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Database: UniProt
Entry: D1VS86_9FIRM
LinkDB: D1VS86_9FIRM
Original site: D1VS86_9FIRM 
ID   D1VS86_9FIRM            Unreviewed;       629 AA.
AC   D1VS86;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   24-JAN-2024, entry version 67.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149,
GN   ECO:0000313|EMBL:EFA90528.1};
GN   ORFNames=HMPREF0628_0669 {ECO:0000313|EMBL:EFA90528.1};
OS   Peptoniphilus lacrimalis 315-B.
OC   Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC   Peptoniphilus.
OX   NCBI_TaxID=596330 {ECO:0000313|EMBL:EFA90528.1, ECO:0000313|Proteomes:UP000005711};
RN   [1] {ECO:0000313|EMBL:EFA90528.1, ECO:0000313|Proteomes:UP000005711}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=315-B {ECO:0000313|EMBL:EFA90528.1,
RC   ECO:0000313|Proteomes:UP000005711};
RA   Durkin A.S., Madupu R., Torralba M., Methe B., Sutton G., Strausberg R.L.,
RA   Nelson K.E.;
RT   "Genome Sequence of Peptoniphilus lacrimalis 315-B.";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFA90528.1}.
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DR   EMBL; ADDO01000021; EFA90528.1; -; Genomic_DNA.
DR   RefSeq; WP_004824056.1; NZ_ADDO01000021.1.
DR   AlphaFoldDB; D1VS86; -.
DR   eggNOG; COG0323; Bacteria.
DR   Proteomes; UP000005711; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd00782; MutL_Trans; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00149};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000005711}.
FT   DOMAIN          208..326
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          443..586
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
SQ   SEQUENCE   629 AA;  72553 MW;  01FFE23775762D53 CRC64;
     MSIVLLDDNT ISKISAGEII ENPASVVKEL LENSIDAGAK NITVEVKNSP TDFIRITDDG
     CGFKADEIEL AFMRHSTSKL SKIEDLEELT TLGFRGEALA SISSIAKIRL LTKNSEDLAG
     TSSKIENGKI IEQSNVGMPH GSTFYVEDIF YNTPVRKKFL RADNVEFNLI FDVIQKIALG
     NPQVSISYIR DGKTLLNSYK NSNYKNHILN VLGREIATNL IENSFSSENY KIRAYFSNNK
     LFRSSRNHQY IYINGRYVTN REISREIEKV YKSLIPLNRF PVFILFIDIN SSLIDVNIHP
     KKHEVKLSNE NNLIAILCEM VEEVLYPNRS IREIEDEPKV NLNVFDIFDD KSNDNLINFR
     EPTYEPGDND IKEFDIDSQS FYENYQPFDM NKENLDNNND IDNIEDKTED FNYDNIPSLE
     QFQEDSFLND KEVIDSNLIN TRIVGILFDT FIILENKDKD LIYLVDQHAA HERVMYEKYK
     KQYLNSNINS QVLLKPEIIE LNASEYMKIE KNFKLFKDLG FSIDSFGENS IILREVPMIF
     GFPTYVSFIR DIIDSLDDKI YSNYQADMWK VMKRACLKAV KAGDTLSNME VKELINSLIH
     CENPYTCPHG RPTIIDIKKT TIAKLFLRE
//
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