ID   D2EAV9_LEIME            Unreviewed;       459 AA.
AC   D2EAV9;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Heat shock protein 70 {ECO:0000313|EMBL:CAZ04905.1};
DE   Flags: Fragment;
GN   Name=hsp70 {ECO:0000313|EMBL:CAZ04905.1};
OS   Leishmania mexicana.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5665 {ECO:0000313|EMBL:CAZ04905.1};
RN   [1] {ECO:0000313|EMBL:CAZ04905.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MHOM/PE/02/LH2312 {ECO:0000313|EMBL:CAZ04905.1};
RX   PubMed=19913110; DOI=10.1016/j.meegid.2009.11.007;
RA   Fraga J., Montalvo A.M., De Doncker S., Dujardin J.C., Van der Auwera G.;
RT   "Phylogeny of Leishmania species based on the heat-shock protein 70 gene.";
RL   Infect. Genet. Evol. 10:238-245(2010).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000256|ARBA:ARBA00007381}.
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DR   EMBL; FN395038; CAZ04905.1; -; Genomic_DNA.
DR   AlphaFoldDB; D2EAV9; -.
DR   SMR; D2EAV9; -.
DR   VEuPathDB; TriTrypDB:LmxM.28.2770; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375:SF395; HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED; 1.
DR   PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR   SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Stress response {ECO:0000313|EMBL:CAZ04905.1}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAZ04905.1"
FT   NON_TER         459
FT                   /evidence="ECO:0000313|EMBL:CAZ04905.1"
SQ   SEQUENCE   459 AA;  50375 MW;  96FAEF9DF01561D8 CRC64;
     DSQRQATKDA GTISGLEVLR IINEPTAAAI AYGLDKGDDG KERNVLIFDL GGGTFDVTLL
     TIDGGIFEVK ATNGDTHLGG EDFDNRLVTF FTEEFKRKNK GKNLASSHRS LRRLRTACER
     AKRTLSSATQ ATIEIDALFD NVDFQATITR ARFEELCGDL FRSTIQPVER VLQDAKMDKR
     SVHDVVLVGG STRIPKVQSL VSDFFGGKEL NKSINPDEAV AYGAAVQAFI LTGGKSKQTE
     GLLLLDVTPL TLGIETAGGV MTALIKRNTT IPTKKSQIFS TYADNQPGVH IQVFEGERAM
     TKDCHLLGTF DLSGIPPAPR GVPQIEVTFD LDANGILNVS AEEKGTGKRN QITITNDKGR
     LSKDEIERMV NDAMKYEADD KAQRDRVEAK NGLENYAYSM KNTLGDSNVS GKLDDTDKST
     LNKEIEAALE WLSSNQEATK EEYEHKQKEL ENVCNPIMT
//