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Database: UniProt
Entry: D1J7E1_MYCHP
LinkDB: D1J7E1_MYCHP
Original site: D1J7E1_MYCHP 
ID   D1J7E1_MYCHP            Unreviewed;       463 AA.
AC   D1J7E1;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   05-JUL-2017, entry version 62.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000313|EMBL:CAX37138.1};
GN   OrderedLocusNames=MHO_0040 {ECO:0000313|EMBL:CAX37138.1};
OS   Mycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 /
OS   PG21).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=347256 {ECO:0000313|EMBL:CAX37138.1, ECO:0000313|Proteomes:UP000002631};
RN   [1] {ECO:0000313|EMBL:CAX37138.1, ECO:0000313|Proteomes:UP000002631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21
RC   {ECO:0000313|Proteomes:UP000002631};
RX   PubMed=19816563; DOI=10.1371/journal.pgen.1000677;
RA   Pereyre S., Sirand-Pugnet P., Beven L., Charron A., Renaudin H.,
RA   Barre A., Avenaud P., Jacob D., Couloux A., Barbe V., de Daruvar A.,
RA   Blanchard A., Bebear C.;
RT   "Life on arginine for Mycoplasma hominis: clues from its minimal
RT   genome and comparison with other human urogenital mycoplasmas.";
RL   PLoS Genet. 5:E1000677-E1000677(2009).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; FP236530; CAX37138.1; -; Genomic_DNA.
DR   RefSeq; WP_012855285.1; NC_013511.1.
DR   STRING; 347256.MHO_0040; -.
DR   EnsemblBacteria; CAX37138; CAX37138; MHO_0040.
DR   GeneID; 25040389; -.
DR   KEGG; mho:MHO_0040; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000280343; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002631; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002631};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002631}.
FT   DOMAIN      153    288       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      369    438       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   463 AA;  52902 MW;  B0A97BB08204260A CRC64;
     MKTTNPSELD LKAHNMSFQK ELVNTASDPL IYDQFLSSLE IVKENNKMIY ILVKGPEDVL
     TYIKNSHNES IKRAIKNVYG EEYNLVYIRN LDEIKSLQNS NNIESPTNSL TNNSKENFSN
     IKKNLTFDDY AIGKFNNMAL KAAKAICNSE KILFSPLFIH ASSGLGKTHL LHAIGNELLK
     HGRSALYINP DSLTRRLVEQ LKSKNQEQIN KIIDELMSYD CLMFDDVQQY GNRDSTLNVL
     FNIIDNMIMN DKQIIFCGDK KPDDLGGFEQ RFITRFNGGL TVEILKPELN DVINILKFKL
     QENGINPELW EEESLKFIAR NFSSSIRNIE GAINRIKLFQ DGDDGFFTYD INTIKSIFNS
     MTQVAENITP DKIIDAVSKY YKIDRKKILS NVRTNDVVNA RRIATYLVNK NFNYTLQEIG
     KVVGNQSHSN VIVSLNWIEK NANSNPTLKL ALQKIESNLK KIS
//
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