ID D1AL79_SEBTE Unreviewed; 294 AA.
AC D1AL79;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:ACZ09222.1};
GN OrderedLocusNames=Sterm_2369 {ECO:0000313|EMBL:ACZ09222.1};
OS Sebaldella termitidis (strain ATCC 33386 / NCTC 11300).
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Leptotrichiaceae;
OC Sebaldella.
OX NCBI_TaxID=526218 {ECO:0000313|EMBL:ACZ09222.1, ECO:0000313|Proteomes:UP000000845};
RN [1] {ECO:0000313|Proteomes:UP000000845}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33386 / NCTC 11300 {ECO:0000313|Proteomes:UP000000845};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Mikhailova N., Sims D., Meincke L., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.F., Hugenholtz P.,
RA Woyke T., Wu D., Eisen J.A.;
RT "The complete chromosome of Sebaldella termitidis ATCC 33386.";
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACZ09222.1, ECO:0000313|Proteomes:UP000000845}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33386 / NCTC 11300 {ECO:0000313|Proteomes:UP000000845};
RX PubMed=21304705;
RA Harmon-Smith M., Celia L., Chertkov O., Lapidus A., Copeland A.,
RA Glavina Del Rio T., Nolan M., Lucas S., Tice H., Cheng J.F., Han C.,
RA Detter J.C., Bruce D., Goodwin L., Pitluck S., Pati A., Liolios K.,
RA Ivanova N., Mavromatis K., Mikhailova N., Chen A., Palaniappan K., Land M.,
RA Hauser L., Chang Y.J., Jeffries C.D., Brettin T., Goker M., Beck B.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA Klenk H.P., Chen F.;
RT "Complete genome sequence of Sebaldella termitidis type strain (NCTC
RT 11300).";
RL Stand. Genomic Sci. 2:220-227(2010).
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DR EMBL; CP001739; ACZ09222.1; -; Genomic_DNA.
DR RefSeq; WP_012861816.1; NC_013517.1.
DR AlphaFoldDB; D1AL79; -.
DR STRING; 526218.Sterm_2369; -.
DR KEGG; str:Sterm_2369; -.
DR eggNOG; COG0656; Bacteria.
DR HOGENOM; CLU_023205_2_3_0; -.
DR Proteomes; UP000000845; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd19138; AKR_YeaE; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43638; OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR43638:SF3; OXIDOREDUCTASE, ALDO_KETO REDUCTASE FAMILY PROTEIN; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000845}.
FT DOMAIN 27..278
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 65
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 123
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 90
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 294 AA; 33215 MW; 00A3C2622312D3CF CRC64;
MKNTDRIKNE NFQRNVELRD GSLVNAIGQG TWHMGEKHSE RAKEIKALRL GIDLGMTLID
TAEMYGSGGA EEVTGEAVKG IRDKIFIVSK VYPQNAGKKR AVLSCENSLK RLGTDYIDLY
LLHWRGGIPL HETVEVMEQL VKEGKIKRWG VSNFDTKDME ELWKIPDGSN CAVNQVLYHL
GSRGIEYDLL PWCREKKLPV MAYCPVAQGG ILRKELLANK TVRRIAGERG ISEVQVLLAW
TVREKDIISI PKAVQENHIY ENAETAGIFL SGEEIRDLEL EFPAPDTKVW LDIV
//
