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Database: UniProt
Entry: D2A144_TRICA
LinkDB: D2A144_TRICA
Original site: D2A144_TRICA 
ID   D2A144_TRICA            Unreviewed;      1059 AA.
AC   D2A144;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   25-OCT-2017, entry version 55.
DE   SubName: Full=Potassium voltage-gated channel protein eag-like Protein {ECO:0000313|EMBL:EFA02607.1};
GN   ORFNames=TcasGA2_TC008326 {ECO:0000313|EMBL:EFA02607.1};
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga;
OC   Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA02607.1, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:EFA02607.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA02607.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=18362917; DOI=10.1038/nature06784;
RG   Tribolium Genome Sequencing Consortium;
RA   Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA   Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G.,
RA   Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M.,
RA   Richards S., Roth S., Schroder R., Tautz D., Zdobnov E.M., Muzny D.,
RA   Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J.,
RA   Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M.,
RA   Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T.,
RA   Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M.,
RA   Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C.,
RA   Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V.,
RA   Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J.,
RA   Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E.,
RA   Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y.,
RA   Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA   Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA   Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA   Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J.,
RA   Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H.,
RA   Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z.,
RA   Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E.,
RA   Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P.,
RA   Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y.,
RA   Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA   Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA   Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P.,
RA   Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F.,
RA   Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E.,
RA   Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M.,
RA   Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R.,
RA   Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S.,
RA   Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R.,
RA   Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y.,
RA   Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A.,
RA   Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G.,
RA   Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W.,
RA   Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z.,
RA   Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J.,
RA   Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A.,
RA   Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J.,
RA   Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y.,
RA   Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P.,
RA   Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S.,
RA   Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA   Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT   "The genome of the model beetle and pest Tribolium castaneum.";
RL   Nature 452:949-955(2008).
RN   [2] {ECO:0000313|EMBL:EFA02607.1, ECO:0000313|Proteomes:UP000007266}
RP   GENOME REANNOTATION.
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA02607.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=19820115; DOI=10.1093/nar/gkp807;
RA   Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA   Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT   "BeetleBase in 2010: revisions to provide comprehensive genomic
RT   information for Tribolium castaneum.";
RL   Nucleic Acids Res. 38:D437-D442(2010).
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DR   EMBL; KQ971338; EFA02607.1; -; Genomic_DNA.
DR   RefSeq; XP_008192655.1; XM_008194433.2.
DR   ProteinModelPortal; D2A144; -.
DR   STRING; 7070.TC008326-PA; -.
DR   EnsemblMetazoa; TC008326_001; TC008326_001; TC008326.
DR   GeneID; 663617; -.
DR   KEGG; tca:663617; -.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   InParanoid; D2A144; -.
DR   KO; K04908; -.
DR   OMA; NKAEVVH; -.
DR   PhylomeDB; D2A144; -.
DR   Proteomes; UP000007266; Linkage group 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003949; K_chnl_volt-dep_EAG.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01464; EAGCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007266};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    222    240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    353    377       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    424    446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    453    473       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       43     95       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN       94    146       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      579    656       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      925    952       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1059 AA;  118786 MW;  9EF341E2295E9BF7 CRC64;
     MPGGRRGLVA PQNTFLENII RRSNSQPDSS FLLANAQIVD YPIVYCNESF CKISGYNRAE
     VMQKSCRCAF MFGELTDKET ISRIDHVLEH QLHDQFEILL YKKNKTPLWL LLQISPIKNE
     RDLVVLFLLT FRDITALKQP IETDDTKGGL SKFAKLARSV TRSRSVLVSQ FSSHLPNLKD
     TTKQSHLAQM MSLSADIMPQ YRQEAPKTPP HILLHYCAFK AIWDWIILCL TFYTAIMVPY
     NVAFKNKTSE DVSLLVVDSI VDVIFFIDIV LNFHTTFVGP GGEVVSDPKV IRMNYLKSWF
     IIDLLSCLPY DVFNAFDHDE DGIGSLFSAL KVVRLLRLGR VVRKLDRYLE YGAAMLILLL
     CFYMLVAHWL ACIWYSIGRS DADNGVQYSW LWKLANITQS PYSYVWPNDT NTPELINGPS
     RKTMYVTALY FTMTCMTSVG FGNVAAETDN ERIFTICMMI IAALLYATIF GHVTTIIQQM
     TSATAKYHDM LNNVREFMKL HEVPKALSER VMDYVVSTWA MTKGLDQDKV LNFCPKDMKA
     DICVHLNRKV FNEHPAFRLA SDGCLRALAM HFTMSHSAPG DLLYHTGESI DSLCFIVTGS
     LEVIQDDEVV AILGKGDVFG DSFWKDNAVG QSAANVRALT YCDLHTIKRD KLLEVLDFYQ
     AFANSFARNL ILTYNLRHRL IFRKVADVKR EKELAERRKN EPQLDQNQDH LVRKIFSKFR
     RDRSQQQSTA NSQHSSDVEK GEESGDKAMT RVMSTTKLSS VAEKDDSSGG GVKTTVARPA
     AGRTSKWGRL LGSASLDSGS ESSTPAQQAF TRSLSAKDTM KERPSSSSSG SSGSQPTPGS
     GNKVFPKLQK VSTNSSPGIT RQDTIEEMVE VEPQHHSRNL SLRKMQSYDC GLRDPSTASM
     YQTPLPDPIA PPEYKELMTN LMDFKVDVKL EIQRLNQKMN RMEELLTELV KRISPESGSS
     SPQGDSEPKP KSSSAGSGPE RPTELLPRPS TSEGTGLGPI ILRKRRSKSR IKGTAPQIPT
     PSSGKVTSPE SSATSPTETT KMLDEPVLTP SSRKPKDFL
//
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