ID D2A4M7_TRICA Unreviewed; 2165 AA.
AC D2A4M7;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE RecName: Full=oleoyl-[acyl-carrier-protein] hydrolase {ECO:0000256|ARBA:ARBA00012480};
DE EC=3.1.2.14 {ECO:0000256|ARBA:ARBA00012480};
GN Name=AUGUSTUS-3.0.2_15337 {ECO:0000313|EMBL:EFA05201.1};
GN ORFNames=TcasGA2_TC015337 {ECO:0000313|EMBL:EFA05201.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA05201.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA05201.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA05201.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA05201.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA05201.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971344; EFA05201.1; -; Genomic_DNA.
DR STRING; 7070.D2A4M7; -.
DR EnsemblMetazoa; TC015337_001; TC015337_001; TC015337.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_7_1; -.
DR InParanoid; D2A4M7; -.
DR OMA; MFIEDID; -.
DR PhylomeDB; D2A4M7; -.
DR Proteomes; UP000007266; Linkage group 6.
DR GO; GO:0019171; F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0004316; F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004313; F:[acyl-carrier-protein] S-acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0016297; F:acyl-[acyl-carrier-protein] hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0047117; F:enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0004312; F:fatty acid synthase activity; IBA:GO_Central.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd08954; KR_1_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR049391; FAS_pseudo-KR.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF23; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF21149; FAS_pseudo-KR; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 18..425
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT COILED 33..60
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2165 AA; 242344 MW; F4F3615F967380CE CRC64;
MNRYDFEYGK WLSSAPPDEQ VVISGISGKF PKCENVTEFL ENLEEKKDML TESKERFKVD
HPELPLKAGL LQGIDKFDAG FFGIHHRQIQ TLYLGLRKLL EITTEAIMDA GIHPEELKGS
KTGVFVGYSW NDSEVEVLAK VTEPQQFAMT GLLRSMVAHR LSYFFKLKGP SHICETACSS
SLVALDHALK ALRSDQCENA IVATCHLTFH PAVTVQFFRL GVLSPDSKCK VFDQEANGYV
RSEAMSCLFL QKSKNARRIY AKILHSKENS DGFKSGGITF PSSPIQGQLL KEMYAESGIN
PNELSYFEAH GTATRVGDVE EVNAIDTILA QNRTEPLYIG SVKSNIGHSE PGSGLSSLIK
VILCMHSGYL LPNINYNRVK QNITGIVDGR LKVVTEKTPL HSPNAIAGVS SFGFGGSNCH
VIVQRWGEDV AQTDGMPRLV CVSGRTEMAV WGFLNELKSK HFDVEFVALV HHVFKHEFSE
HPFRGFVVLG EKGPLSESVR PCPLEKVPLF VKFGPMDKSY QTVGRYFLKF PVFEQTIRRI
GTLLGNDQII ETLKGYKNQV KDPTLLSSYV QLGIIDVLKV LKIDAKLILD GSKAKLISQY
YQNSSLETIL ERIKSQETSN GFERLDVVPK HSLVCDFTDS GPFGTNPEQF LEFLGRLYLN
NYNPQIWQLY PQVKFPVRRT TPFLSPLIKW NHETKWPIPE CKIQAEKLTV SVVFNLEEEA
DKYIEGHVID GRNLFPATGY LYLIWVIYAE NHLTRSAKLA PVVFTNCKFI RATIVPKIGF
LNLVVSIQRE SGFFEIMEND TIVVTGRIQA PQDLKPFKST FKVVENQSEV VLDQYDIYKE
LHLRGYDYTG LFKNLVKCNT EATCGVLKWD NNWVAFMDTM LQIKILQMDT RDLYVPVGIN
KLVIDPIEHL RIIDQVGQVV PINAYKNNNL IKSGGIEISG LYASPISKRK QILEPVLEKY
VFVPNSGTMD LSTITRVNTQ IILENTMEEL FKAVEIVDEV VPETLLMPLI YNALEDVPVV
HPNLIISTKH VLEEVPGVKI ENYSLTNESN LSLIVGTKIL SRSTVLQKVL TSLSKTGYIL
SREDVNFSPI TNVVTVTTYS TTSGEKLVLC KKLEPVKSHN FVKISSDNFN WVQEIQKLPH
DNLVLYSEYP CDGTLGLINC LRREPGGGRI ICVFMMDKAP VFDSLDPIYS QQIAKNLAVS
VYKNGTWGTY RHLRLEDSLE VLREHSFVTC GSRGDLSTLR WVQGPLTVNS DLDLVISNYC
AINFKDIMTA SARITVTLDR INQENIEGIE FSGRKNSQNV MGIISNGALS TLIASDPNLT
WVVPPHWSLE DAATVPVVYA TVIYALLMRS SLNAGTSILI HSGTGGVGLA AINVALAHKC
TVFVTVGTKE KRDFLKKNFP EINERHIGNS RDVSFKEMIL KETRGRGVDV VLNSLSEEKL
KTSVQCLARG GKFMEIGKFD LVNNNSLQLL LLEKEASYHG IMLDTLFKET KERKTGLWLK
VDEGLKKGYI KPLPRTVFES NKVETAFRYM MSGTHIGKVL LKVRDESTDK PKLIKAYPKF
YCDPKKCYIV IGGLGGFGLE LTDWLVLRGA RNLVLTSRTG VQTGYQTQRI KIWQSYGARV
NISTITISSK DDCVKLIQEA TKLAPVDAIF NLAVVLKDEL FENQTEENFR ISLTPKAFAT
KYLDQVSRDL CPNLRFFVVF SSVSCGRGNI GQSNYGMANS IMERVCEKRK SEGFPALAIQ
WGAIGDVGLV AKMQKDNKEL VIGGTLQQKI SSCLNVMDRF LNQDNPVVSS MVVAEKRDKR
LGSGSAVDVV ATILGIKDLK TISHHSTLAE LGMDSMMSTE VMQILEKDFE IFISAKEIRN
LTFTRLKEMG KNSPNQDQNK QKLSQGTKTL IKFIPENCDE TLVTIPSLGT TTSKSLIFVF
PGIEGVLKLL DPLTTNLKSR LLGVQYSYKN PESTIRETAI KILPLIERQL TAKNFNFVGY
SFGALVALEL AQLLEEKGFV GKIVALDGSP HYTKQSIQHY APGESEAETE TMLLYNILGT
VLPLDLLEKS KTDLIKCSNF DERINRAVSL IPEDLAEKHK LEKQAAVTLH QRFKAVRCYT
FGGEKIKSFV KLYKAEVPLV GGMDDDYKLA QLCDNKVEVM TVGGDHTTML EQGELANDLN
KIFEE
//