ID D2A0J4_TRICA Unreviewed; 1275 AA.
AC D2A0J4;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 2.
DT 28-JUN-2023, entry version 61.
DE SubName: Full=Interference hedgehog-like Protein {ECO:0000313|EMBL:EFA01677.2};
GN Name=AUGUSTUS-3.0.2_07250 {ECO:0000313|EMBL:EFA01677.2};
GN ORFNames=TcasGA2_TC007250 {ECO:0000313|EMBL:EFA01677.2};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA01677.2, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA01677.2, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA01677.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA01677.2, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA01677.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971338; EFA01677.2; -; Genomic_DNA.
DR AlphaFoldDB; D2A0J4; -.
DR EnsemblMetazoa; TC007250_001; TC007250_001; TC007250.
DR HOGENOM; CLU_004633_0_0_1; -.
DR Proteomes; UP000007266; Linkage group 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR CDD; cd00063; FN3; 2.
DR CDD; cd22343; PDDEXK_lambda_exonuclease-like; 2.
DR Gene3D; 3.90.320.10; -; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR019080; YqaJ_viral_recombinase.
DR PANTHER; PTHR39953; RE54151P; 1.
DR PANTHER; PTHR39953:SF1; RE54151P; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF13927; Ig_3; 3.
DR Pfam; PF09588; YqaJ; 2.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 2.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1174..1198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 637..713
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 730..814
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 819..902
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 939..1047
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1053..1149
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 1275 AA; 143802 MW; 96127BB40B04BEDC CRC64;
MIGFIYVRGI YRSSTEDEII QFRAEIGVTN VVGFTWLLRP EASEEARKII ADIEEILQSL
EYVQAIDKQK FLLEKCRIDE ARIKLVEACT RGQHVNENWH VARKHRLTAS RFGMVLSACS
RRRFPPSLFK NLAEGYSLDR VAAVQWGKTH EKTALREFEE ATNLKVQETG FWLEESGFLG
ASPDGLVEED GILEIKCPYK YRDTDSLSEA LKDKKYFYWR DENEDINLNS NHNYYHQVQG
QMHITGRKVI KLADVYKPKL SNYTALSRSS TEDEIIQFRA EIGVTNVVGF TWLLRPEASE
EARKIIADIE EILQSLEYVQ AIDKQKFLLE KCRIDEARIK LVEACTRGQH VNENWHVARK
HRLTASRFGM VLSACSRRRF PPSLFKNLAE GYSLDRVAAV QWGKTHEKTA LREFEEATNL
KVQETGFWLE ESGFLGASPD GLVEEDGILE IKCPYKYRDT DSLSEALKDK KYFYWRDENE
DINLNSNHNY YHQGCSSMDG FRVICILVAV LATTGRATAA DHVRMVTKAD LITVPLNFDT
SIVCTMNIVP DNFQWKFYPL SRRQASNPKA HISLTHSHFE IIDERKYEIT QKKTSTLNLQ
AKSDDIAGDY QCLAYYGASV VASIPWRLTI ANISEFPPQE KIDVTVIPGN TVNWRCEPPE
ANPEPYIDYH KNGVYVPPFV QVVTKSLIIP NVTSGNSGSY TCKAGNVCTE KFSPVLFNLK
VDKRAPREPP KFIVRPRSVY NVTKGDKVLL ECSAVGNPLP KVVWRKITGI IPEGRSELTP
GGLIIKNISA SDNGIYECTH DNSLGKVVHS ITLNYNEAPT INCPQDSIDV NQGEDLELEC
TVTGNPDPEI TWFLNGFVTK DNKIITEGNK IFFKPTEKRH AGNLQVFARN IAGTVYSSIS
IKVIPLSTTQ DNVSENPLPP TRLHRPNSRK FNKHAKMYPP SKPNITGISD EAVVLRWTVQ
NKGLPIQFFK VQYKDFGPAN QHDHHNKGKG SKWNTDNPII EPHIRSYQVN NLKPDHVYRF
RIAAVYSNSD NKNSPNSDKF HLRKLDFDKR NPLPVPLITK TESINTTAVK IYWKCEPSIN
ITIDGFFVNY NSASSAGDYT KATVDGPQTN SFVLSHLQPD TVYDIKLQSF NSKSASDFSS
IMKAKTLGLA STTLSPREPP PSSANTETAG ISKLYVFIAA GVLGACGVLF AAIGLLLFCR
KQSKQKKTGT RGDHDKACDD HHHIQADATE YVVSPKSGPR TNGCVAPNRI TITANPLADA
DNKKFLARIF SRIRI
//
