UniProt: D2CFW5

Database: UniProt
Entry: D2CFW5_TRICA

LinkDB:  D2CFW5_TRICA 
Original site:  D2CFW5_TRICA

All links

Ontology (9)   
   GO (9)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (24)   
   InterPro (14)   
   Pfam (8)   
   PROSITE (1)   
   SMART (1)   
Literature (2)   
   PubMed (2)   
All databases (40)   

Download RDF

ID   D2CFW5_TRICA            Unreviewed;      2364 AA.
AC   D2CFW5;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   24-JAN-2024, entry version 66.
DE   SubName: Full=Pre-mRNA-processing-splicing factor 8-like Protein {ECO:0000313|EMBL:EFA13035.1};
GN   Name=AUGUSTUS-3.0.2_10565 {ECO:0000313|EMBL:EFA13035.1};
GN   ORFNames=TcasGA2_TC010565 {ECO:0000313|EMBL:EFA13035.1};
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA13035.1, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:EFA13035.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA13035.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=18362917; DOI=10.1038/nature06784;
RG   Tribolium Genome Sequencing Consortium;
RA   Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA   Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA   Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA   Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA   Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA   Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA   Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA   Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA   Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA   Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA   Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA   Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA   Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA   Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA   Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA   Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA   Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA   Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA   Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA   Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA   Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA   Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA   Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA   Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA   Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA   Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA   Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA   Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA   Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA   Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA   Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA   Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA   Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA   Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA   Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA   Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA   Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA   Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA   Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA   Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA   Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT   "The genome of the model beetle and pest Tribolium castaneum.";
RL   Nature 452:949-955(2008).
RN   [2] {ECO:0000313|EMBL:EFA13035.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA13035.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=19820115; DOI=10.1093/nar/gkp807;
RA   Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA   Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT   "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT   for Tribolium castaneum.";
RL   Nucleic Acids Res. 38:D437-D442(2010).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KQ972625; EFA13035.1; -; Genomic_DNA.
DR   RefSeq; XP_015840170.1; XM_015984684.1.
DR   RefSeq; XP_966931.1; XM_961838.3.
DR   STRING; 7070.D2CFW5; -.
DR   EnsemblMetazoa; TC010565_001; TC010565_001; TC010565.
DR   GeneID; 655310; -.
DR   KEGG; tca:655310; -.
DR   eggNOG; KOG1795; Eukaryota.
DR   HOGENOM; CLU_000380_3_0_1; -.
DR   InParanoid; D2CFW5; -.
DR   OMA; ANKWNTS; -.
DR   OrthoDB; 246127at2759; -.
DR   PhylomeDB; D2CFW5; -.
DR   Proteomes; UP000007266; Unassembled WGS sequence.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0097157; F:pre-mRNA intronic binding; IBA:GO_Central.
DR   GO; GO:0030619; F:U1 snRNA binding; IBA:GO_Central.
DR   GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR   GO; GO:0030623; F:U5 snRNA binding; IBA:GO_Central.
DR   GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IBA:GO_Central.
DR   CDD; cd08056; MPN_PRP8; 1.
DR   CDD; cd13838; RNase_H_like_Prp8_IV; 1.
DR   Gene3D; 1.20.80.40; -; 1.
DR   Gene3D; 3.30.420.230; -; 1.
DR   Gene3D; 3.90.1570.40; -; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR012591; PRO8NT.
DR   InterPro; IPR012592; PROCN.
DR   InterPro; IPR012984; PROCT.
DR   InterPro; IPR027652; PRP8.
DR   InterPro; IPR021983; PRP8_domainIV.
DR   InterPro; IPR043173; Prp8_domainIV_fingers.
DR   InterPro; IPR043172; Prp8_domainIV_palm.
DR   InterPro; IPR019581; Prp8_U5-snRNA-bd.
DR   InterPro; IPR042516; Prp8_U5-snRNA-bd_sf.
DR   InterPro; IPR019580; Prp8_U6-snRNA-bd.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR019582; RRM_spliceosomal_PrP8.
DR   PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR   PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF08082; PRO8NT; 1.
DR   Pfam; PF08083; PROCN; 1.
DR   Pfam; PF08084; PROCT; 1.
DR   Pfam; PF12134; PRP8_domainIV; 1.
DR   Pfam; PF10598; RRM_4; 1.
DR   Pfam; PF10597; U5_2-snRNA_bdg; 1.
DR   Pfam; PF10596; U6-snRNA_bdg; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR   PROSITE; PS50249; MPN; 1.
PE   4: Predicted;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT   DOMAIN          2132..2263
FT                   /note="MPN"
FT                   /evidence="ECO:0000259|PROSITE:PS50249"
SQ   SEQUENCE   2364 AA;  276207 MW;  D6DA1BCDA6D9D356 CRC64;
     MSLPPYLLGP NPWATMMAQQ HLAAAHAQAQ AAAAQAHAHA LQQQIPPPHP KSDVMTEEKL
     QEKAQKWHQL QSKRFADKRK LGFVDAQKED MPPEHIRKII RDHGDMSSRK YRHDKRVYLG
     ALKYMPHAVM KLLENMPMPW EQIRDVKVLY HITGAITFVN EIPWVIEPIY IAQWGTMWIM
     MRREKRDRRH FKRMRFPPFD DEEPPLDYAD NVLDVEPLEA IQIELDAEED AEVAKWFYDH
     KPLVGMKYVN GPTYRKWNLT LPMMATLYRL ANQLLTDLVD NNYFYLFDTK SFFTAKALNM
     AIPGGPKFEP LIKDMNPADE DWNEFNDINK IIIRQPIRTE YRIAFPYLYN NMPHFVHLSW
     YHAPNVVYIK TEDPDLPAFY FDPLINPISH RHAVKSLEPL PEDDEEYILP EHVQPFLQET
     PLYTDNTANG IALLWAPRPF NLRSGRCRRA IDVPLVKTWY MEHCPPGQPV KVRVSYQKLL
     KYYVLNALKH RPPKAQKKRY LFRSFKSTKF FQTTTLDWVE AGLQVCRQGY NMLNLLIHRK
     NLNYLHLDYN FNLKPVKTLT TKERKKSRFG NAFHLCREIL RLTKLIIDSH VQYRLNNVDA
     FQLADGLQYI FAHVGQLTGM YRYKYKLMRQ IRMCKDLKHL VYYRFNTGPV GKGPGCGFWA
     PGWRVWLFFM RGITPLLERW LGNLLSRQFE GRHSKGVAKT VTKQRVESHF DLELRASVMH
     DIVDMMPEGI KQNKARTILQ HLSEAWRCWK ANIPWKVPGL PIPIENMILR YVKMKADWWT
     NTAHYNRERI RRGATVDKTV CKKNLGRLTR LYLKAEQERQ HNYLKDGPYI SPEEAVAIYT
     TTVHWLESRR FAPIPFPPLS YKHDTKLLIL ALERLKEAYS VKSRLNQSQR EELGLIEQAY
     DNPHEALSRI KRHLLTQRAF KEVGIEFMDL YSHLIPVYDV EPLEKITDAY LDQYLWYEAD
     KRRLFPPWIK PADTEPPPLL VYKWCQGINN LQDVWDVSEG ECNVLLESKF EKLYEKIDLT
     LLNRLLRLIV DHNIADYMTA KNNVVINYKD MNHTNSYGII RGLQFASFIT QYYGLVLDLL
     VLGLQRASEM AGPPQMPNDF LTFQDVSTET CHPIRLYCRY VDKIHMFFRF TAEEARELIQ
     RYLTEHPDPN NENIVGYNNK KCWPRDARMR LMKHDVNLGR AVFWDIKNRL PRSVTTIQWE
     NSFVSVYSKD NPNLLFNMCG FECRILPKCR TQHEEFTHRD GVWNLQHEGS KERTAQCFLR
     VDDESMSRFH NRVRQILMAS GSTTFTKIVN KWNTALIGLM TYFREAVVNT QELLDLLVKC
     ENKIQTRIKI GLNSKMPSRF PPVVFYTPKE LGGLGMLSMG HVLIPQSDLR WSKQTDVGIT
     HFRSGMSHDE DQLIPNLYRY IQPWESEFID SQRVWAEYSL KRQEANAQNR RLTLEDLEDS
     WDRGIPRINT LFQKDRHTLA YDKGWRIRTE FKQYQVLKQN PFWWTHQRHD GKLWNLNNYR
     TDMIQALGGV EGILEHTLFK GTYFPTWEGL FWEKASGFEE SMKYKKLTNA QRSGLNQIPN
     RRFTLWWSPT INRANVYVGF QVQLDLTGIF MHGKIPTLKI SLIQIFRAHL WQKVHESIVM
     DLCQVFDQEL DALEIETVQK ETIHPRKSYK MNSSCADILL FSAYKWNVSR PSLLADTKDT
     MDNTTTQKYW IDVQLRWGDY DSHDIERYAR AKFLDYTTDN MSIYPSPTGV LIAIDLAYNL
     HSAYGNWFPG CKPLIQQAMA KIMKANPALY VLRERIRKAL QLYSSEPTEP YLSSQNYGEL
     FSNQIIWFVD DTNVYRVTIH KTFEGNLTTK PINGAIFIFN PRTGQLFLKI IHTSVWAGQK
     RLGQLAKWKT AEEVAALIRS LPVEEQPKQI IVTRKGMLDP LEVHLLDFPN IVIKGSELQL
     PFQACLKIEK FGDLILKATE PQMVLFNLYD DWLKTISSYT AFSRLILILR ALHVNTERTK
     VILKPDKTTI TEPHHIWPTL SDDEWIKVEV QLKDLILADY GKKNNVNVAS LTQSEIRDII
     LGMEISAPSA QRQQIAEIEK QTKEQSQLTA TTTRTVNKHG DEIITSTTSN YETQTFSSKT
     EWRVRAISAT NLHLRTNHIY VSSDDIKETG YTYILPKNVL KKFVTISDLR AQICAFLYGV
     SPPDNPQVKE LRCLVLPPQW GTHQTVHIPN TPPNHPFLKD MEPLGWIHTQ PNELPQLSPQ
     DITTHAKLMA DNPAWDGEKT VIITCSFTPG SCSLTAYKLT PSGYEWGRAN TDKGNNPKGY
     LPSHYEKVQM LLSDRFLGFF MVPAQGSWNY NFMGVRHDPS MKYELQLANP KEFYHEIHRP
     AHFLNFSSLE DGDGAGADRE DMFA
//

DBGET integrated database retrieval system