ID D2DY29_9FLAV Unreviewed; 223 AA.
AC D2DY29;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Polyprotein {ECO:0000313|EMBL:ACZ69397.1};
DE Flags: Fragment;
OS Yellow fever virus.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Orthoflavivirus; Orthoflavivirus flavi.
OX NCBI_TaxID=11089 {ECO:0000313|EMBL:ACZ69397.1};
RN [1] {ECO:0000313|EMBL:ACZ69397.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SPAn289568 {ECO:0000313|EMBL:ACZ69397.1};
RA Santos C.L.S., Maeda A.Y.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACZ69397.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SPAn289568 {ECO:0000313|EMBL:ACZ69397.1};
RX PubMed=19950229; DOI=10.1002/jmv.21606;
RA de Souza R.P., Foster P.G., Sallum M.A., Coimbra T.L., Maeda A.Y.,
RA Silveira V.R., Moreno E.S., da Silva F.G., Rocco I.M., Ferreira I.B.,
RA Suzuki A., Oshiro F.M., Petrella S.M., Pereira L.E., Katz G., Tengan C.H.,
RA Siciliano M.M., Dos Santos C.L.;
RT "Detection of a new yellow fever virus lineage within the South American
RT genotype I in Brazil.";
RL J. Med. Virol. 82:175-185(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004385}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004385}.
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DR EMBL; FJ875520; ACZ69397.1; -; Genomic_RNA.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR CDD; cd17038; Flavi_M; 1.
DR Gene3D; 1.10.8.970; Flavivirus envelope glycoprotein M-like; 1.
DR Gene3D; 2.60.260.50; Flavivirus polyprotein propeptide domain; 1.
DR Gene3D; 2.60.98.10; Tick-borne Encephalitis virus Glycoprotein, domain 1; 1.
DR InterPro; IPR000069; Env_glycoprot_M_flavivir.
DR InterPro; IPR038302; Env_glycoprot_M_sf_flavivir.
DR InterPro; IPR011998; Flavi_Glycoprot_E_cen/dimer.
DR InterPro; IPR002535; Flavi_propep.
DR InterPro; IPR038688; Flavi_propep_sf.
DR InterPro; IPR036253; Glycoprot_cen/dimer_sf.
DR InterPro; IPR038055; Glycoprot_E_dimer_dom.
DR Pfam; PF00869; Flavi_glycoprot; 1.
DR Pfam; PF01004; Flavi_M; 1.
DR Pfam; PF01570; Flavi_propep; 1.
DR SUPFAM; SSF56983; Viral glycoprotein, central and dimerisation domains; 1.
PE 4: Predicted;
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022804};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Virion {ECO:0000256|ARBA:ARBA00022804};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 71..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..35
FT /note="Flavivirus polyprotein propeptide"
FT /evidence="ECO:0000259|Pfam:PF01570"
FT DOMAIN 38..111
FT /note="Envelope glycoprotein M flavivirus"
FT /evidence="ECO:0000259|Pfam:PF01004"
FT DOMAIN 113..223
FT /note="Envelope glycoprotein E central and dimerisation"
FT /evidence="ECO:0000259|Pfam:PF00869"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACZ69397.1"
FT NON_TER 223
FT /evidence="ECO:0000313|EMBL:ACZ69397.1"
SQ SEQUENCE 223 AA; 24546 MW; 298F625463629DEC CRC64;
PREEPDDIDC WCYGVENVRV AYGKCDSAGR SRRSRRAIDL PTHENHGLKT RQEKWMTGRM
GERQLQKIER WLVRNPFFAA TALAIAYLVG SNMTQRVVIA LLVLAVGPAY SAHCIGITDR
DFIEGVHGGT WVSATLEQDK CVTVMAPDKP SLDISLETVA IDGPAEARKV CYSAVLTNVK
INDKCPSTGE AHLEEENEGD NACKRTYSDR GWGNGCGLFG KGS
//
