGSE ISAYVIEKRD LTHGGGWVPA VSFVNAKYNH AVVPRLLEGT KYEFRVMAEN
LQGRSDPLTS EQPVIAKNQY TVPGAPGKPE LSDSDKDHIT IKWKQPISNG GSPILGYDIE
RRDVNTGRWI KINGEPVPTT EYRDDRVSPN HQYQYRVSAV NAAGNSKPSE PSSTFNARPM
REKPRLYLDG LVGRRIKVRA GEPVNVNIPI SGAPTPTIEW KRGDVKLPES KNVSYDTNSE
RTIFRIDDST RQDSGVYKIT ATNEFGKDSA DVKIIVVDKP TPPEGPLTYT ETAPDHISLQ
WNPPKDDGGS EITGYIIEFT EFSVDDWKPV PGYCPKTNYT VKGLTEGKKY LFRVRAENIY
GVSDALEGKP VVAKSPFDPP GAPSQPQVVA YTPSSASLEW HPPDYCGGKP ISGYIVERRE
RGGEWIKCNN YPTPNTSYTV PDLREGARYE FRVIAVNEAG PGSPSKPSEP MTAELQRYRP
DPPEPPKPDR ITKDSVTLSW RPPRNDGKSK IKGYYIEMRP KNSKDWKPVN DIPIHSTVFR
VPDLKEGEEY WFRVIAENDV GRSDPSKPSQ PITIEEQPNK PRMDLGGVRD IICRAGDDFS
IHVPYVGFPK PTASWYSNDT VLDDDQRVHQ HLTDEAASFV VKNSKRSDSG QYRLQLKNPS
GFDTATINVK VLDRPGPPTN LRADEFAGDS LTLYWNPPKD DGGSPVQNYI IEKKEARSST
WTKVSSYCTV PFVRIRNLTI GKEYDFRVIA ENKYGQSDPA NTSEPIRARH PFDVPNAPGI
PRGIDSTEDS ITIAWSKPKH DGGSPITGYV IEKRLLSEDK WTKAIHALCP DLTCKIPNLI
ENAEYEFRVA AVNAAGQSLF SASSDLIYCR RPPHAPKITS DLSIRDMTVI AGEEFHITVP
YHANPRPVPS WNINGLEVSP DERIRFDTDD YSSVYHNKCA KRSETGSYTI TLVNSKGSDT
ASCHVTVVDR PGPPQGPLNA YDITPDTCTL AWKTPLDDGG SPITNYVVEK LDTSGTWVKV
SSFVRNTHYD VMGLEPNHKY HFRVRAENQY GLSDPLEIPE PITAKHQFTV PDEPGQPKVI
DWDSGNVTLI WTRPASDGGS RIQGYQIEYR DIVNDSSWNT YEYLIKDTKY QLYNLTNGSE
YEFRIKAKNA AGFSKPSPPS LRFKLKGKFN VPAPPGTPQV TKVGKNYVDL KWEKPISDGG
SRITGYIIER RDIGGAVWVK CNDYNVLDTE FTVINLIEMG DYEFRIFAIN AAGRSEPSLC
TMPIKVCEVL GGEKPDWISR LQDRIAPSGK DFTLQCAASG KPSPTARWLR NGKEIQMQPG
GRFICDSKDG VFRLHISNVQ SGDDGDYTCE AINSLGFVHT SGYLKVGSPP IINRCPSELY
LPESDNTKIK VYYSGDQPLS VKITKNNELI SDGADESHFK YTIFDEYIAI FIRDIIKSDA
GNYQIELSND SGSATGHFDA YITGLPSAPV GPMGISHINK HSCTLAWRPP ANVGGLRITH
YVVERKDITS PHWITVSSSC KDTSFNVQGL LENQEYIFRV MAVNENGIGA PLEGLNPIRA
KAPIDPPSPP GIPEITEIGG DFVHLEWAKP ESDGGAHIQG YWVDKREVGS DTWQRVNPII
NAANQINCHN LIEGRQYEFR IFAQNIAGLS KESTASQVVK IVDPKAATAP IIVKSLRDAN
CIQNHNAQFT CTITGVPRPT ITWYKGAREI TSGARYYIYS EGDNHFLNIN DVFGEDADEY
VCRAVNKAGA KSTRAALAIM TAPKLNVPPR FRDTAYFDKG ENVVIKIPFT GFPKPRIHWV
REGENIESGG HYNVEVKERH AVLTIRDGSR LDSGPYRITA ENELGSDTAI IQVQISDRPD
PPRFPVVESI GTDSLSLSWK APIWDGGSDI TNYYVERREH PLSSWIRVGN TRFTSMAVTG
LTPGKEYDFR VFADNVYGRS DASDISTLIK TKESIKKKPV ERKWELDESG KRIRGKADGP
IKDYDSYVFD IFSKFVPQPV EISHESVYNR YDILEEIGNG AFGVVHRCRE RSTGNIFAAK
FIPVSHAVEK DLIRREIDIM NQLHHQKLIN LHDAFEDDDE MVLILEFLSG GELFERITAE
GYVMTEAEVI NYMRQICEGI RHMHEKNIIH LDIKPENIMC QTRTSTNVKL IDFGLATRLD
PNEVVKITTG TAEFAAPEIV NREPVGFYTD MWATGVLAYV LLSGLSPFAG DNDVQTLKNV
KACDWDFDLE AFKHISDEGK DFIRKLLIAS KEKRMTAHEC LLHPWLTGDH RELNQKIARD
RYLAYREKLR KKYEDFGKYL LPIGRLAEYS SLRKLLMEKY KMHDAVFDRR QAAPRFVIRP
SSQFCYEGQS VKFYCRCIAI ATPTLTWSHN NIELRQSVKF MKRYAGDDYY FIINRVKLDD
RGEYIIRAEN HYGSREEVVF LNVHPLPKEQ PKYRTESTPV RRREPLPYTL WQEESESAPS
FTFLLRPRVM QARDTCKLLC CLSGKPVPTV KWYKDGRELS KYEYAMTHSD GVVTMEIIDC
KPSDSGKYTC KATNCHGTDE TSCVVIVEGE WVTPEQAELA HNFLYSGDRK YIEQHFKPTP
PPIITTRQFT SSATSSNSQQ TSSTRTTSDG KTVITNSSSS TQNSISSKKK YAASSLQAPG
SPSRSRSATK ELILPPDDSL MCKPEFTKPL HDLTISDGEQ LLLTCHVKGD PEPQITWSKN
GKSISSSEIM DLKYKNGIAT LTIHEVFPED EGVFSCTATN SISSVETKCK LTIKPLDKQS
SKRLPTGSDK PPKIVSHLES RFVKDGDAVT LACRIIGADH FDVVWLHNNK EIKPSKDFQY
SNEANIYRLQ IAEIFPEDGG TYTCEAFNDA GESFSTCTIN VNVPGDEPKV PTFVKFPVSV
SVTEGENATF ECESDGELIN LAWLKDGKPI DEARARYSFT KDSNRYKFSV NKCTLDDVGQ
YQARAVSKKG ESLCAFSVNV LSSEA
//
