ID D2DWL5_9SALA Unreviewed; 915 AA.
AC D2DWL5;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Interleukin-6 signal transducer {ECO:0000313|EMBL:ACW83267.1};
OS Plethodon shermani (red-legged salamander).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Caudata; Salamandroidea; Plethodontidae; Plethodontinae;
OC Plethodon.
OX NCBI_TaxID=263671 {ECO:0000313|EMBL:ACW83267.1};
RN [1] {ECO:0000313|EMBL:ACW83267.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21670553; DOI=10.1266/ggs.86.131;
RA Kiemnec-Tyburczy K.M., Watts R.A., Arnold S.J.;
RT "Characterization of two putative cytokine receptors, gp130 and ciliary
RT neurotrophic factor receptor, from terrestrial salamanders.";
RL Genes Genet. Syst. 86:131-137(2011).
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FJ824846; ACW83267.1; -; mRNA.
DR AlphaFoldDB; D2DWL5; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF109; LEPTIN RECEPTOR; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..915
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003030036"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 229..330
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 335..428
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 524..619
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 727..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..900
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 915 AA; 101877 MW; 1B5597EF1F503DB0 CRC64;
MTYAIFVPLV ICFLKGAELQ MPAATVPFQR VKSCAHIIPE SPFVKLGSQF TAYCILNETC
ISHYDQDASN IIWKVKQSKI PEEQYTTINR TVSSVTLNVT SALDSFLTCN VLVYGQLEQS
LYGISLTVGH PPDKPEDFAC IAYPVNDGIK NLTCTWNPGQ PTLLSTTYTL RTRWSKGGDH
VCVTTSANNT CTINDVNFYI NTEIWVEAEN ALGKVESERI HDDPVNLAQF RPPRISNLTC
YPDLPNSIQI EWENPSNLVP LKYIIRYRSS NTAVWDEVPP EDTASRKTSF QLQGLQPYTE
YTISLRCMKE DGAGYWSDWS AEKSVITTEA KPIKGPDLWQ GIISNTEGKT HVRLKWKELD
RTEANGKVLG YRIKVTSRIS RISETFNTTD TILDVILANH LYDVTLTAYN SVAESPKSVL
SIKAGNSGGL PPVKNVRVFP EDKKLRVEWN APNASVKGYV IEWYLCSSAL CSPCQWQREP
KTSRGAYLRG VLEERKLYLI KVYPLYSTGV GEAQSIKAYL EQGPPSKAPD IRTKNMGKTE
VTLVWDPIPL EDRNGFITKY TILYRQSNGN DSFVDVLPNK TEYTLSSLSG DTQYRVCMRA
STEKGDTDGQ ALTFTTSKFA KGEIEAIVVP SCIGVLIVTL LGITYGFSKR DLIKKHIWPN
IPDPSKSTIV KMSPHTPTRH NFSSKNQAYP EESFTDVSVV EITTDDKKSF SEQDLKPLDL
LRKEMNTSEG HSSGIGGSSC MSSPRQSVSD SEDSESTQTT SSTVQYSTVV LSGYRDQKPT
PPVHAFSRSE STQPLLESEE RPEDQQPVDV TTYKLQSNQY FKQNCGDERN PEGSQYEQSK
NGLQFTNQED GQLPFSGTPA PASGVFSMED ECSGNVLAED QVSASSETLE SESTTCGEPK
SYLPQVVRKG GYMPQ
//