ID   D2BG54_DEHMV            Unreviewed;       677 AA.
AC   D2BG54;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   SubName: Full=Pyridine nucleotide-disulphide oxidoreductase protein {ECO:0000313|EMBL:ACZ61304.1};
GN   OrderedLocusNames=DhcVS_131 {ECO:0000313|EMBL:ACZ61304.1};
OS   Dehalococcoides mccartyi (strain VS).
OC   Bacteria; Chloroflexota; Dehalococcoidia; Dehalococcoidales;
OC   Dehalococcoidaceae; Dehalococcoides.
OX   NCBI_TaxID=311424 {ECO:0000313|EMBL:ACZ61304.1, ECO:0000313|Proteomes:UP000002506};
RN   [1] {ECO:0000313|EMBL:ACZ61304.1, ECO:0000313|Proteomes:UP000002506}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VS {ECO:0000313|EMBL:ACZ61304.1,
RC   ECO:0000313|Proteomes:UP000002506};
RX   PubMed=19893622; DOI=10.1371/journal.pgen.1000714;
RA   McMurdie P.J., Behrens S.F., Muller J.A., Goke J., Ritalahti K.M.,
RA   Wagner R., Goltsman E., Lapidus A., Holmes S., Loffler F.E., Spormann A.M.;
RT   "Localized plasticity in the streamlined genomes of vinyl chloride
RT   respiring Dehalococcoides.";
RL   PLoS Genet. 5:E1000714-E1000714(2009).
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR   EMBL; CP001827; ACZ61304.1; -; Genomic_DNA.
DR   AlphaFoldDB; D2BG54; -.
DR   KEGG; dev:DhcVS_131; -.
DR   eggNOG; COG0493; Bacteria.
DR   eggNOG; COG1143; Bacteria.
DR   eggNOG; COG1145; Bacteria.
DR   HOGENOM; CLU_000422_3_4_0; -.
DR   Proteomes; UP000002506; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.30.70.3270; -; 1.
DR   Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR028261; DPD_II.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   PANTHER; PTHR43073; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR   PANTHER; PTHR43073:SF2; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF00037; Fer4; 2.
DR   Pfam; PF14691; Fer4_20; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR   SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR   SUPFAM; SSF51971; Nucleotide-binding domain; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002506};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        654..676
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          109..138
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          601..630
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
SQ   SEQUENCE   677 AA;  74098 MW;  C7F14C5C5B46FFEC CRC64;
     MILISYFCFV NPLFETLLSL HTDTGYRVGQ RTEGVVELTC LSRQRSSRID NVLYVASIIS
     GTRSFKYRRK YFKKETYMAK TKAPVEKLES AEEIQKDGKV VSTKRTKGSE FFWTQSRCTG
     CNRCASVCPV DAIKLDRDKT PTKRVGTSPC TRACPAGLDI PRYVRFVADG NASAATAVMR
     EKIPFPSVCG YVCFHPCELE CQRQKFDEPI AIRALKRYAA ENDDGSWKNN LKIAPPTGKK
     VAIIGSGPAG LTSAYFLTLL GHEATIFESM EYAGGKMFYS IPEHQLPKDI LNKEIKTITD
     LGVTIHTSCQ VQSVQTLFKQ GYNSVLLSTG VLGLDEGLLL PCDETVESNL IKGSDFLKSI
     KSTTKESLGD KVVVIGGGSE AYNSAFAAKN LGVSEVHLVC SRHTGSKEAS PEEVDRAIDA
     GVTVHPSLDF VKLVKSDDKI EGVELFRIRS YGYDKDNRLH YEIINDTRCL IPADTVITTV
     APDEKPGADY LTVVQPGVFA AGDGISGARS VIEAMAAGRS VAGLIDKYLG GEGNLDETLA
     PPEKDIKPLS EPKGQNRSQI ELNLVKQAGG DKVEIEKTLS PEAAKKEARR CLRCDIVHQV
     HDYSLDTSSC TYCGRCVNAC YWDAITSGYG YEAAAKKRQA EIAALEEKHS VYNYAIRILP
     IAIGLMILAA AVAKLFK
//