ID   D2BJ64_DEHMV            Unreviewed;       497 AA.
AC   D2BJ64;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Reductive dehalogenase {ECO:0000313|EMBL:ACZ62364.1};
GN   Name=rdhA {ECO:0000313|EMBL:ACZ62364.1};
GN   OrderedLocusNames=DhcVS_1263 {ECO:0000313|EMBL:ACZ62364.1};
OS   Dehalococcoides mccartyi (strain VS).
OC   Bacteria; Chloroflexota; Dehalococcoidia; Dehalococcoidales;
OC   Dehalococcoidaceae; Dehalococcoides.
OX   NCBI_TaxID=311424 {ECO:0000313|EMBL:ACZ62364.1, ECO:0000313|Proteomes:UP000002506};
RN   [1] {ECO:0000313|EMBL:ACZ62364.1, ECO:0000313|Proteomes:UP000002506}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VS {ECO:0000313|EMBL:ACZ62364.1,
RC   ECO:0000313|Proteomes:UP000002506};
RX   PubMed=19893622; DOI=10.1371/journal.pgen.1000714;
RA   McMurdie P.J., Behrens S.F., Muller J.A., Goke J., Ritalahti K.M.,
RA   Wagner R., Goltsman E., Lapidus A., Holmes S., Loffler F.E., Spormann A.M.;
RT   "Localized plasticity in the streamlined genomes of vinyl chloride
RT   respiring Dehalococcoides.";
RL   PLoS Genet. 5:E1000714-E1000714(2009).
CC   -!- COFACTOR:
CC       Name=corrinoid; Xref=ChEBI:CHEBI:33913;
CC         Evidence={ECO:0000256|ARBA:ARBA00029374};
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DR   EMBL; CP001827; ACZ62364.1; -; Genomic_DNA.
DR   RefSeq; WP_012882508.1; NC_013552.1.
DR   AlphaFoldDB; D2BJ64; -.
DR   KEGG; dev:DhcVS_1263; -.
DR   eggNOG; COG1600; Bacteria.
DR   HOGENOM; CLU_036586_0_1_0; -.
DR   OrthoDB; 9807879at2; -.
DR   Proteomes; UP000002506; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.20; -; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR012832; RDH.
DR   InterPro; IPR028894; RDH_dom.
DR   InterPro; IPR006311; TAT_signal.
DR   InterPro; IPR019546; TAT_signal_bac_arc.
DR   NCBIfam; TIGR02486; RDH; 1.
DR   NCBIfam; TIGR01409; TAT_signal_seq; 1.
DR   PANTHER; PTHR42827:SF1; IRON-SULFUR CLUSTER BINDING PROTEIN; 1.
DR   PANTHER; PTHR42827; IRON-SULFUR CLUSTER-BINDING PROTEIN-RELATED; 1.
DR   Pfam; PF13486; Dehalogenase; 1.
DR   Pfam; PF13484; Fer4_16; 1.
DR   Pfam; PF10518; TAT_signal; 1.
DR   SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
DR   PROSITE; PS51318; TAT; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002506};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          350..382
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
SQ   SEQUENCE   497 AA;  54892 MW;  3B835656D3C3AF3F CRC64;
     MPNFHSALSR RDFMKGLGVV GAGLGTAAAA APAFRDLDDV ISSPNAEWKR PWWVKYRELD
     NPTTEIDWSL MNRWDGRQTG QAPGIQAKYL GVDEIKKRYA NVLTNKVNAI TSETPGQTLK
     DYALSSGAGF FMNLPYVTTF MGPQKVATPQ SMNVPAWQGT PEENSRMLRS AVIFYGGGQV
     GFGVIDQKIK DKLVFTNHKG AANSIGFVEN FPPPPALGKA YVFEDVDVGY EGATTFVLPA
     NKQLYEFCFT VPMSKDMFRT ANESQIMYAA NLSRYRLFGN IQNSIQEFIR SLGYTCYGYA
     SPFSGIMPAI ASAQLTGITE GNRNNGFCTS PEYGPVLGVF SLVTDMPLEP TNPIDAGIWR
     FCQTCTKCAD ACPVNAIPKD HEPTWDLPNI YGKADIVHSP GRKQYWTNAV DCWLFLTEYN
     GCGACMATCT FNTNTAPIHE LVRATLATTP TLNTFLWQAD KFFGYGLNED KEEWWDLSLP
     VYGFDSAATS SHGGYDK
//