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Database: UniProt
Entry: D1YVW6_METPS
LinkDB: D1YVW6_METPS
Original site: D1YVW6_METPS 
ID   D1YVW6_METPS            Unreviewed;       557 AA.
AC   D1YVW6;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   Name=mcrA {ECO:0000313|EMBL:BAI60588.1};
GN   OrderedLocusNames=MCP_0516 {ECO:0000313|EMBL:BAI60588.1};
OS   Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS   SANAE).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanocellales;
OC   Methanocellaceae; Methanocella.
OX   NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI60588.1, ECO:0000313|Proteomes:UP000001882};
RN   [1] {ECO:0000313|Proteomes:UP000001882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC   {ECO:0000313|Proteomes:UP000001882};
RX   PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA   Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA   Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA   Mori K., Fujita N., Imachi H., Takai K.;
RT   "Genome sequence of a mesophilic hydrogenotrophic methanogen
RT   Methanocella paludicola, the first cultivated representative of the
RT   order Methanocellales.";
RL   PLoS ONE 6:E22898-E22898(2011).
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
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DR   EMBL; AP011532; BAI60588.1; -; Genomic_DNA.
DR   STRING; 304371.MCP_0516; -.
DR   EnsemblBacteria; BAI60588; BAI60588; MCP_0516.
DR   KEGG; mpd:MCP_0516; -.
DR   PATRIC; fig|304371.9.peg.531; -.
DR   eggNOG; arCOG04857; Archaea.
DR   eggNOG; COG4058; LUCA.
DR   HOGENOM; HOG000225809; -.
DR   KO; K00399; -.
DR   OMA; GRVCDGG; -.
DR   OrthoDB; POG093Z00ZI; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000001882; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001882};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000001882};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262}.
FT   DOMAIN        7    275       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      323    448       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       154    154       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     264    264       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     278    278       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   557 AA;  60792 MW;  E468823855704C42 CRC64;
     MSVKETQKRF IKAMKKKFAG EDPTSTTTVY KYEGYTQSKR KVEFKKAGDA IAKKRGISAY
     NPMVHMGGIP LGQRQLTPYV VSGTDVVVEG DDLHFVNNAA MQQFWDEIRR TVIVGLDTAH
     ATLEKRLGKT VTPETISNYL AILNHAMPGA AVVQEHMVET NPALTDDCFV KVFTGDDELA
     DSIDKQYVLD INKAFPKDQA AALKKAVGKS LYQAVHIPTT VVRTCDGGTT SRWSAMQIGM
     SFIDAYKMCA GEAAVADLAF AAKHASLVEM ADILPARRAR GPNEPGGLSF GFLADIVQTN
     RKYPDDPCKS SLEVVAAGCM LYDQIWLGSY MSGGVGFTQY ATAAYTDDIL DDFTYYGYDY
     AKGKYKIGQT KPTMDIVNDL STEVTLYGIE QYEKYPTTLE DHFGGSQRAT VLSAAAGVTT
     AIATGNSNAG LSGWYMSMYL HKEAWGRLGF FGYDLQDQCG ATNVFSCRSD EGAIDELRGP
     NYPNYAMNVG HQGGYAGIAG AAHFGRGDAW TASPLIKICF ADKSLAFDFT EPRKEFARGA
     IREFMPAGER TLVIPAK
//
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