ID D2A6C5_TRICA Unreviewed; 1684 AA.
AC D2A6C5;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN Name=AUGUSTUS-3.0.2_15014 {ECO:0000313|EMBL:EFA04947.1};
GN Synonyms=Chc {ECO:0000313|EMBL:AHY84716.1};
GN ORFNames=TcasGA2_TC015014 {ECO:0000313|EMBL:EFA04947.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA04947.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA04947.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA04947.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA04947.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA04947.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
RN [3] {ECO:0000313|EMBL:EFA04947.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA04947.1};
RA Shelton J.M., Herndon N., Coleman C., Lu N., Brown S.J.;
RT "Tools and pipelines for BioNano data: molecule assembly pipeline and FASTA
RT super scaffolding tool.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AHY84716.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Georgia-1 {ECO:0000313|EMBL:AHY84716.1};
RX PubMed=25863352; DOI=10.1016/j.ibmb.2015.03.009;
RA Xiao D., Gao X., Xu J., Liang X., Li Q., Yao J., Zhu K.Y.;
RT "Clathrin-dependent endocytosis plays a predominant role in cellular uptake
RT of double-stranded RNA in the red flour beetle.";
RL Insect Biochem. Mol. Biol. 60:68-77(2015).
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
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DR EMBL; KJ476828; AHY84716.1; -; mRNA.
DR EMBL; KQ971347; EFA04947.1; -; Genomic_DNA.
DR RefSeq; NP_001280512.1; NM_001293583.1.
DR STRING; 7070.D2A6C5; -.
DR EnsemblMetazoa; TC015014_001; TC015014_001; TC015014.
DR GeneID; 656193; -.
DR KEGG; tca:656193; -.
DR eggNOG; KOG0985; Eukaryota.
DR HOGENOM; CLU_002136_0_0_1; -.
DR InParanoid; D2A6C5; -.
DR OMA; VMEISWR; -.
DR OrthoDB; 5474327at2759; -.
DR Proteomes; UP000007266; Linkage group 6.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IBA:GO_Central.
DR GO; GO:0045334; C:clathrin-coated endocytic vesicle; IBA:GO_Central.
DR GO; GO:0032051; F:clathrin light chain binding; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IBA:GO_Central.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 5.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 2: Evidence at transcript level;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 338..361
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
FT REPEAT 544..690
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 693..835
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 840..979
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 986..1131
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 1135..1276
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 1281..1427
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 1430..1573
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
SQ SEQUENCE 1684 AA; 192312 MW; 71F2F7ADECCCD72A CRC64;
MTQQLLPIKF QEHLQLTNVG INVANISFAT LTMESDKFIC VREKVGDTSQ VVIIDMGDTA
NPIRRPITAE SAIMNPASKV IALKGKAGVE AQKTLQIFNI EMKSKMKAHT MSEDVIFWKW
ISLNTLALVT ETSVYHWSME GDSTPVKMFD RHSSLNGCQI INYRTDPKQN WLLLVGISAQ
QSRVVGAMQL YSVERKCSQP IEGHAASFAT FKMEGNPEPS TLFCFAVRTV QGGKLHIIEV
GQSPAGNQPF PKKTVDVFFP PEAQNDFPVA MQVSAKYDVI YLITKYGYIH MYDIESAICI
YMNRISSETI FVTAPHESTG GIIGVNRRGQ VLSVSVDEDS IIRYVNQVLH NPDLALRIAT
RNNLAGAEEL FVNKFQMLFT NGQYAEAAKV AANAPKGILR TPATIQMFQQ VPTQPGQNSP
LLQYFGILLD QGQLNRYESL ELCKPVLLQG RKQLLEKWLK EDKLECSEEL GDLVKQADST
LALSVYLRAN VPAKVIQSFA ETGQFQKIVL YAKKVNYTPD YIYLLRSVMR TNPDQGAAFA
SMLVADEEPL ADINQIVDIF MEQNMVQQCT AFLLDALKHN RPTEGHLQTR LLEMNLMSAP
QVADAILGNN MFTHYDRAHI AQLCEKAGLL QRALEHYTDL YDIKRAVVHT HLLPMDWLVN
FFGTLSVEDS LECLKAMLTA NIRQNLQICV QIATKYHEQL TTKALIDLFE SFKSYEGLFY
FLGSIVNFSQ DPDVHFKYIQ AACKTGQIKE VERICRESNC YNPESVKNFL KEAKLTDQLP
LIIVCDRFDF VHDLVLYLYR NSLQKYIEIY VQKVNPSRLP VVVGGLLDVD CAEDIIKNLI
LVVRGQFSTD ELVEEVEKRN RLKLLLPWLE SRVHEGCVEP ATHNALAKIY IDSNNNAERF
LKENQWYDSR VVGRYCEKRD PHLACVAYER GQCDRELIAV CNENSLFKSE ARYLVRRRDP
ELWAEVLQES NPYRRQLIDQ VVQTALSETQ DPEDISVTVK AFMTADLPNE LIELLEKIVL
DSSVFSDHRN LQNLLILTAI KADATRVMDY INRLDNYDAP DIANIAINNH LYEEAFAIFK
KFDVNTSAIQ VLIEQVNNLD RAYEFAERCN EPAVWSQLAK AQLNQGLVKE AIDSYIKADD
PSAYMAVVET ASKNNSWEDL VRYLQMARKK SRESYIESEL IYSYAKTGRL ADLEEFISGP
NHADIQKIGD RCFDDKMYDA AKLLYNNVSN FARLAITLVH LKEFQGAVDS ARKANSTRTW
KEVCFACVDA EEFRLAQMCG MHIVVHADEL QDLINYYQDR GYFEELIGLL EAALGLERAH
MGMFTELAIL YSKYKPAKMR EHLELFWSRV NIPKVLRAAE QAHLWAELVF LYDKYEEYDN
AVLAMMAHPT EAWREGHFKD IITKVANIEL YYKAIQFYLD YKPLLLNDLL LVLAPRMDHT
RAVAFFTKTG HLQLVKSYLR SVQNLNNKAI NEALNSLLIE EEDFQGLRTS IDAFDNFDNI
GLAQKLEKHE LTEFRRIAAY LYKGNNRWKQ SVELCKKDRL FRDAMEYTAE SKNQELAEEL
LAWFLERKAY DCFAACLYQC YDLLRPDVIL ELAWRHKIMD LAMPYLIQVT RELTTKVEKL
EQSDAQRQSE AAEETHKPMM INEPQLMLTA GPGMGIPPQA YVPPQAYAQP GYAPQMPYGA
YPGM
//