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Database: UniProt
Entry: D2A5B0_TRICA
LinkDB: D2A5B0_TRICA
Original site: D2A5B0_TRICA 
ID   D2A5B0_TRICA            Unreviewed;       937 AA.
AC   D2A5B0;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 2.
DT   07-JUN-2017, entry version 48.
DE   SubName: Full=Potassium voltage-gated channel protein eag-like Protein {ECO:0000313|EMBL:EFA05339.2};
GN   ORFNames=TcasGA2_TC015503 {ECO:0000313|EMBL:EFA05339.2};
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga;
OC   Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA05339.2, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:EFA05339.2, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA05339.2,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=18362917; DOI=10.1038/nature06784;
RG   Tribolium Genome Sequencing Consortium;
RA   Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA   Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G.,
RA   Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M.,
RA   Richards S., Roth S., Schroder R., Tautz D., Zdobnov E.M., Muzny D.,
RA   Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J.,
RA   Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M.,
RA   Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T.,
RA   Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M.,
RA   Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C.,
RA   Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V.,
RA   Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J.,
RA   Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E.,
RA   Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y.,
RA   Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA   Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA   Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA   Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J.,
RA   Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H.,
RA   Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z.,
RA   Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E.,
RA   Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P.,
RA   Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y.,
RA   Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA   Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA   Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P.,
RA   Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F.,
RA   Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E.,
RA   Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M.,
RA   Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R.,
RA   Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S.,
RA   Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R.,
RA   Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y.,
RA   Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A.,
RA   Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G.,
RA   Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W.,
RA   Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z.,
RA   Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J.,
RA   Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A.,
RA   Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J.,
RA   Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y.,
RA   Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P.,
RA   Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S.,
RA   Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA   Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT   "The genome of the model beetle and pest Tribolium castaneum.";
RL   Nature 452:949-955(2008).
RN   [2] {ECO:0000313|EMBL:EFA05339.2, ECO:0000313|Proteomes:UP000007266}
RP   GENOME REANNOTATION.
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA05339.2,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=19820115; DOI=10.1093/nar/gkp807;
RA   Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA   Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT   "BeetleBase in 2010: revisions to provide comprehensive genomic
RT   information for Tribolium castaneum.";
RL   Nucleic Acids Res. 38:D437-D442(2010).
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DR   EMBL; KQ971345; EFA05339.2; -; Genomic_DNA.
DR   STRING; 7070.TC015503-PA; -.
DR   EnsemblMetazoa; TC015503_001; TC015503_001; TC015503.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   InParanoid; D2A5B0; -.
DR   Proteomes; UP000007266; Linkage group 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01470; ERGCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007266};
KW   Ion channel {ECO:0000256|SAAS:SAAS00091826};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00807593};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00807732};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00807568};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00807693}.
FT   TRANSMEM    156    177       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    293    319       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    356    377       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    384    408       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      487    587       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   937 AA;  105509 MW;  4C3B5A7BE8E2236A CRC64;
     MTDHRLLPPT DIPLIITSTS SSPESSRKIG DRRKASSVGS EKNGKNVNLQ AGGSFKYEIG
     RNRSVSNLIN LPAKWSSVRI KGTGFKESRK SVVKLESCNG LPLKKEFQNL LSPQNQVKKN
     IGDVLSLGAD VLPEYKLQNP RIHNWTILHY SPFKAVWDWI ILILVMYTAI FTPYVAAFLL
     NEPDNNRKNK KYGEDPIVII DLIVDVTFII DILINFRTTY VSGNDEIVSD PVRIAIHYLK
     GWFFIDLVAA VPFDLLFFGS DTDETTTLIG LLKTARLLRL VRVARKIDRY SEYGAAVLLL
     LMATFALIAH WLACIWYAIG NAENHSKIGW LEILANDTHQ FYGPNNTGGP SIKSRYVTAL
     YFTFTSLTSV GFGNVAPNTD AEKIFTICVM LAGSLMYASI FGNVSAIIQR LYSGTARYHT
     QMLRVREFIR FHQIPNPLRQ RLEEYFQHAW AFTNGIDMNS VLKGFPECLQ ADICLHLNRN
     LLQNCSVFDG ASPGCLRAFT LKFKTTHAPP GDTLVHRGDV LSSLYFISRG SIEILRDDIV
     MAILGKYDIF GENPCLHPTL GKSSCNVRAL TYCDLHKIHR DDLLDVLELY PEFYNQFMNN
     LEITFNLRDE EQAGVIPRRS FYPKSHTKES RYFRGVNSNG VSSRGNSMTG RQDSQYSDES
     ESGHGILEFS TEKAGQDVTP INLDFGEEKK RSSTLNSITG MLSQLKRSIP DLRLHKTHQP
     LIAQSTPPSS HRIRTIRRQS SVGTYQESAH QQQQPQPQVP ISSSTSYYTN SPSPPAPHVV
     EATQHSIETH SDLVVSKGLE NIHSKLEQLT RRVQQLEVSL AGDVKTILGL LQGGDRGHEM
     PEYENLDPSR IRYTFQRSVS EPKPISKSQQ HSQVLHRFAS FNKAFDFDKF QDSSWADTLV
     GKEKESKEDK SAPIAKLESL DELDLESPQG SPKKPKK
//
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