ID D1A7W4_THECD Unreviewed; 360 AA.
AC D1A7W4;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Peptidase M24 {ECO:0000313|EMBL:ACY98486.1};
GN OrderedLocusNames=Tcur_2944 {ECO:0000313|EMBL:ACY98486.1};
OS Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC
OS 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=471852 {ECO:0000313|EMBL:ACY98486.1, ECO:0000313|Proteomes:UP000001918};
RN [1] {ECO:0000313|EMBL:ACY98486.1, ECO:0000313|Proteomes:UP000001918}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 /
RC NCIMB 10081 / Henssen B9 {ECO:0000313|Proteomes:UP000001918};
RX PubMed=21475583; DOI=10.4056/sigs.1453580;
RA Chertkov O., Sikorski J., Nolan M., Lapidus A., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA Mavromatis K., Mikhailova N., Ovchinnikova G., Pati A., Chen A.,
RA Palaniappan K., Djao O.D., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Brettin T., Han C., Detter J.C., Rohde M., Goker M., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of Thermomonospora curvata type strain (B9).";
RL Stand. Genomic Sci. 1:13-22(2011).
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|RuleBase:RU000590}.
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DR EMBL; CP001738; ACY98486.1; -; Genomic_DNA.
DR RefSeq; WP_012853270.1; NC_013510.1.
DR AlphaFoldDB; D1A7W4; -.
DR STRING; 471852.Tcur_2944; -.
DR KEGG; tcu:Tcur_2944; -.
DR eggNOG; COG0006; Bacteria.
DR HOGENOM; CLU_017266_4_0_11; -.
DR OrthoDB; 9806388at2; -.
DR Proteomes; UP000001918; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01092; APP-like; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR46112; AMINOPEPTIDASE; 1.
DR PANTHER; PTHR46112:SF8; CYTOPLASMIC PEPTIDASE PEPQ-RELATED; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590};
KW Reference proteome {ECO:0000313|Proteomes:UP000001918}.
FT DOMAIN 8..134
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 142..343
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
SQ SEQUENCE 360 AA; 37903 MW; C3A677D27FDBF1B8 CRC64;
MSDLHAERRR RLAGLVAADG HDAALITRLV NVRYLTGLAS SNAALLVPAD GEAVLATDSR
YAGTAAALCP GLETVIDRDT AGTLLKRAAG AGVRTLAFEA HDLTVERHAE LTEKAGEGTS
LVPLGRRVEQ LRTVKDESEI ALLRQACAIT DEAFAAVLPL IRPGLTERQL AVELERRMVD
LGAEAPAFES IVAAGPNGAI PHHRPGDRPL AEGDLVTMDF GARCGGYHAD MTRTVAIGRV
ADWQREIYQL VAAAQRAALQ AIVPGADVHD VDAAARNMID EAGHGADFPH GLGHGVGLEI
HEAPLLGYGK TGKLSGRVPI TAEPGVYLAG RGGVRIEDTL VVRADGPEIL TKTTKDLLVV
//
