ID D1YYX0_METPS Unreviewed; 686 AA.
AC D1YYX0;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Formate dehydrogenase alpha chain {ECO:0000313|EMBL:BAI61642.1};
GN Name=fdhA-1 {ECO:0000313|EMBL:BAI61642.1};
GN OrderedLocusNames=MCP_1570 {ECO:0000313|EMBL:BAI61642.1};
OS Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS SANAE).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanocellales; Methanocellaceae; Methanocella.
OX NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI61642.1, ECO:0000313|Proteomes:UP000001882};
RN [1] {ECO:0000313|Proteomes:UP000001882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC {ECO:0000313|Proteomes:UP000001882};
RX PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA Mori K., Fujita N., Imachi H., Takai K.;
RT "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella
RT paludicola, the first cultivated representative of the order
RT Methanocellales.";
RL PLoS ONE 6:E22898-E22898(2011).
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; AP011532; BAI61642.1; -; Genomic_DNA.
DR AlphaFoldDB; D1YYX0; -.
DR STRING; 304371.MCP_1570; -.
DR KEGG; mpd:MCP_1570; -.
DR PATRIC; fig|304371.9.peg.1606; -.
DR eggNOG; arCOG01492; Archaea.
DR InParanoid; D1YYX0; -.
DR OrthoDB; 23466at2157; -.
DR Proteomes; UP000001882; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR CDD; cd02790; MopB_CT_Formate-Dh_H; 1.
DR CDD; cd02753; MopB_Formate-Dh-H; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041925; CT_Formate-Dh_H.
DR InterPro; IPR041924; Formate_Dh-H_N.
DR InterPro; IPR006478; Formate_DH_asu.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR NCBIfam; TIGR01591; Fdh-alpha; 1.
DR PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
DR PROSITE; PS00490; MOLYBDOPTERIN_PROK_2; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 3..59
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 686 AA; 75552 MW; C7E46534019A5606 CRC64;
MDMKIVPTTC PYCGTGCGLN LVVKDGKVVS VAAWQRHPVN EGKLCPKGRY AHEFIHRPDR
LTKPLIKKDG KFVEATWDEA YDLVAKKLKS FKPEEVMCLS SARVSNEENY LMQKFARTVI
KTPHVDHCAR LCHASTVVGL AGAFGSGAMT NDIGGIAESK CIFVLGSNTV EQHPLIGRKI
VQAKQKGAKV ICFDPRFTPT ARLADLYASF YSGTDVALLN GLMQHIIKNG WEAKDYIATR
TKDFEKVKAV VMKPEYSLDN VSRITGIAVK DLETAAEWFA KSPASCLCYS MGITQHTTGV
DNVKSVANLL MLTGNVGKIG GGVNALRGQN NVQGACDMGA LPNVYSGYQN VTLEPSQTKM
KEAWGCEIAP GKVGYTVTDA INVLCDSPPK LKAIYIMGEN PMVSDPDLHH VEKALKNLEF
LVVQDIFLTE TAQLADVVLP ASCFAEKDGT QTSTERRVQR FRKAVNPPGD AKVDWQIICE
LAAKMGCAKQ FPFKSAEEIF NEVAKVTPSY AGMSYARIEK PEALHWPCPT PEHPGTPVLH
TQKFSHPDGL GVFTPIEFKP PAEVPDAEYP FILTTGRCIW QWHTGSMTRR SSSLEREEPE
SWLEINTEDA KALGIQNREV VRAITRRGEV KVAARVTPDI KRNEVFMPFH YAECAANTLT
NNALDPTAKI PEFKACAVRV EKIKEA
//
